4CQM

Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E, H, I, L...	ESTRADIOL 17-BETA-DEHYDROGENASE 8	polymer	261	26999.7	7	UniProt (Q92506) Pfam (PF13561) In PDB	HOMO SAPIENS (HUMAN)	17-BETA-HYDROXYSTEROID DEHYDROGENASE 8,17-BETA-HSD 8,3-OXOACYL-ACYL-CARRIER-PROTEIN REDUCTASE, PROTEIN KE6,KE-6,REALLY INTERESTING NEW GENE 2 PROTEIN, TESTOSTERONE 17-BETA-DEHYDROGENASE 8,3-KETOACYL REDUCTASE ALPHA SUBUNIT
2	B, C, F, G, J...	CARBONYL REDUCTASE FAMILY MEMBER 4	polymer	244	26298.5	8	UniProt (Q8N4T8) Pfam (PF13561) In PDB	HOMO SAPIENS (HUMAN)	3-OXOACYL-ACYL-CARRIER-PROTEIN REDUCTASE, QUINONE REDUCTASE CBR4,3-KETOACYL REDUCTASE BETA SUBUNIT
3	D	ESTRADIOL 17-BETA-DEHYDROGENASE 8	polymer	261	27041.8	1	UniProt (Q92506) Pfam (PF13561) In PDB	HOMO SAPIENS (HUMAN)	17-BETA-HYDROXYSTEROID DEHYDROGENASE 8,17-BETA-HSD 8,3-OXOACYL-ACYL-CARRIER-PROTEIN REDUCTASE, PROTEIN KE6,KE-6,REALLY INTERESTING NEW GENE 2 PROTEIN, TESTOSTERONE 17-BETA-DEHYDROGENASE 8,3-KETOACYL REDUCTASE ALPHA SUBUNIT
4	G, H, I, J, K...	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	16	Chemie (NAP)
5	I, M, A, E	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
6	F, I, L, M, P...	1,2-ETHANEDIOL	non-polymer		62.1	8	Chemie (EDO)
7	H, M, P	ACETATE ION	non-polymer		59.0	3	Chemie (ACT)
8		water	water		18.0	806	Chemie (HOH)

Sequence modifications

B, C, F, G, J, K, N, O: 1 - 237 (UniProt: Q8N4T8)

PDB	External Database	Details
Met -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	426428.0
Non-Polymers*	Number of molecules	31
	Total formula weight	12936.5
All*	Total formula weight	439364.5

*Water molecules are not included.