6J3C

Crystal structure of human DHODH in complex with inhibitor 1291

Summary for 6J3C

• Entry DOI: 10.2210/pdb6j3c/pdb
• Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, SULFATE ION, FLAVIN MONONUCLEOTIDE, ... (7 entities in total)
• Functional Keywords: dhodh, inhibitor, complex, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 41361.90

Authors

Yu, Y.,Chen, Q. (deposition date: 2019-01-04, release date: 2019-08-21, Last modification date: 2024-03-27)

• Primary citation: Zeng, T.,Zuo, Z.,Luo, Y.,Zhao, Y.,Yu, Y.,Chen, Q.; A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.; Febs Open Bio, 9:1348-1354, 2019; PubMed: 31087527; DOI: 10.1002/2211-5463.12658

Experimental method

X-RAY DIFFRACTION (1.851 Å)