7LR0

Structure of squirrel TRPV1 in complex with capsaicin

Summary for 7LR0

Entry DOI	10.2210/pdb7lr0/pdb
Related	7LQY 7LQZ
EMDB information	23491 23492 23493
Descriptor	Osm-9-like TRP channel 1, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, ... (4 entities in total)
Functional Keywords	transient receptor potential v family member 1, trp channel, trpv1 full length, trpv1 wild type, capsaicin, membrane protein
Biological source	Ictidomys tridecemlineatus (Thirteen-lined ground squirrel, Spermophilus tridecemlineatus)
Total number of polymer chains	4
Total formula weight	406137.89
Authors	Neuberger, A.,Nadezhdin, K.D.,Sobolevsky, A.I. (deposition date: 2021-02-15, release date: 2021-04-21, Last modification date: 2024-03-06)
Primary citation	Nadezhdin, K.D.,Neuberger, A.,Nikolaev, Y.A.,Murphy, L.A.,Gracheva, E.O.,Bagriantsev, S.N.,Sobolevsky, A.I. Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nat Commun, 12:2154-2154, 2021 Cited by PubMed: 33846324 DOI: 10.1038/s41467-021-22507-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.81 Å)

Structure validation