7LR0
Structure of squirrel TRPV1 in complex with capsaicin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0032591 | cellular_component | dendritic spine membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034605 | biological_process | cellular response to heat |
| A | 0043005 | cellular_component | neuron projection |
| A | 0045211 | cellular_component | postsynaptic membrane |
| A | 0050965 | biological_process | detection of temperature stimulus involved in sensory perception of pain |
| A | 0051219 | molecular_function | phosphoprotein binding |
| A | 0071468 | biological_process | cellular response to acidic pH |
| A | 0097603 | molecular_function | temperature-gated ion channel activity |
| A | 0098703 | biological_process | calcium ion import across plasma membrane |
| A | 0098982 | cellular_component | GABA-ergic synapse |
| A | 1901594 | biological_process | response to capsazepine |
| B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0032591 | cellular_component | dendritic spine membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0034605 | biological_process | cellular response to heat |
| B | 0043005 | cellular_component | neuron projection |
| B | 0045211 | cellular_component | postsynaptic membrane |
| B | 0050965 | biological_process | detection of temperature stimulus involved in sensory perception of pain |
| B | 0051219 | molecular_function | phosphoprotein binding |
| B | 0071468 | biological_process | cellular response to acidic pH |
| B | 0097603 | molecular_function | temperature-gated ion channel activity |
| B | 0098703 | biological_process | calcium ion import across plasma membrane |
| B | 0098982 | cellular_component | GABA-ergic synapse |
| B | 1901594 | biological_process | response to capsazepine |
| C | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0005262 | molecular_function | calcium channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0032591 | cellular_component | dendritic spine membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0034605 | biological_process | cellular response to heat |
| C | 0043005 | cellular_component | neuron projection |
| C | 0045211 | cellular_component | postsynaptic membrane |
| C | 0050965 | biological_process | detection of temperature stimulus involved in sensory perception of pain |
| C | 0051219 | molecular_function | phosphoprotein binding |
| C | 0071468 | biological_process | cellular response to acidic pH |
| C | 0097603 | molecular_function | temperature-gated ion channel activity |
| C | 0098703 | biological_process | calcium ion import across plasma membrane |
| C | 0098982 | cellular_component | GABA-ergic synapse |
| C | 1901594 | biological_process | response to capsazepine |
| D | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0005262 | molecular_function | calcium channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0032591 | cellular_component | dendritic spine membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0034605 | biological_process | cellular response to heat |
| D | 0043005 | cellular_component | neuron projection |
| D | 0045211 | cellular_component | postsynaptic membrane |
| D | 0050965 | biological_process | detection of temperature stimulus involved in sensory perception of pain |
| D | 0051219 | molecular_function | phosphoprotein binding |
| D | 0071468 | biological_process | cellular response to acidic pH |
| D | 0097603 | molecular_function | temperature-gated ion channel activity |
| D | 0098703 | biological_process | calcium ion import across plasma membrane |
| D | 0098982 | cellular_component | GABA-ergic synapse |
| D | 1901594 | biological_process | response to capsazepine |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue POV A 901 |
| Chain | Residue |
| A | POV902 |
| A | 4DY903 |
| A | POV905 |
| B | PHE657 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue POV A 902 |
| Chain | Residue |
| A | TYR633 |
| A | POV901 |
| B | LYS658 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue 4DY A 903 |
| Chain | Residue |
| A | PHE545 |
| A | THR552 |
| A | TYR556 |
| A | POV901 |
| B | PHE593 |
| B | LEU664 |
| B | LEU671 |
| A | SER514 |
| A | LEU517 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue POV A 904 |
| Chain | Residue |
| A | ASN439 |
| A | VAL442 |
| A | TYR443 |
| A | ARG493 |
| A | GLU515 |
| A | PHE518 |
| A | TYR557 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue POV A 905 |
| Chain | Residue |
| A | VAL510 |
| A | MET549 |
| A | ILE575 |
| A | LEU576 |
| A | POV901 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue POV A 906 |
| Chain | Residue |
| A | GLU480 |
| A | MET525 |
| A | SER528 |
| A | TYR532 |
| A | PHE533 |
| A | MET543 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue POV A 907 |
| Chain | Residue |
| A | TYR455 |
| B | MET583 |
| B | LEU587 |
| B | LEU590 |
| B | PHE591 |
| B | CYS636 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue POV A 908 |
| Chain | Residue |
| A | TYR437 |
| A | PHE440 |
| A | PHE561 |
| A | GLN563 |
| A | MET564 |
| B | CYS580 |
| B | MET583 |
| B | PHE584 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue POV A 909 |
| Chain | Residue |
| A | PHE657 |
| D | POV903 |
| D | 4DY904 |
| D | POV906 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue POV B 901 |
| Chain | Residue |
| B | POV902 |
| B | 4DY903 |
| B | POV905 |
| C | PHE657 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue POV B 902 |
| Chain | Residue |
| B | TYR633 |
| B | POV901 |
| C | LYS658 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue 4DY B 903 |
| Chain | Residue |
| B | SER514 |
| B | LEU517 |
| B | PHE545 |
| B | THR552 |
| B | TYR556 |
| B | POV901 |
| C | PHE593 |
| C | LEU664 |
| C | LEU671 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue POV B 904 |
| Chain | Residue |
| B | ASN439 |
| B | VAL442 |
| B | TYR443 |
| B | ARG493 |
| B | GLU515 |
| B | PHE518 |
| B | TYR557 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue POV B 905 |
| Chain | Residue |
| B | MET549 |
| B | ILE575 |
| B | LEU576 |
| B | POV901 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue POV B 906 |
| Chain | Residue |
| B | GLU480 |
| B | MET525 |
| B | SER528 |
| B | TYR532 |
| B | PHE533 |
| B | MET543 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue POV B 907 |
| Chain | Residue |
| B | TYR455 |
| C | MET583 |
| C | LEU587 |
| C | LEU590 |
| C | PHE591 |
| C | CYS636 |
| site_id | AD8 |
| Number of Residues | 8 |
| Details | binding site for residue POV B 908 |
| Chain | Residue |
| B | TYR437 |
| B | PHE440 |
| B | PHE561 |
| B | GLN563 |
| B | MET564 |
| C | CYS580 |
| C | MET583 |
| C | PHE584 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue POV C 901 |
| Chain | Residue |
| C | POV902 |
| C | 4DY903 |
| C | POV905 |
| D | PHE657 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue POV C 902 |
| Chain | Residue |
| C | TYR633 |
| C | POV901 |
| D | LYS658 |
| site_id | AE2 |
| Number of Residues | 9 |
| Details | binding site for residue 4DY C 903 |
| Chain | Residue |
| C | SER514 |
| C | LEU517 |
| C | PHE545 |
| C | THR552 |
| C | TYR556 |
| C | POV901 |
| D | PHE593 |
| D | LEU664 |
| D | LEU671 |
| site_id | AE3 |
| Number of Residues | 7 |
| Details | binding site for residue POV C 904 |
| Chain | Residue |
| C | ASN439 |
| C | VAL442 |
| C | TYR443 |
| C | ARG493 |
| C | GLU515 |
| C | PHE518 |
| C | TYR557 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue POV C 905 |
| Chain | Residue |
| C | MET549 |
| C | ILE575 |
| C | LEU576 |
| C | POV901 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue POV C 906 |
| Chain | Residue |
| C | GLU480 |
| C | MET525 |
| C | SER528 |
| C | TYR532 |
| C | PHE533 |
| C | MET543 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue POV C 907 |
| Chain | Residue |
| C | TYR455 |
| D | MET583 |
| D | LEU587 |
| D | LEU590 |
| D | PHE591 |
| D | CYS636 |
| site_id | AE7 |
| Number of Residues | 8 |
| Details | binding site for residue POV C 908 |
| Chain | Residue |
| C | TYR437 |
| C | PHE440 |
| C | PHE561 |
| C | GLN563 |
| C | MET564 |
| D | CYS580 |
| D | MET583 |
| D | PHE584 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue POV D 901 |
| Chain | Residue |
| A | MET583 |
| A | LEU587 |
| A | LEU590 |
| A | PHE591 |
| A | CYS636 |
| D | TYR455 |
| D | TYR456 |
| site_id | AE9 |
| Number of Residues | 8 |
| Details | binding site for residue POV D 902 |
| Chain | Residue |
| A | CYS580 |
| A | MET583 |
| A | PHE584 |
| D | TYR437 |
| D | PHE440 |
| D | PHE561 |
| D | GLN563 |
| D | MET564 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue POV D 903 |
| Chain | Residue |
| A | LYS658 |
| A | ALA659 |
| A | POV909 |
| D | TYR633 |
| site_id | AF2 |
| Number of Residues | 9 |
| Details | binding site for residue 4DY D 904 |
| Chain | Residue |
| A | PHE593 |
| A | LEU664 |
| A | LEU671 |
| A | POV909 |
| D | SER514 |
| D | LEU517 |
| D | PHE545 |
| D | THR552 |
| D | TYR556 |
| site_id | AF3 |
| Number of Residues | 7 |
| Details | binding site for residue POV D 905 |
| Chain | Residue |
| D | ASN439 |
| D | VAL442 |
| D | TYR443 |
| D | ARG493 |
| D | GLU515 |
| D | PHE518 |
| D | TYR557 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue POV D 906 |
| Chain | Residue |
| A | POV909 |
| D | MET549 |
| D | ILE575 |
| D | LEU576 |
| site_id | AF5 |
| Number of Residues | 6 |
| Details | binding site for residue POV D 907 |
| Chain | Residue |
| D | GLU480 |
| D | MET525 |
| D | SER528 |
| D | TYR532 |
| D | PHE533 |
| D | MET543 |
