5WES

Crystal Structure H2-Dd with disulfide-linked 5mer peptide

Summary for 5WES

• Entry DOI: 10.2210/pdb5wes/pdb
• Descriptor: H-2 class I histocompatibility antigen, D-D alpha chain, Beta-2-microglobulin, Surface protein gp120, ... (5 entities in total)
• Functional Keywords: antigen presentation, peptide editing, major histompatibility complex class i, mhc-i, tapbpr, h2-dd, h-2dd, tapasin, peptide loading complex, plc, immune response, immune system
• Biological source: Mus musculus (Mouse); More
• Cellular location: Membrane; Single-pass type I membrane protein: P01900; Secreted: P01887; Surface protein gp120: Virion membrane ; Peripheral membrane protein . Transmembrane protein gp41: Virion membrane ; Single-pass type I membrane protein : P03377
• Total number of polymer chains: 3
• Total formula weight: 44506.93

Authors

Jiang, J.S.,Natarajan, K.,Boyd, L.F.,Margulies, D.H. (deposition date: 2017-07-10, release date: 2017-10-18, Last modification date: 2017-12-13)

• Primary citation: Jiang, J.,Natarajan, K.,Boyd, L.F.,Morozov, G.I.,Mage, M.G.,Margulies, D.H.; Crystal structure of a TAPBPR-MHC I complex reveals the mechanism of peptide editing in antigen presentation.; Science, 358:1064-1068, 2017; PubMed: 29025991; DOI: 10.1126/science.aao5154

Experimental method

X-RAY DIFFRACTION (2.706 Å)