7CA1
Crystal structure of dihydroorotase in complex with plumbagin from Saccharomyces cerevisiae
Summary for 7CA1
Entry DOI | 10.2210/pdb7ca1/pdb |
Related | 6L0A 6L0B |
Descriptor | Dihydroorotase, (2S)-2-hydroxybutanedioic acid, ZINC ION, ... (4 entities in total) |
Functional Keywords | dihydropyrimidinase, dihydroorotase, metalloenzyme, hydrolase |
Biological source | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Total number of polymer chains | 4 |
Total formula weight | 167081.22 |
Authors | Guan, H.H.,Huang, Y.H.,Huang, C.Y.,Chen, C.J. (deposition date: 2020-06-08, release date: 2021-06-09, Last modification date: 2023-11-29) |
Primary citation | Guan, H.H.,Huang, Y.H.,Lin, E.S.,Chen, C.J.,Huang, C.Y. Plumbagin, a Natural Product with Potent Anticancer Activities, Binds to and Inhibits Dihydroorotase, a Key Enzyme in Pyrimidine Biosynthesis. Int J Mol Sci, 22:-, 2021 Cited by PubMed: 34202294DOI: 10.3390/ijms22136861 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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