6I0M
Structure of human IMP dehydrogenase, isoform 2, bound to GDP
Summary for 6I0M
| Entry DOI | 10.2210/pdb6i0m/pdb |
| Descriptor | Inosine-5'-monophosphate dehydrogenase 2, GUANOSINE-5'-MONOPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
| Functional Keywords | oxidoreductase, de novo guanine nucleotide biosynthesis, biosynthetic protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 116660.55 |
| Authors | Buey, R.M.,Fernandez-Justel, D.,Revuelta, J.L. (deposition date: 2018-10-26, release date: 2019-01-30, Last modification date: 2024-01-24) |
| Primary citation | Fernandez-Justel, D.,Nunez, R.,Martin-Benito, J.,Jimeno, D.,Gonzalez-Lopez, A.,Soriano, E.M.,Revuelta, J.L.,Buey, R.M. A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity. J. Mol. Biol., 431:956-969, 2019 Cited by PubMed: 30664871DOI: 10.1016/j.jmb.2019.01.020 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.567 Å) |
Structure validation
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