PDB: 17012 件ウェブページステータス検索Chemie searchBIRD

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4H9S	Complex structure 6 of DAXX/H3.3(sub7)/H4 分子名称: Death domain-associated protein 6, Histone H3.3, Histone H4, ... 著者 Elsasser, S.J, Huang, H, Lewis, P.W, Chin, J.W, Allis, D.C, Patel, D.J. 登録日 2012-09-24 公開日 2012-10-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 DAXX chaperone envelops an H3.3/H4 dimer dictating H3.3-specific read out To be Published
6DAC	Human CYP3A4 bound to an inhibitor 分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2S)-1-{[(2R)-1-oxo-3-phenyl-1-{[2-(pyridin-3-yl)ethyl]amino}propan-2-yl]sulfanyl}-3-phenylpropan-2-yl]carbamate 著者 Sevrioukova, I.F. 登録日 2018-05-01 公開日 2019-04-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structure-Activity Relationships of Rationally Designed Ritonavir Analogues: Impact of Side-Group Stereochemistry, Headgroup Spacing, and Backbone Composition on the Interaction with CYP3A4. Biochemistry, 58, 2019
4CQM	Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP 分子名称: 1,2-ETHANEDIOL, ACETATE ION, CARBONYL REDUCTASE FAMILY MEMBER 4, ... 著者 Venkatesan, R, SahTeli, S.K, Awoniyi, L.O, Jiang, G, Prus, P, Kastoniotis, A.J, Hiltunen, J.K, Wierenga, R.K, Chen, Z. 登録日 2014-02-19 公開日 2014-09-10 最終更新日 2014-09-17 実験手法 X-RAY DIFFRACTION (2.339 Å) 主引用文献 Insights Into Mitochondrial Fatty Acid Synthesis from the Structure of Heterotetrameric 3-Ketoacyl-Acp Reductase/3R-Hydroxyacyl-Coa Dehydrogenase. Nat.Commun., 5, 2014
5ZNF	ALTERNATING ZINC FINGERS IN THE HUMAN MALE ASSOCIATED PROTEIN ZFY: 2D NMR STRUCTURE OF AN EVEN FINGER AND IMPLICATIONS FOR "JUMPING-LINKER" DNA RECOGNITION 分子名称: ZINC FINGER, ZINC ION 著者 Kochoyan, M, Keutmann, H.T, Weiss, M.A. 登録日 1991-08-22 公開日 1994-01-31 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition. Biochemistry, 30, 1991
5Z9C	Solution NMR structures of BRD4 first bromodomain with small compound MMQO 分子名称: 8-methoxy-6-methylquinolin-4(1H)-one, Bromodomain-containing protein 4 著者 Zeng, L, Zhou, M.-M. 登録日 2018-02-02 公開日 2018-02-14 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other "Shock" Drugs. J. Virol., 92, 2018
5CVO	WDR48:USP46~ubiquitin ternary complex 分子名称: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, WD repeat-containing protein 48, ... 著者 Harris, S.F, Yin, J. 登録日 2015-07-27 公開日 2015-10-07 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.885 Å) 主引用文献 Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46. Structure, 23, 2015
5WUA	Structure of a Pancreatic ATP-sensitive Potassium Channel 分子名称: ATP-sensitive inward rectifier potassium channel 11,superfolder GFP, SUR1 著者 Li, N, Wu, J.-X, Chen, L, Gao, N. 登録日 2016-12-16 公開日 2017-01-25 実験手法 ELECTRON MICROSCOPY (5.6 Å) 主引用文献 Structure of a Pancreatic ATP-Sensitive Potassium Channel Cell, 168, 2017
4H9P	Complex structure 3 of DAXX/H3.3(sub5,G90A)/H4 分子名称: Death domain-associated protein 6, Histone H3.3, Histone H4, ... 著者 Elsasser, S.J, Huang, H, Lewis, P.W, Chin, J.W, Allis, D.C, Patel, D.J. 登録日 2012-09-24 公開日 2012-10-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.198 Å) 主引用文献 DAXX chaperone envelops an H3.3/H4 dimer dictating H3.3-specific read out To be Published
6H7U	Crystal structure of a POT family transporter in complex with 5-aminolevulinic acid 分子名称: 5-azanyl-4-oxidanylidene-pentanoic acid, Peptide ABC transporter permease 著者 Minhas, G.S, Newstead, S. 登録日 2018-07-31 公開日 2018-12-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis for prodrug recognition by the SLC15 family of proton-coupled peptide transporters. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
5WCG	SET and MYND Domain Containing protein 2 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DIMETHYL SULFOXIDE, N-lysine methyltransferase SMYD2, ... 著者 Dong, A, Zeng, H, Walker, J.R, Hutch, A, Seitova, A, Tatlock, J, Kumpf, R, Owen, A, Taylor, A, Casimiro-Garcia, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) 登録日 2017-06-30 公開日 2017-08-02 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 The crystal structure of SMYD2 in complex with compound MTF003 to be published
6CCR	Selenomethionyl derivative of a GID4 fragment 分子名称: Glucose-induced degradation protein 4 homolog, UNKNOWN ATOM OR ION 著者 Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2018-02-07 公開日 2018-04-04 最終更新日 2018-04-25 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway. Nat. Chem. Biol., 14, 2018
5WES	Crystal Structure H2-Dd with disulfide-linked 5mer peptide 分子名称: Beta-2-microglobulin, GLYCINE, H-2 class I histocompatibility antigen, ... 著者 Jiang, J.S, Natarajan, K, Boyd, L.F, Margulies, D.H. 登録日 2017-07-10 公開日 2017-10-18 最終更新日 2017-12-13 実験手法 X-RAY DIFFRACTION (2.706 Å) 主引用文献 Crystal structure of a TAPBPR-MHC I complex reveals the mechanism of peptide editing in antigen presentation. Science, 358, 2017
4H7Y	Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1 分子名称: Dual specificity protein kinase TTK 著者 Bolanos-Garcia, V.M, Chirgadze, D.Y, Blundell, T.L. 登録日 2012-09-21 公開日 2012-12-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint). Biochem.J., 448, 2012
5WHD	Crystal structure of KRas G12V/D38P, bound to GDP 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE 著者 Shim, S.Y, McGee, J.H, Lee, S.-J, Verdine, G.L. 登録日 2017-07-16 公開日 2018-01-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.641 Å) 主引用文献 Exceptionally high-affinity Ras binders that remodel its effector domain. J. Biol. Chem., 293, 2018
5WLW	Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine Loop within ISCU1 active site, coordinating Zn ion. Complexed with human ISD11 and E. coli ACP1 at 3.3A. 分子名称: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ... 著者 Boniecki, M.T, Cygler, M. 登録日 2017-07-27 公開日 2017-11-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.317 Å) 主引用文献 Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. Nat Commun, 8, 2017
6AOZ	Crystal structure of human FLASH N-terminal domain C54S/C83A (Crystal form 1) 分子名称: 1,2-ETHANEDIOL, CASP8-associated protein 2 著者 Aik, W.S, Tong, L. 登録日 2017-08-16 公開日 2017-11-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing. PLoS ONE, 12, 2017
6ASA	KRAS mutant-D33E in GDP-bound 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Lu, J, Westover, K. 登録日 2017-08-24 公開日 2018-01-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.545 Å) 主引用文献 KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation. Biochemistry, 57, 2018
4MFU	Crystal structure of human CTNNBL1(residues 77~563) 分子名称: Beta-catenin-like protein 1 著者 Ahn, J.W, Kim, S, Kim, K.J. 登録日 2013-08-28 公開日 2014-03-12 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.744 Å) 主引用文献 Structural insights into the novel ARM-repeat protein CTNNBL1 and its association with the hPrp19-CDC5L complex Acta Crystallogr.,Sect.D, 70, 2014
6ASE	KRAS mutant-A59G in GDP-bound 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Westover, K, Lu, J. 登録日 2017-08-24 公開日 2018-01-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.554 Å) 主引用文献 KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation. Biochemistry, 57, 2018
5DV7	Crystal Structure of NF90 tandem dsRBDs with dsRNA 分子名称: Interleukin enhancer-binding factor 3, RNA (5'-R(*CP*CP*AP*GP*CP*AP*UP*UP*AP*UP*GP*AP*AP*AP*GP*UP*GP*A)-3'), RNA (5'-R(*UP*CP*AP*CP*UP*UP*UP*CP*AP*UP*AP*AP*UP*GP*CP*UP*GP*G)-3') 著者 Jayachandran, U, Grey, H, Cook, A.G. 登録日 2015-09-21 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Nuclear factor 90 uses an ADAR2-like binding mode to recognize specific bases in dsRNA. Nucleic Acids Res., 44, 2016
5WZX	Structural basis for a pentacyclic oleanane-type triterpenoid as a ligand of FXR 分子名称: (4aR,6aR,6aS,6bS,8aS,9R,12aR,14bR)-2,2,6a,6b,9,12a-hexamethyl-10-oxidanylidene-1,3,4,5,6,6a,7,8,8a,9,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid, (R,R)-2,3-BUTANEDIOL, Bile acid receptor, ... 著者 Lu, Y, Li, Y. 登録日 2017-01-19 公開日 2018-01-03 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Identification of an Oleanane-Type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity Mol. Pharmacol., 93, 2018
5E8N	The structure of the TEIPP associated Trh4 peptide in complex with H-2D(b) 分子名称: Beta-2-microglobulin, Ceramide synthase 5, GLYCEROL, ... 著者 Hafstrand, I, Doorduijn, E, Duru, A.D, Buratto, J, Oliveira, C.C, Sandalova, T, van Hall, T, Achour, A. 登録日 2015-10-14 公開日 2016-02-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer. J Immunol., 196, 2016
6GYJ	Mouse thymidylate synthase crystal soaked in phenolphthalein 分子名称: 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one, DIMETHYL SULFOXIDE, SULFATE ION, ... 著者 Maj, P, Jarmula, A, Wilk, P, Weiss, M.S, Rode, W. 登録日 2018-06-30 公開日 2019-08-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Thymidylate synthase fragment screening To be published
6GZ9	Crystal structure of a POT family transporter in complex with prodrug valacyclovir 分子名称: 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl L-valinate, Peptide ABC transporter permease 著者 Minhas, G.S, Newstead, S. 登録日 2018-07-03 公開日 2018-12-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural basis for prodrug recognition by the SLC15 family of proton-coupled peptide transporters. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
5E9Y	Crystal Structure of BAZ2B bromodomain in complex with MPD 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Bromodomain adjacent to zinc finger domain protein 2B 著者 Lolli, G, Caflisch, A. 登録日 2015-10-15 公開日 2016-03-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 High-Throughput Fragment Docking into the BAZ2B Bromodomain: Efficient in Silico Screening for X-Ray Crystallography. Acs Chem.Biol., 11, 2016

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