4FFX

Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency Associated Mutation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Adenylosuccinate lyase	polymer	487	55273.6	4	UniProt (P30566) Pfam (PF00206) Pfam (PF10397)	Homo sapiens (human)	ASL, Adenylosuccinase, ASase
2	E, F, G, H (A, B, C, D)	water	water		18.0	214	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 484 (UniProt: P30566)

PDB	External Database	Details
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Arg 63	Gln 63	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	221094.2
All*	Total formula weight	221094.2

*Water molecules are not included.