6I0O

Structure of human IMP dehydrogenase, isoform 2, bound to GTP

Summary for 6I0O

Entry DOI	10.2210/pdb6i0o/pdb
Related	6I0M
Descriptor	Inosine-5'-monophosphate dehydrogenase 2, GUANOSINE-5'-TRIPHOSPHATE, SULFATE ION, ... (4 entities in total)
Functional Keywords	oxidoreductase, de novo guanine nucleotide biosynthesis, biosynthetic protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	117950.99
Authors	Buey, R.M.,Fernandez-Justel, D.,Revuelta, J.L. (deposition date: 2018-10-26, release date: 2019-01-30, Last modification date: 2024-01-24)
Primary citation	Fernandez-Justel, D.,Nunez, R.,Martin-Benito, J.,Jimeno, D.,Gonzalez-Lopez, A.,Soriano, E.M.,Revuelta, J.L.,Buey, R.M. A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity. J. Mol. Biol., 431:956-969, 2019 Cited by PubMed: 30664871 DOI: 10.1016/j.jmb.2019.01.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.623 Å)

Structure validation