7YG5
Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the topiramate-bound state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Voltage-dependent R-type calcium channel subunit alpha-1E | polymer | 2313 | 262056.0 | 1 | UniProt (Q15878) Pfam (PF00520) Pfam (PF16905) Pfam (PF08763) | Homo sapiens (human) | Brain calcium channel II,BII,Calcium channel,L type,alpha-1 polypeptide,isoform 6,Voltage-gated calcium channel subunit alpha Cav2.3 |
| 2 | B (B) | Voltage-dependent L-type calcium channel subunit beta-1 | polymer | 598 | 65799.6 | 1 | UniProt (Q02641) Pfam (PF12052) Pfam (PF00625) | Homo sapiens (human) | CAB1,Calcium channel voltage-dependent subunit beta 1 |
| 3 | C (D) | Voltage-dependent calcium channel subunit alpha-2/delta-1 | polymer | 1103 | 124692.5 | 1 | UniProt (P54289) Pfam (PF00092) Pfam (PF08473) Pfam (PF08399) | Homo sapiens (human) | Voltage-gated calcium channel subunit alpha-2/delta-1 |
| 4 | D, E (E, C) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 5 | F (F) | beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G44266EX) | |||
| 6 | G, L, N, P, Q... (A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 9 | Chemie (Y01) | |||
| 7 | H, I, M, O, X... (A) | HEXADECANE | non-polymer | 226.4 | 6 | Chemie (R16) | |||
| 8 | J, K (A) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 2 | Chemie (3PE) | |||
| 9 | U, Z (A, D) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 10 | V (A) | [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate | non-polymer | 339.4 | 1 | Chemie (TOR) | |||
| 11 | AA, BA, CA, DA, EA... (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 452548.0 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1759.6 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 9424.5 | |
| All* | Total formula weight | 463732.2 |
