8T4M

Closed human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL

Summary for 8T4M

Entry DOI	10.2210/pdb8t4m/pdb
Related	5U6P
EMDB information	41036 41040 41041
Descriptor	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE (2 entities in total)
Functional Keywords	ion channel, transport protein
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	396804.10
Authors	Burtscher, V.,Mount, J.,Cowgill, J.,Chang, Y.,Bickel, K.,Yuan, P.,Chanda, B. (deposition date: 2023-06-09, release date: 2024-06-12)
Primary citation	Burtscher, V.,Mount, J.,Cowgill, J.,Chang, Y.,Bickel, K.,Yuan, P.,Chanda, B. Structural Basis for Hyperpolarization-dependent Opening of the Human HCN1 Channel To Be Published,
Experimental method	ELECTRON MICROSCOPY (3.16 Å)

Structure validation