7YG5

Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the topiramate-bound state

Summary for 7YG5

• Entry DOI: 10.2210/pdb7yg5/pdb
• EMDB information: 33808
• Descriptor: Voltage-dependent R-type calcium channel subunit alpha-1E, [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: voltage-gated calcium channel, cav2.3, complex, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 463732.16

Authors

Gao, Y.,Zhao, Y. (deposition date: 2022-07-11, release date: 2023-11-29)

• Primary citation: Gao, Y.,Zhao, Y.; Structural insights into allosteric effects of antiepileptic drug topiramate on CaV2.3 channel.; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3 Å)