Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8T50

Open human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003254biological_processregulation of membrane depolarization
A0005216molecular_functionmonoatomic ion channel activity
A0005222molecular_functionintracellularly cAMP-activated cation channel activity
A0005248molecular_functionvoltage-gated sodium channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005272molecular_functionsodium channel activity
A0005515molecular_functionprotein binding
A0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
A0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006814biological_processsodium ion transport
A0009986cellular_componentcell surface
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0022843molecular_functionvoltage-gated monoatomic cation channel activity
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030552molecular_functioncAMP binding
A0032590cellular_componentdendrite membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0035458biological_processcellular response to interferon-beta
A0035725biological_processsodium ion transmembrane transport
A0036477cellular_componentsomatodendritic compartment
A0042391biological_processregulation of membrane potential
A0042711biological_processmaternal behavior
A0042802molecular_functionidentical protein binding
A0043025cellular_componentneuronal cell body
A0043198cellular_componentdendritic shaft
A0043679cellular_componentaxon terminus
A0045211cellular_componentpostsynaptic membrane
A0045759biological_processnegative regulation of action potential
A0048787cellular_componentpresynaptic active zone membrane
A0051289biological_processprotein homotetramerization
A0051592biological_processresponse to calcium ion
A0055085biological_processtransmembrane transport
A0060078biological_processregulation of postsynaptic membrane potential
A0071320biological_processcellular response to cAMP
A0071805biological_processpotassium ion transmembrane transport
A0086091biological_processregulation of heart rate by cardiac conduction
A0097440cellular_componentapical dendrite
A0098719biological_processsodium ion import across plasma membrane
A0098855cellular_componentHCN channel complex
A0098907biological_processregulation of SA node cell action potential
A0098978cellular_componentglutamatergic synapse
A0140232molecular_functionintracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential
A1902065biological_processresponse to L-glutamate
A1902630biological_processregulation of membrane hyperpolarization
A1902632biological_processpositive regulation of membrane hyperpolarization
A1990573biological_processpotassium ion import across plasma membrane
B0000166molecular_functionnucleotide binding
B0003254biological_processregulation of membrane depolarization
B0005216molecular_functionmonoatomic ion channel activity
B0005222molecular_functionintracellularly cAMP-activated cation channel activity
B0005248molecular_functionvoltage-gated sodium channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005272molecular_functionsodium channel activity
B0005515molecular_functionprotein binding
B0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
B0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006814biological_processsodium ion transport
B0009986cellular_componentcell surface
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0022843molecular_functionvoltage-gated monoatomic cation channel activity
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030552molecular_functioncAMP binding
B0032590cellular_componentdendrite membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0035458biological_processcellular response to interferon-beta
B0035725biological_processsodium ion transmembrane transport
B0036477cellular_componentsomatodendritic compartment
B0042391biological_processregulation of membrane potential
B0042711biological_processmaternal behavior
B0042802molecular_functionidentical protein binding
B0043025cellular_componentneuronal cell body
B0043198cellular_componentdendritic shaft
B0043679cellular_componentaxon terminus
B0045211cellular_componentpostsynaptic membrane
B0045759biological_processnegative regulation of action potential
B0048787cellular_componentpresynaptic active zone membrane
B0051289biological_processprotein homotetramerization
B0051592biological_processresponse to calcium ion
B0055085biological_processtransmembrane transport
B0060078biological_processregulation of postsynaptic membrane potential
B0071320biological_processcellular response to cAMP
B0071805biological_processpotassium ion transmembrane transport
B0086091biological_processregulation of heart rate by cardiac conduction
B0097440cellular_componentapical dendrite
B0098719biological_processsodium ion import across plasma membrane
B0098855cellular_componentHCN channel complex
B0098907biological_processregulation of SA node cell action potential
B0098978cellular_componentglutamatergic synapse
B0140232molecular_functionintracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential
B1902065biological_processresponse to L-glutamate
B1902630biological_processregulation of membrane hyperpolarization
B1902632biological_processpositive regulation of membrane hyperpolarization
B1990573biological_processpotassium ion import across plasma membrane
C0000166molecular_functionnucleotide binding
C0003254biological_processregulation of membrane depolarization
C0005216molecular_functionmonoatomic ion channel activity
C0005222molecular_functionintracellularly cAMP-activated cation channel activity
C0005248molecular_functionvoltage-gated sodium channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005272molecular_functionsodium channel activity
C0005515molecular_functionprotein binding
C0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
C0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0006814biological_processsodium ion transport
C0009986cellular_componentcell surface
C0016020cellular_componentmembrane
C0016323cellular_componentbasolateral plasma membrane
C0022843molecular_functionvoltage-gated monoatomic cation channel activity
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0030552molecular_functioncAMP binding
C0032590cellular_componentdendrite membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0035458biological_processcellular response to interferon-beta
C0035725biological_processsodium ion transmembrane transport
C0036477cellular_componentsomatodendritic compartment
C0042391biological_processregulation of membrane potential
C0042711biological_processmaternal behavior
C0042802molecular_functionidentical protein binding
C0043025cellular_componentneuronal cell body
C0043198cellular_componentdendritic shaft
C0043679cellular_componentaxon terminus
C0045211cellular_componentpostsynaptic membrane
C0045759biological_processnegative regulation of action potential
C0048787cellular_componentpresynaptic active zone membrane
C0051289biological_processprotein homotetramerization
C0051592biological_processresponse to calcium ion
C0055085biological_processtransmembrane transport
C0060078biological_processregulation of postsynaptic membrane potential
C0071320biological_processcellular response to cAMP
C0071805biological_processpotassium ion transmembrane transport
C0086091biological_processregulation of heart rate by cardiac conduction
C0097440cellular_componentapical dendrite
C0098719biological_processsodium ion import across plasma membrane
C0098855cellular_componentHCN channel complex
C0098907biological_processregulation of SA node cell action potential
C0098978cellular_componentglutamatergic synapse
C0140232molecular_functionintracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential
C1902065biological_processresponse to L-glutamate
C1902630biological_processregulation of membrane hyperpolarization
C1902632biological_processpositive regulation of membrane hyperpolarization
C1990573biological_processpotassium ion import across plasma membrane
D0000166molecular_functionnucleotide binding
D0003254biological_processregulation of membrane depolarization
D0005216molecular_functionmonoatomic ion channel activity
D0005222molecular_functionintracellularly cAMP-activated cation channel activity
D0005248molecular_functionvoltage-gated sodium channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005272molecular_functionsodium channel activity
D0005515molecular_functionprotein binding
D0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
D0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006814biological_processsodium ion transport
D0009986cellular_componentcell surface
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0022843molecular_functionvoltage-gated monoatomic cation channel activity
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0030552molecular_functioncAMP binding
D0032590cellular_componentdendrite membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0035458biological_processcellular response to interferon-beta
D0035725biological_processsodium ion transmembrane transport
D0036477cellular_componentsomatodendritic compartment
D0042391biological_processregulation of membrane potential
D0042711biological_processmaternal behavior
D0042802molecular_functionidentical protein binding
D0043025cellular_componentneuronal cell body
D0043198cellular_componentdendritic shaft
D0043679cellular_componentaxon terminus
D0045211cellular_componentpostsynaptic membrane
D0045759biological_processnegative regulation of action potential
D0048787cellular_componentpresynaptic active zone membrane
D0051289biological_processprotein homotetramerization
D0051592biological_processresponse to calcium ion
D0055085biological_processtransmembrane transport
D0060078biological_processregulation of postsynaptic membrane potential
D0071320biological_processcellular response to cAMP
D0071805biological_processpotassium ion transmembrane transport
D0086091biological_processregulation of heart rate by cardiac conduction
D0097440cellular_componentapical dendrite
D0098719biological_processsodium ion import across plasma membrane
D0098855cellular_componentHCN channel complex
D0098907biological_processregulation of SA node cell action potential
D0098978cellular_componentglutamatergic synapse
D0140232molecular_functionintracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential
D1902065biological_processresponse to L-glutamate
D1902630biological_processregulation of membrane hyperpolarization
D1902632biological_processpositive regulation of membrane hyperpolarization
D1990573biological_processpotassium ion import across plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00888
Number of Residues17
DetailsCNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrEGAvGKkMYFIqhG
ChainResidueDetails
CILE502-GLY518
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues48
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues52
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues84
DetailsIntramembrane: {"description":"Pore-forming; Name=Segment H5","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues16
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"O88704","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

PDB statisticsPDBj update infoContact PDBjnumon