4CQM
Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP
Summary for 4CQM
Entry DOI | 10.2210/pdb4cqm/pdb |
Related | 4CQL |
Descriptor | ESTRADIOL 17-BETA-DEHYDROGENASE 8, CARBONYL REDUCTASE FAMILY MEMBER 4, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (8 entities in total) |
Functional Keywords | oxidoreductase, kar, ketoacyl reductase, 3-ketoacyl-acp reductase, ke6, hsd8, 17-beta hydroxysteroid dehydrogenase, hsd17b8, 3r-hydroxyacyl-coa dehydrogenase, cbr4, carbobyl reductase type4, nad, nadh, nadp, nadph, hetero tetramer |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Mitochondrion matrix: Q92506 Q8N4T8 Q92506 |
Total number of polymer chains | 16 |
Total formula weight | 439364.52 |
Authors | Venkatesan, R.,SahTeli, S.K.,Awoniyi, L.O.,Jiang, G.,Prus, P.,Kastoniotis, A.J.,Hiltunen, J.K.,Wierenga, R.K.,Chen, Z. (deposition date: 2014-02-19, release date: 2014-09-10, Last modification date: 2014-09-17) |
Primary citation | Venkatesan, R.,Sah-Teli, S.K.,Awoniyi, L.O.,Jiang, G.,Prus, P.,Kastaniotis, A.J.,Hiltunen, J.K.,Wierenga, R.K.,Chen, Z. Insights Into Mitochondrial Fatty Acid Synthesis from the Structure of Heterotetrameric 3-Ketoacyl-Acp Reductase/3R-Hydroxyacyl-Coa Dehydrogenase. Nat.Commun., 5:4805-, 2014 Cited by PubMed: 25203508DOI: 10.1038/NCOMMS5805 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.339 Å) |
Structure validation
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