6ANL

Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors

Summary for 6ANL

Entry DOI	10.2210/pdb6anl/pdb
Related	5WJJ
Descriptor	Mitogen-activated protein kinase 14, TAK-715 (3 entities in total)
Functional Keywords	transferase-transferase inhibitor complex, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q16539
Total number of polymer chains	1
Total formula weight	42114.03
Authors	Snell, G.P.,Okada, K.,Bragstad, K.,Sang, B.-C. (deposition date: 2017-08-14, release date: 2018-01-17, Last modification date: 2024-03-13)
Primary citation	Kaieda, A.,Takahashi, M.,Takai, T.,Goto, M.,Miyazaki, T.,Hori, Y.,Unno, S.,Kawamoto, T.,Tanaka, T.,Itono, S.,Takagi, T.,Hamada, T.,Shirasaki, M.,Okada, K.,Snell, G.,Bragstad, K.,Sang, B.C.,Uchikawa, O.,Miwatashi, S. Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors. Bioorg. Med. Chem., 26:647-660, 2018 Cited by PubMed: 29291937 DOI: 10.1016/j.bmc.2017.12.031 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation