6V8E
 
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5K7V
 | | Computational Design of Self-Assembling Cyclic Protein Homooligomers | | 分子名称: | Designed protein HR00C3 | | 著者 | Sankaran, B, Zwart, P.H, Fallas, J.A, Pereira, J.H, Ueda, G, Baker, D. | | 登録日 | 2016-05-26 | | 公開日 | 2017-04-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.165 Å) | | 主引用文献 | Computational design of self-assembling cyclic protein homo-oligomers.
Nat Chem, 9, 2017
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5KBA
 | | Computational Design of Self-Assembling Cyclic Protein Homooligomers | | 分子名称: | Designed protein ANK1C2 | | 著者 | Sankaran, B, Zwart, P.H, Fallas, J.A, Pereira, J.H, Ueda, G, Baker, D. | | 登録日 | 2016-06-02 | | 公開日 | 2017-04-12 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | | 主引用文献 | Computational design of self-assembling cyclic protein homo-oligomers.
Nat Chem, 9, 2017
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6FES
 | | Crystal structure of novel repeat protein BRIC2 fused to DARPin D12 | | 分子名称: | 1,2-ETHANEDIOL, D12_BRIC2, a synthetic protein,D12_BRIC2, ... | | 著者 | ElGamacy, M, Coles, M, Ernst, P, Zhu, H, Hartmann, M.D, Plueckthun, A, Lupas, A. | | 登録日 | 2018-01-03 | | 公開日 | 2018-09-05 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture.
ACS Synth Biol, 7, 2018
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6FF6
 | | Crystal structure of novel repeat protein BRIC1 | | 分子名称: | BRIC1 | | 著者 | ElGamacy, M, Coles, M, Ernst, P, Zhu, H, Hartmann, M.D, Plueckthun, A, Lupas, A.N. | | 登録日 | 2018-01-03 | | 公開日 | 2018-09-05 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture.
ACS Synth Biol, 7, 2018
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6DMP
 | | De Novo Design of a Protein Heterodimer with Specificity Mediated by Hydrogen Bond Networks | | 分子名称: | Designed orthogonal protein DHD13_XAAA_A, Designed orthogonal protein DHD13_XAAA_B | | 著者 | Chen, Z, Flores-Solis, D, Sgourakis, N.G, Baker, D. | | 登録日 | 2018-06-05 | | 公開日 | 2018-12-19 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Programmable design of orthogonal protein heterodimers.
Nature, 565, 2019
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3VI2
 | | Crystal Structure Analysis of Plasmodium falciparum OMP Decarboxylase in complex with inhibitor HMOA | | 分子名称: | 4-(2-hydroxy-4-methoxyphenyl)-4-oxobutanoic acid, Orotidine 5'-phosphate decarboxylase, SODIUM ION | | 著者 | Takashima, Y, Mizohata, E, Krungkrai, S.R, Matsumura, H, Krungkrai, J, Horii, T, Inoue, T. | | 登録日 | 2011-09-16 | | 公開日 | 2012-08-01 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The in silico screening and X-ray structure analysis of the inhibitor complex of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase
J.Biochem., 152, 2012
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4GN0
 | | De novo phasing of a Hamp-complex using an improved Arcimboldo method | | 分子名称: | Hamp domain of AF1503, MAGNESIUM ION | | 著者 | Hulko, M, Ursinus, A, Bar, K, Martin, J, Zeth, K, Lupas, A.N. | | 登録日 | 2012-08-16 | | 公開日 | 2013-09-11 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Exploiting tertiary structure through local folds for crystallographic phasing.
Nat.Methods, 10, 2013
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6L0B
 | | Crystal structure of dihydroorotase in complex with fluorouracil from Saccharomyces cerevisiae | | 分子名称: | 5-FLUOROURACIL, Dihydroorotase, ZINC ION | | 著者 | Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. | | 登録日 | 2019-09-26 | | 公開日 | 2020-12-02 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil.
Biochem.Biophys.Res.Commun., 551, 2021
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6L0G
 | | Crystal structure of dihydroorotase in complex with malate at pH6 from Saccharomyces cerevisiae | | 分子名称: | (2S)-2-hydroxybutanedioic acid, Dihydroorotase, ZINC ION | | 著者 | Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. | | 登録日 | 2019-09-26 | | 公開日 | 2020-12-02 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.053 Å) | | 主引用文献 | Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil.
Biochem.Biophys.Res.Commun., 551, 2021
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4FX8
 | | Crystal structure of the mutant Q185A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP | | 分子名称: | 6-HYDROXYURIDINE-5'-PHOSPHATE, Orotidine 5'-phosphate decarboxylase, SULFATE ION | | 著者 | Fedorov, A.A, Fedorov, E.V, Desai, B, Gerlt, J.A, Almo, S.C. | | 登録日 | 2012-07-02 | | 公開日 | 2013-06-19 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.9411 Å) | | 主引用文献 | Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme.
Biochemistry, 51, 2012
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3DA8
 | | Crystal structure of PurN from Mycobacterium tuberculosis | | 分子名称: | BETA-MERCAPTOETHANOL, IODIDE ION, MAGNESIUM ION, ... | | 著者 | Zhang, Z, Squire, C.J, Baker, E.N. | | 登録日 | 2008-05-28 | | 公開日 | 2009-05-12 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery.
J.Mol.Biol., 389, 2009
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3DCJ
 | | Crystal structure of glycinamide formyltransferase (PurN) from Mycobacterium tuberculosis in complex with 5-methyl-5,6,7,8-tetrahydrofolic acid derivative | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, N-[4-({[(6S)-2-AMINO-4-HYDROXY-5-METHYL-5,6,7,8-TETRAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC ACID, ... | | 著者 | Zhang, Z, Squire, C.J, Baker, E.N. | | 登録日 | 2008-06-03 | | 公開日 | 2009-05-12 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery.
J.Mol.Biol., 389, 2009
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8VEI
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8VEJ
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6FBA
 | | Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum with bound inhibitor 2,3-naphthalenediol | | 分子名称: | Aspartate transcarbamoylase, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | 著者 | Lunev, S, Bosch, S.S, Batista, F.A, Wang, C, Wrenger, C, Groves, M.R. | | 登録日 | 2017-12-18 | | 公開日 | 2018-02-21 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Identification of a non-competitive inhibitor of Plasmodium falciparum aspartate transcarbamoylase.
Biochem. Biophys. Res. Commun., 497, 2018
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2GCQ
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4ZYY
 | | Human GAR transformylase in complex with GAR and (S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)butyl]thiophene-3-carbonyl}amino)pentanedioic acid (AGF118) | | 分子名称: | (S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)butyl]thiophene-3-carbonyl}amino)pentanedioic acid, GLYCINAMIDE RIBONUCLEOTIDE, Trifunctional purine biosynthetic protein adenosine-3 | | 著者 | Deis, S.M, Dann III, C.E. | | 登録日 | 2015-05-22 | | 公開日 | 2016-04-20 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry, 55, 2016
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2MDW
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4ZZ0
 | | Human GAR transformylase in complex with GAR and (S)-2-(8-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)octanamido)pentanedioic acid (AGF147) | | 分子名称: | (S)-2-(8-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)octanamido)pentanedioic acid, GLYCINAMIDE RIBONUCLEOTIDE, Trifunctional purine biosynthetic protein adenosine-3 | | 著者 | Deis, S.M, Dann III, C.E. | | 登録日 | 2015-05-22 | | 公開日 | 2016-04-20 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry, 55, 2016
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4ZYX
 | | Human GAR transformylase in complex with GAR and (S)-2-({4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)butyl]thiophene-2-carbonyl}amino)pentanedioic acid (AGF117) | | 分子名称: | GLYCINAMIDE RIBONUCLEOTIDE, N-({4-[4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]thiophen-2-yl}carbonyl)-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3 | | 著者 | Deis, S.M, Dann III, C.E. | | 登録日 | 2015-05-22 | | 公開日 | 2016-04-20 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry, 55, 2016
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4ZYV
 | | Human GAR transformylase in complex with GAR and N-({5-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]thiophen-2-yl}carbonyl)-L-glutamic acid (AGF71) | | 分子名称: | GLYCINAMIDE RIBONUCLEOTIDE, N-({5-[4-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]thiophen-2-yl}carbonyl)-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3 | | 著者 | Deis, S.M, Dann III, C.E. | | 登録日 | 2015-05-22 | | 公開日 | 2016-04-20 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.053 Å) | | 主引用文献 | Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry, 55, 2016
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4ZYU
 | | Human GAR transformylase in complex with GAR and N-{4-[4-(2-Amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)-butyl]benzoyl}-L-glutamic acid (AGF50) | | 分子名称: | GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[4-(2-amino-4-oxo-1,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]benzoyl}-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3 | | 著者 | Deis, S.M, Dann III, C.E. | | 登録日 | 2015-05-22 | | 公開日 | 2016-04-20 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry, 55, 2016
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2MDV
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7DPT
 | | Structural basis for ligand binding modes of CTP synthase | | 分子名称: | 6-DIAZENYL-5-OXO-L-NORLEUCINE, ADENOSINE-5'-DIPHOSPHATE, CTP synthase, ... | | 著者 | Liu, J.L, Zhou, X, Guo, C.J, Chang, C.C. | | 登録日 | 2020-12-21 | | 公開日 | 2021-09-15 | | 実験手法 | ELECTRON MICROSCOPY (2.48 Å) | | 主引用文献 | Structural basis for ligand binding modes of CTP synthase.
Proc.Natl.Acad.Sci.USA, 118, 2021
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