4CQM

Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP

Summary for 4CQM
Related4CQL
DescriptorESTRADIOL 17-BETA-DEHYDROGENASE 8, CARBONYL REDUCTASE FAMILY MEMBER 4, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (8 entities in total)
Functional Keywordsoxidoreductase, kar, ketoacyl reductase, 3-ketoacyl-acp reductase, ke6, hsd8, 17-beta hydroxysteroid dehydrogenase, hsd17b8, 3r-hydroxyacyl-coa dehydrogenase, cbr4, carbobyl reductase type4, nad, nadh, nadp, nadph, hetero tetramer
Biological sourceHOMO SAPIENS (HUMAN)
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Cellular locationMitochondrion matrix: Q92506 Q8N4T8 Q92506
Total number of polymer chains16
Total formula weight439364.52
Authors
Venkatesan, R.,SahTeli, S.K.,Awoniyi, L.O.,Jiang, G.,Prus, P.,Kastoniotis, A.J.,Hiltunen, J.K.,Wierenga, R.K.,Chen, Z. (deposition date: 2014-02-19, release date: 2014-09-10, Last modification date: 2014-09-17)
Primary citationAwoniyi, L.O.,Chen, Z.,Hiltunen, J.K.,Jiang, G.,Kastaniotis, A.J.,Prus, P.,Sah-Teli, S.K.,Venkatesan, R.,Wierenga, R.K.
Insights Into Mitochondrial Fatty Acid Synthesis from the Structure of Heterotetrameric 3-Ketoacyl-Acp Reductase/3R-Hydroxyacyl-Coa Dehydrogenase.
Nat.Commun., 5:4805-, 2014
PubMed: 25203508
DOI: 110.1038/NCOMMS5805
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.339 Å)
Structure validation
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PDB entries from 2021-06-09