6SJC

Structure of T. thermophilus AspRS in Complex with 5'-O-(N-(L-aspartyl)-sulfamoyl)adenosine

Summary for 6SJC

Entry DOI	10.2210/pdb6sjc/pdb
Related	6HDZ 6HE1 6HE3 6HHV 6HHW 6HHX 6HHY 6HHZ 6HI0 6RLT 6RLU 6RLV
Descriptor	Aspartate--tRNA(Asp) ligase, 5'-O-(L-alpha-aspartylsulfamoyl)adenosine (3 entities in total)
Functional Keywords	protein-inhibitor complex, trna aminoacylation, ligase
Biological source	Thermus thermophilus
Total number of polymer chains	2
Total formula weight	133286.47
Authors	De Graef, S.,Pang, L.,Strelkov, S.V.,Weeks, S.D. (deposition date: 2019-08-13, release date: 2020-01-08, Last modification date: 2024-01-24)
Primary citation	Pang, L.,Nautiyal, M.,De Graef, S.,Gadakh, B.,Zorzini, V.,Economou, A.,Strelkov, S.V.,Van Aerschot, A.,Weeks, S.D. Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases. Acs Chem.Biol., 15:407-415, 2020 Cited by PubMed: 31869198 DOI: 10.1021/acschembio.9b00887 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.23 Å)

Structure validation