7YG5
Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the topiramate-bound state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Voltage-dependent R-type calcium channel subunit alpha-1E | polymer | 2313 | 262056.0 | 1 | UniProt (Q15878) Pfam (PF00520) Pfam (PF16905) Pfam (PF08763) | Homo sapiens (human) | Brain calcium channel II,BII,Calcium channel,L type,alpha-1 polypeptide,isoform 6,Voltage-gated calcium channel subunit alpha Cav2.3 |
| 2 | B (B) | Voltage-dependent L-type calcium channel subunit beta-1 | polymer | 598 | 65799.6 | 1 | UniProt (Q02641) Pfam (PF12052) Pfam (PF00625) | Homo sapiens (human) | CAB1,Calcium channel voltage-dependent subunit beta 1 |
| 3 | C (D) | Voltage-dependent calcium channel subunit alpha-2/delta-1 | polymer | 1103 | 124692.5 | 1 | UniProt (P54289) Pfam (PF00092) Pfam (PF08473) Pfam (PF08399) | Homo sapiens (human) | Voltage-gated calcium channel subunit alpha-2/delta-1 |
| 4 | D, E (E, C) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 5 | F (F) | beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G44266EX) | |||
| 6 | G, L, N, P, Q... (A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 9 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (65082) PubChem (45489984) PubChem (363416) PubChem (60078761) PubChem (500055) PubChem (73440805) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (99567469) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (13301926) PubChem (13301927) PubChem (124914595) PubChem (124914596) PubChem (155804219) PubChem (169132514) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 7 | H, I, M, O, X... (A) | HEXADECANE | non-polymer | 226.4 | 6 | Chemie (R16) PubChem (11006) | |||
| 8 | J, K (A) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 2 | Chemie (3PE) | |||
| 9 | U, Z (A, D) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) PubChem (271) | |||
| 10 | V (A) | [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate | non-polymer | 339.4 | 1 | Chemie (TOR) PubChem (16757856) PubChem (5514) PubChem (21252335) PubChem (40467244) PubChem (40467245) PubChem (40467246) PubChem (45357229) PubChem (56840897) PubChem (44309678) PubChem (58649031) PubChem (60060464) PubChem (71296901) PubChem (73265248) PubChem (5284627) PubChem (92144467) PubChem (92779111) PubChem (6850784) PubChem (97406011) PubChem (10664802) PubChem (124425856) PubChem (124436525) PubChem (13458469) | |||
| 11 | AA, BA, CA, DA, EA... (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 452548.0 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1759.6 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 9424.5 | |
| All* | Total formula weight | 463732.2 |
