8T50
Open human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (C, B, A, D) | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | polymer | 890 | 98871.8 | 4 | UniProt (O60741) Pfam (PF08412) Pfam (PF00520) Pfam (PF00027) | Homo sapiens (human) | Brain cyclic nucleotide-gated channel 1,BCNG-1 |
| 2 | E, F, G, H (C, B, A, D) | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | non-polymer | 329.2 | 4 | Chemie (CMP) PubChem (6076) PubChem (216878) PubChem (3080770) PubChem (3246347) PubChem (6603718) PubChem (6713792) PubChem (6714006) PubChem (12071879) PubChem (12866365) PubChem (23902375) PubChem (25322948) PubChem (40467852) PubChem (44629928) PubChem (176488666) PubChem (25322946) PubChem (59350541) PubChem (274) PubChem (6604194) PubChem (56973690) PubChem (163043517) PubChem (59909322) PubChem (59968988) PubChem (70878457) PubChem (124132380) PubChem (129317551) PubChem (131841987) PubChem (134693155) PubChem (138107790) PubChem (163043518) |
Sequence modifications
C, B, A, D: 1 - 890 (UniProt: O60741)
| PDB | External Database | Details |
|---|---|---|
| Cys 186 | Phe 186 | engineered mutation |
| Cys 264 | Ser 264 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 395487.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1316.8 | |
| All* | Total formula weight | 396804.1 |
