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8T10
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TRPV1 in nanodisc bound with two LPA molecules in opposite monomers
分子名称: (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ...
著者Arnold, W.R, Julius, D, Cheng, Y.
登録日2023-06-01
公開日2024-05-08
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 2024
8T3M
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TRPV1 in nanodisc bound with 3 LPA molecules
分子名称: (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ...
著者Arnold, W.R, Julius, D, Cheng, Y.
登録日2023-06-07
公開日2024-05-08
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 2024
8T0E
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TRPV1 in Nanodisc not bound with lysophosphatidic acid (apo)
分子名称: (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1
著者Arnold, W.R, Cheng, Y.
登録日2023-05-31
公開日2024-05-08
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 2024
8T0Y
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BU of 8t0y by Molmil
TRPV1 in nanodisc bound with one LPA in one monomer
分子名称: (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ...
著者Arnold, W.R, Cheng, Y.
登録日2023-06-01
公開日2024-05-08
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 2024
7YID
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Human KCNH5 closed state 1
分子名称: POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5
著者Zhang, M.F.
登録日2022-07-16
公開日2023-04-05
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel.
Nat Commun, 14, 2023
8T4Y
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Human HCN1 F186C S264C C309A bound to cAMP, reconstituted in LMNG + SPL
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
著者Burtscher, V, Mount, J, Cowgill, J, Chang, Y, Bickel, K, Yuan, P, Chanda, B.
登録日2023-06-12
公開日2024-06-19
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.58 Å)
主引用文献Structural basis for hyperpolarization-dependent opening of human HCN1 channel.
Nat Commun, 15, 2024
8T50
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Open human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
著者Burtscher, V, Mount, J, Cowgill, J, Chang, Y, Bickel, K, Yuan, P, Chanda, B.
登録日2023-06-12
公開日2024-07-03
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural basis for hyperpolarization-dependent opening of human HCN1 channel.
Nat Commun, 15, 2024
8T4M
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Closed human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
著者Burtscher, V, Mount, J, Cowgill, J, Chang, Y, Bickel, K, Yuan, P, Chanda, B.
登録日2023-06-09
公開日2024-06-12
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.16 Å)
主引用文献Structural basis for hyperpolarization-dependent opening of human HCN1 channel.
Nat Commun, 15, 2024
7WDB
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BU of 7wdb by Molmil
Human TRPC5 channel in complex with riluzole
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine, CALCIUM ION, ...
著者Chen, L, Wei, M, Yang, Y.
登録日2021-12-21
公開日2022-04-13
最終更新日2022-08-03
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Structural identification of riluzole-binding site on human TRPC5.
Cell Discov, 8, 2022
7W5Z
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BU of 7w5z by Molmil
Cryo-EM structure of Tetrahymena thermophila mitochondrial complex IV, composite dimer model
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-oxoglutarate/malate carrier protein, CARDIOLIPIN, ...
著者Zhou, L, Maldonado, M, Padavannil, A, Letts, J.
登録日2021-11-30
公開日2022-04-06
最終更新日2022-06-01
実験手法ELECTRON MICROSCOPY (3.02 Å)
主引用文献Structures of Tetrahymena 's respiratory chain reveal the diversity of eukaryotic core metabolism.
Science, 376, 2022
7LQY
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Structure of squirrel TRPV1 in apo state
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoinositol, CHLORIDE ION, ...
著者Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
登録日2021-02-15
公開日2021-04-21
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.19 Å)
主引用文献Extracellular cap domain is an essential component of the TRPV1 gating mechanism.
Nat Commun, 12, 2021
7LR0
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BU of 7lr0 by Molmil
Structure of squirrel TRPV1 in complex with capsaicin
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, Osm-9-like TRP channel 1, ...
著者Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I.
登録日2021-02-15
公開日2021-04-21
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.81 Å)
主引用文献Extracellular cap domain is an essential component of the TRPV1 gating mechanism.
Nat Commun, 12, 2021
7YG5
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BU of 7yg5 by Molmil
Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the topiramate-bound state
分子名称: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Gao, Y, Zhao, Y.
登録日2022-07-11
公開日2023-11-29
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural insights into the allosteric effects of the antiepileptic drug topiramate on the Ca V 2.3 channel.
Biochem.Biophys.Res.Commun., 725, 2024
7LQZ
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BU of 7lqz by Molmil
Structure of squirrel TRPV1 in complex with RTX
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Osm-9-like TRP channel 1, SODIUM ION, ...
著者Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I.
登録日2021-02-15
公開日2021-04-21
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.41 Å)
主引用文献Extracellular cap domain is an essential component of the TRPV1 gating mechanism.
Nat Commun, 12, 2021
7NP3
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cAMP-free rabbit HCN4 stabilized in LMNG-CHS detergent mixture
分子名称: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
著者Giese, H.M, Chaves-Sanjuan, A, Saponaro, A, Clarke, O, Bolognesi, M, Mancia, F, Hendrickson, W.A, Thiel, G, Santoro, B, Moroni, A.
登録日2021-02-26
公開日2021-08-11
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Gating movements and ion permeation in HCN4 pacemaker channels.
Mol.Cell, 81, 2021
7MZ5
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BU of 7mz5 by Molmil
Cryo-EM structure of RTX-bound full-length TRPV1 in C2 state
分子名称: SODIUM ION, Transient receptor potential cation channel subfamily V member 1, resiniferatoxin
著者Zhang, K, Julius, D, Cheng, Y.
登録日2021-05-24
公開日2021-09-22
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (2.76 Å)
主引用文献Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
7MZ6
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BU of 7mz6 by Molmil
Cryo-EM structure of minimal TRPV1 with 1 perturbed PI
分子名称: (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate, (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, ...
著者Zhang, K, Julius, D, Cheng, Y.
登録日2021-05-24
公開日2021-09-22
最終更新日2021-10-13
実験手法ELECTRON MICROSCOPY (2.91 Å)
主引用文献Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
7MZB
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BU of 7mzb by Molmil
Cryo-EM structure of minimal TRPV1 with 3 bound RTX and 1 perturbed PI
分子名称: (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ...
著者Zhang, K, Julius, D, Cheng, Y.
登録日2021-05-24
公開日2021-09-22
最終更新日2021-10-13
実験手法ELECTRON MICROSCOPY (3.72 Å)
主引用文献Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
7MZC
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BU of 7mzc by Molmil
Cryo-EM structure of minimal TRPV1 with RTX bound in C1 state
分子名称: SODIUM ION, Transient receptor potential cation channel subfamily V member 1, resiniferatoxin
著者Zhang, K, Julius, D, Cheng, Y.
登録日2021-05-24
公開日2021-09-22
最終更新日2021-10-13
実験手法ELECTRON MICROSCOPY (3.03 Å)
主引用文献Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
7MZ9
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BU of 7mz9 by Molmil
Cryo-EM structure of minimal TRPV1 with 1 partially bound RTX
分子名称: (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ...
著者Zhang, K, Julius, D, Cheng, Y.
登録日2021-05-24
公開日2021-09-22
最終更新日2021-10-13
実験手法ELECTRON MICROSCOPY (3.18 Å)
主引用文献Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
7MZA
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BU of 7mza by Molmil
Cryo-EM structure of minimal TRPV1 with 2 bound RTX in adjacent pockets
分子名称: (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ...
著者Zhang, K, Julius, D, Cheng, Y.
登録日2021-05-24
公開日2021-09-22
最終更新日2021-10-13
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
7MZE
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BU of 7mze by Molmil
Cryo-EM structure of minimal TRPV1 with 2 bound RTX in opposite pockets
分子名称: (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ...
著者Zhang, K, Julius, D, Cheng, Y.
登録日2021-05-24
公開日2021-09-22
最終更新日2021-10-13
実験手法ELECTRON MICROSCOPY (3.42 Å)
主引用文献Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
7MZ7
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BU of 7mz7 by Molmil
Cryo-EM structure of minimal TRPV1 with 4 partially bound RTX
分子名称: SODIUM ION, Transient receptor potential cation channel subfamily V member 1, resiniferatoxin
著者Zhang, K, Julius, D, Cheng, Y.
登録日2021-05-24
公開日2021-09-22
最終更新日2021-10-13
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
7MZD
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BU of 7mzd by Molmil
Cryo-EM structure of minimal TRPV1 with RTX bound in C2 state
分子名称: SODIUM ION, Transient receptor potential cation channel subfamily V member 1, resiniferatoxin
著者Zhang, K, Julius, D, Cheng, Y.
登録日2021-05-24
公開日2021-09-22
最終更新日2021-10-13
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
7N17
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BU of 7n17 by Molmil
Structure of TAX-4_R421W apo open state
分子名称: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel
著者Zheng, X, Li, H, Hu, Z, Su, D, Yang, J.
登録日2021-05-27
公開日2022-03-16
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural and functional characterization of an achromatopsia-associated mutation in a phototransduction channel.
Commun Biol, 5, 2022

223532

件を2024-08-07に公開中

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