5WJJ
Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors
Summary for 5WJJ
Entry DOI | 10.2210/pdb5wjj/pdb |
Descriptor | Mitogen-activated protein kinase 14, N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methyl-1-oxo-1lambda~5~-pyridine-4-carboxamide (3 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 42168.98 |
Authors | Snell, G.P.,Okada, K.,Bragstad, K.,Sang, B.-C. (deposition date: 2017-07-23, release date: 2018-01-17, Last modification date: 2024-03-13) |
Primary citation | Kaieda, A.,Takahashi, M.,Takai, T.,Goto, M.,Miyazaki, T.,Hori, Y.,Unno, S.,Kawamoto, T.,Tanaka, T.,Itono, S.,Takagi, T.,Hamada, T.,Shirasaki, M.,Okada, K.,Snell, G.,Bragstad, K.,Sang, B.C.,Uchikawa, O.,Miwatashi, S. Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors. Bioorg. Med. Chem., 26:647-660, 2018 Cited by PubMed: 29291937DOI: 10.1016/j.bmc.2017.12.031 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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