PDB: 5653 件ウェブページステータス検索Chemie searchBIRD

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1D7A	CRYSTAL STRUCTURE OF E. COLI PURE-MONONUCLEOTIDE COMPLEX. 分子名称: 5-AMINOIMIDAZOLE RIBONUCLEOTIDE, PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE 著者 Mathews, I.I, Kappock, T.J, Stubbe, J, Ealick, S.E. 登録日 1999-10-16 公開日 1999-12-03 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway. Structure Fold.Des., 7, 1999
4FFX	Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency Associated Mutation 分子名称: Adenylosuccinate lyase 著者 Deaton, M.K, Ray, S.P, Capodagli, G.C, Calkins, L.A.F, Sawle, L, Ghosh, K, Patterson, D, Pegan, S.D. 登録日 2012-06-01 公開日 2012-08-01 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency-Associated Mutation. Biochemistry, 51, 2012
4FLC	Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency Associated Mutation 分子名称: Adenylosuccinate lyase 著者 Deaton, M.K, Ray, S.P, Capodagli, G.C, Calkins, L.A.F, Sawle, L, Ghosh, K, Patterson, D, Pegan, S.D. 登録日 2012-06-14 公開日 2012-08-01 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency-Associated Mutation. Biochemistry, 51, 2012
6UY4	Crystal structure of dihydroorotate dehydrogenase from Schistosoma mansoni 分子名称: 2-[(4-fluorophenyl)amino]-3-hydroxynaphthalene-1,4-dione, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... 著者 Mori, R.M, Zapata, L.C.C, Nonato, M.C. 登録日 2019-11-11 公開日 2020-05-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.796 Å) 主引用文献 Structural basis for the function and inhibition of dihydroorotate dehydrogenase from Schistosoma mansoni. Febs J., 288, 2021
7LVP	Cryptococcus neoformans AIR synthetase 分子名称: 1,2-ETHANEDIOL, AIR synthase, GLYCINE, ... 著者 Chua, S.M.H, Luo, Z, Lim, B.Y.J, Kobe, B, Fraser, J.A. 登録日 2021-02-26 公開日 2021-08-25 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets. J.Biol.Chem., 297, 2021
7LVO	Cryptococcus neoformans GAR synthetase 分子名称: 1,2-ETHANEDIOL, phosphoribosyl-glycinamide (GAR) synthetase 著者 Chua, S.M.H, Luo, Z, Lim, B.Y.J, Kobe, B, Fraser, J.A. 登録日 2021-02-26 公開日 2021-08-25 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets. J.Biol.Chem., 297, 2021
4X8I	de novo crystal structure of the Pyrococcus Furiosus TET3 aminopeptidase 分子名称: 10-((2R)-2-HYDROXYPROPYL)-1,4,7,10-TETRAAZACYCLODODECANE 1,4,7-TRIACETIC ACID, CHLORIDE ION, COBALT (II) ION, ... 著者 Colombo, M. 登録日 2014-12-10 公開日 2016-02-10 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Tuned by metals: the TET peptidase activity is controlled by 3 metal binding sites. Sci Rep, 6, 2016
6OFB	Crystal structure of human glutamine-dependent NAD+ synthetase complexed with NaAD+, AMP, pyrophosphate, and Mg2+ 分子名称: ADENOSINE MONOPHOSPHATE, CHLORIDE ION, Glutamine-dependent NAD(+) synthetase, ... 著者 Chuenchor, W, Doukov, T.I, Gerratana, B. 登録日 2019-03-28 公開日 2020-01-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 Different ways to transport ammonia in human and Mycobacterium tuberculosis NAD+synthetases. Nat Commun, 11, 2020
5VGM	Crystal structure of dihydroorotase pyrC from Vibrio cholerae in complex with zinc at 1.95 A resolution. 分子名称: ACETATE ION, CHLORIDE ION, Dihydroorotase, ... 著者 Lipowska, J, Shabalin, I.G, Miks, C.D, Winsor, J, Cooper, D.R, Shuvalova, L, Kwon, K, Lewinski, K, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2017-04-11 公開日 2017-04-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Pyrimidine biosynthesis in pathogens - Structures and analysis of dihydroorotases from Yersinia pestis and Vibrio cholerae. Int.J.Biol.Macromol., 136, 2019
8OFW	Crystal structure of the full-length dihydroorotate dehydrogenase from Mycobacterium tuberculosis 分子名称: Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE 著者 Alberti, M, Ferraris, D.M, Miggiano, R. 登録日 2023-03-17 公開日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor. Febs Lett., 597, 2023
8U0Z	CRYSTAL STRUCTURE OF THE OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE DOMAIN OF Coffea arabica UMP SYNTHASE 分子名称: 1,2-ETHANEDIOL, ANY 5'-MONOPHOSPHATE NUCLEOTIDE, DI(HYDROXYETHYL)ETHER, ... 著者 Hinojosa-Cruz, A, Diaz-Vilchis, A, Gonzalez-Segura, L. 登録日 2023-08-29 公開日 2024-01-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.399 Å) 主引用文献 Structural and functional properties of uridine 5'-monophosphate synthase from Coffea arabica. Int.J.Biol.Macromol., 259, 2024
1F76	ESCHERICHIA COLI DIHYDROOROTATE DEHYDROGENASE 分子名称: Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, FORMIC ACID, ... 著者 Norager, S, Jensen, K.F, Bjornberg, O, Larsen, S. 登録日 2000-06-26 公開日 2002-10-16 最終更新日 2014-03-12 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 E. coli Dihydroorotate Dehydrogenase Reveals Structural and Functional Distinction between different classes of dihydroorotate dehydrogenases Structure, 10, 2002
6J3B	Crystal structure of human DHODH in complex with inhibitor 1289 分子名称: (6R)-1-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]-6-propan-2-yl-6,7-dihydro-5H-benzotriazol-4-one, ACETATE ION, CHLORIDE ION, ... 著者 Yu, Y, Chen, Q. 登録日 2019-01-04 公開日 2019-08-21 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode. Febs Open Bio, 9, 2019
8ABX	Crystal structure of IDO1 in complex with Apoxidole-1 分子名称: Indoleamine 2,3-dioxygenase 1, O1-tert-butyl O2-ethyl O5-methyl (E,5R)-5-(1-methylindol-2-yl)-5-[(4-methylphenyl)sulfonylamino]pent-2-ene-1,2,5-tricarboxylate, O2-tert-butyl O3-ethyl O6-methyl (2S,6R)-6-(1-methylindol-2-yl)-2,5-dihydro-1H-pyridine-2,3,6-tricarboxylate, ... 著者 Dotsch, L, Ziegler, S, Waldmann, H, Gasper, R. 登録日 2022-07-05 公開日 2022-08-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Identification of a Novel Pseudo-Natural Product Type IV IDO1 Inhibitor Chemotype. Angew.Chem.Int.Ed.Engl., 61, 2022
2EG8	The crystal structure of E. coli dihydroorotase complexed with 5-fluoroorotic acid 分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, Dihydroorotase, ZINC ION 著者 Lee, M, Maher, M.J, Guss, J.M. 登録日 2007-02-28 公開日 2007-07-03 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structures of Ligand-free and Inhibitor Complexes of Dihydroorotase from Escherichia coli: Implications for Loop Movement in Inhibitor Design J.Mol.Biol., 370, 2007
6I0M	Structure of human IMP dehydrogenase, isoform 2, bound to GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, Inosine-5'-monophosphate dehydrogenase 2, ... 著者 Buey, R.M, Fernandez-Justel, D, Revuelta, J.L. 登録日 2018-10-26 公開日 2019-01-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.567 Å) 主引用文献 A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity. J. Mol. Biol., 431, 2019
6J3C	Crystal structure of human DHODH in complex with inhibitor 1291 分子名称: (6R)-1-[4-[3-(dimethylamino)phenyl]-3,5-bis(fluoranyl)phenyl]-6-propan-2-yl-6,7-dihydro-5H-benzotriazol-4-one, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... 著者 Yu, Y, Chen, Q. 登録日 2019-01-04 公開日 2019-08-21 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.851 Å) 主引用文献 A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode. Febs Open Bio, 9, 2019
6I0O	Structure of human IMP dehydrogenase, isoform 2, bound to GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase 2, SULFATE ION 著者 Buey, R.M, Fernandez-Justel, D, Revuelta, J.L. 登録日 2018-10-26 公開日 2019-01-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.623 Å) 主引用文献 A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity. J. Mol. Biol., 431, 2019
7CA1	Crystal structure of dihydroorotase in complex with plumbagin from Saccharomyces cerevisiae 分子名称: (2S)-2-hydroxybutanedioic acid, 5-hydroxy-2-methylnaphthalene-1,4-dione, Dihydroorotase, ... 著者 Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. 登録日 2020-06-08 公開日 2021-06-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Plumbagin, a Natural Product with Potent Anticancer Activities, Binds to and Inhibits Dihydroorotase, a Key Enzyme in Pyrimidine Biosynthesis. Int J Mol Sci, 22, 2021
6L0I	Crystal structure of dihydroorotase in complex with malate at pH6.5 from Saccharomyces cerevisiae 分子名称: (2S)-2-hydroxybutanedioic acid, Dihydroorotase, ZINC ION 著者 Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. 登録日 2019-09-26 公開日 2020-12-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil. Biochem.Biophys.Res.Commun., 551, 2021
6L0F	Crystal structure of dihydroorotase in complex with 5-Aminouracil from Saccharomyces cerevisiae 分子名称: 5-AMINO-1H-PYRIMIDINE-2,4-DIONE, Dihydroorotase, ZINC ION 著者 Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. 登録日 2019-09-26 公開日 2020-12-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.26 Å) 主引用文献 Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil. Biochem.Biophys.Res.Commun., 551, 2021
6L0K	Crystal structure of dihydroorotase in complex with malate at pH9 from Saccharomyces cerevisiae 分子名称: (2S)-2-hydroxybutanedioic acid, Dihydroorotase, ZINC ION 著者 Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. 登録日 2019-09-26 公開日 2020-12-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil. Biochem.Biophys.Res.Commun., 551, 2021
6L0H	Crystal structure of dihydroorotase in complex with malate at pH7 from Saccharomyces cerevisiae 分子名称: (2S)-2-hydroxybutanedioic acid, Dihydroorotase, ZINC ION 著者 Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. 登録日 2019-09-26 公開日 2020-12-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.054 Å) 主引用文献 Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil. Biochem.Biophys.Res.Commun., 551, 2021
2EG6	The crystal structure of the ligand-free dihydroorotase from E. coli 分子名称: Dihydroorotase, ZINC ION 著者 Lee, M, Maher, M.J, Guss, J.M. 登録日 2007-02-28 公開日 2007-07-03 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structures of Ligand-free and Inhibitor Complexes of Dihydroorotase from Escherichia coli: Implications for Loop Movement in Inhibitor Design J.Mol.Biol., 370, 2007
2EG7	The crystal structure of E. coli dihydroorotase complexed with HDDP 分子名称: 2-OXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4,6-DICARBOXYLIC ACID, Dihydroorotase, ZINC ION 著者 Lee, M, Maher, M.J, Guss, J.M. 登録日 2007-02-28 公開日 2007-07-03 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structures of Ligand-free and Inhibitor Complexes of Dihydroorotase from Escherichia coli: Implications for Loop Movement in Inhibitor Design J.Mol.Biol., 370, 2007

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