7MZE

Cryo-EM structure of minimal TRPV1 with 2 bound RTX in opposite pockets

Summary for 7MZE

Entry DOI	10.2210/pdb7mze/pdb
EMDB information	24083 24084 24085 24086 24087 24088 24089 24090 24091
Descriptor	Transient receptor potential cation channel subfamily V member 1, (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, ... (4 entities in total)
Functional Keywords	trp channel, cryo-em, nanodisc, stoichiometry, transport protein
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	4
Total formula weight	294547.08
Authors	Zhang, K.,Julius, D.,Cheng, Y. (deposition date: 2021-05-24, release date: 2021-09-22, Last modification date: 2021-10-13)
Primary citation	Zhang, K.,Julius, D.,Cheng, Y. Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184:5138-, 2021 Cited by PubMed: 34496225 DOI: 10.1016/j.cell.2021.08.012 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.42 Å)

Structure validation