8OFW

Crystal structure of the full-length dihydroorotate dehydrogenase from Mycobacterium tuberculosis

Summary for 8OFW

Entry DOI	10.2210/pdb8ofw/pdb
Descriptor	Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE (2 entities in total)
Functional Keywords	dihydroorotate dehydrogenase, flavoenzyme; pyrimidine biosynthesis, oxidoreductase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	81352.56
Authors	Alberti, M.,Ferraris, D.M.,Miggiano, R. (deposition date: 2023-03-17, release date: 2023-09-06)
Primary citation	Alberti, M.,Sainas, S.,Ronchi, E.,Lolli, M.L.,Boschi, D.,Rizzi, M.,Ferraris, D.M.,Miggiano, R. Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor. Febs Lett., 597:2119-2132, 2023 Cited by PubMed: 37278160 DOI: 10.1002/1873-3468.14680 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.8 Å)

Structure validation