4FFX

Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency Associated Mutation

Summary for 4FFX

Entry DOI	10.2210/pdb4ffx/pdb
Related	2J91 2VD6 4FFQ
Descriptor	Adenylosuccinate lyase (2 entities in total)
Functional Keywords	purine biosynthesis, lyase, disease mutation, purine metabolism
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	221094.25
Authors	Deaton, M.K.,Ray, S.P.,Capodagli, G.C.,Calkins, L.A.F.,Sawle, L.,Ghosh, K.,Patterson, D.,Pegan, S.D. (deposition date: 2012-06-01, release date: 2012-08-01, Last modification date: 2023-09-13)
Primary citation	Ray, S.P.,Deaton, M.K.,Capodagli, G.C.,Calkins, L.A.,Sawle, L.,Ghosh, K.,Patterson, D.,Pegan, S.D. Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency-Associated Mutation. Biochemistry, 51:6701-6713, 2012 Cited by PubMed: 22812634 DOI: 10.1021/bi300796y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation