6FBA

Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum with bound inhibitor 2,3-naphthalenediol

Summary for 6FBA

• Entry DOI: 10.2210/pdb6fba/pdb
• Related: 5ILQ
• Descriptor: Aspartate transcarbamoylase, SULFATE ION, naphthalene-2,3-diol, ... (10 entities in total)
• Functional Keywords: falciparum malaria pyrimidine biosynthesis trimer hit inhibitor, transferase
• Biological source: Plasmodium falciparum (malaria parasite P. falciparum); More
• Total number of polymer chains: 3
• Total formula weight: 122700.87

Authors

Lunev, S.,Bosch, S.S.,Batista, F.A.,Wang, C.,Wrenger, C.,Groves, M.R. (deposition date: 2017-12-18, release date: 2018-02-21, Last modification date: 2024-01-17)

• Primary citation: Lunev, S.,Bosch, S.S.,Batista, F.A.,Wang, C.,Li, J.,Linzke, M.,Kruithof, P.,Chamoun, G.,Domling, A.S.S.,Wrenger, C.,Groves, M.R.; Identification of a non-competitive inhibitor of Plasmodium falciparum aspartate transcarbamoylase.; Biochem. Biophys. Res. Commun., 497:835-842, 2018; PubMed: 29476738; DOI: 10.1016/j.bbrc.2018.02.112

Experimental method

X-RAY DIFFRACTION (2 Å)