8T50

Open human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL

Summary for 8T50

Entry DOI	10.2210/pdb8t50/pdb
Related	6UQF 8T4M
EMDB information	41036 41040 41041
Descriptor	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE (2 entities in total)
Functional Keywords	membrane protein, ion channel, transport protein
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	396804.10
Authors	Burtscher, V.,Mount, J.,Cowgill, J.,Chang, Y.,Bickel, K.,Yuan, P.,Chanda, B. (deposition date: 2023-06-12, release date: 2024-07-03)
Primary citation	Burtscher, V.,Mount, J.,Huang, J.,Cowgill, J.,Chang, Y.,Bickel, K.,Chen, J.,Yuan, P.,Chanda, B. Structural basis for hyperpolarization-dependent opening of human HCN1 channel. Nat Commun, 15:5216-5216, 2024 Cited by PubMed: 38890331 DOI: 10.1038/s41467-024-49599-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation