8T50
Open human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (C, B, A, D) | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | polymer | 890 | 98871.8 | 4 | UniProt (O60741) Pfam (PF08412) Pfam (PF00520) Pfam (PF00027) | Homo sapiens (human) | Brain cyclic nucleotide-gated channel 1,BCNG-1 |
| 2 | E, F, G, H (C, B, A, D) | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | non-polymer | 329.2 | 4 | Chemie (CMP) |
Sequence modifications
C, B, A, D: 1 - 890 (UniProt: O60741)
| PDB | External Database | Details |
|---|---|---|
| Cys 186 | Phe 186 | engineered mutation |
| Cys 264 | Ser 264 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 395487.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1316.8 | |
| All* | Total formula weight | 396804.1 |
