8T4Y

Human HCN1 F186C S264C C309A bound to cAMP, reconstituted in LMNG + SPL

Summary for 8T4Y

• Entry DOI: 10.2210/pdb8t4y/pdb
• Related: 8T4M
• EMDB information: 41036 41040 41041
• Descriptor: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE (2 entities in total)
• Functional Keywords: membrane protein, ion channel, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 396675.86

Authors

Burtscher, V.,Mount, J.,Cowgill, J.,Chang, Y.,Bickel, K.,Yuan, P.,Chanda, B. (deposition date: 2023-06-12, release date: 2024-06-19, Last modification date: 2024-07-03)

• Primary citation: Burtscher, V.,Mount, J.,Huang, J.,Cowgill, J.,Chang, Y.,Bickel, K.,Chen, J.,Yuan, P.,Chanda, B.; Structural basis for hyperpolarization-dependent opening of human HCN1 channel.; Nat Commun, 15:5216-5216, 2024; PubMed: 38890331; DOI: 10.1038/s41467-024-49599-x

Experimental method

ELECTRON MICROSCOPY (3.58 Å)