4CQM
Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E, H, I, L... (A, E, H, I, L...) | ESTRADIOL 17-BETA-DEHYDROGENASE 8 | polymer | 261 | 26999.7 | 7 | UniProt (Q92506) Pfam (PF13561) | HOMO SAPIENS (HUMAN) | 17-BETA-HYDROXYSTEROID DEHYDROGENASE 8,17-BETA-HSD 8,3-OXOACYL-ACYL-CARRIER-PROTEIN REDUCTASE, PROTEIN KE6,KE-6,REALLY INTERESTING NEW GENE 2 PROTEIN, TESTOSTERONE 17-BETA-DEHYDROGENASE 8,3-KETOACYL REDUCTASE ALPHA SUBUNIT |
| 2 | B, C, F, G, J... (B, C, F, G, J...) | CARBONYL REDUCTASE FAMILY MEMBER 4 | polymer | 244 | 26298.5 | 8 | UniProt (Q8N4T8) Pfam (PF13561) | HOMO SAPIENS (HUMAN) | 3-OXOACYL-ACYL-CARRIER-PROTEIN REDUCTASE, QUINONE REDUCTASE CBR4,3-KETOACYL REDUCTASE BETA SUBUNIT |
| 3 | D (D) | ESTRADIOL 17-BETA-DEHYDROGENASE 8 | polymer | 261 | 27041.8 | 1 | UniProt (Q92506) Pfam (PF13561) | HOMO SAPIENS (HUMAN) | 17-BETA-HYDROXYSTEROID DEHYDROGENASE 8,17-BETA-HSD 8,3-OXOACYL-ACYL-CARRIER-PROTEIN REDUCTASE, PROTEIN KE6,KE-6,REALLY INTERESTING NEW GENE 2 PROTEIN, TESTOSTERONE 17-BETA-DEHYDROGENASE 8,3-KETOACYL REDUCTASE ALPHA SUBUNIT |
| 4 | BA, CA, EA, IA, JA... (G, H, I, J, K...) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 16 | Chemie (NAP) | |||
| 5 | FA, NA, R, X (I, M, A, E) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 6 | AA, GA, HA, LA, OA... (F, I, L, M, P...) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 7 | DA, PA, UA (H, M, P) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 8 | AB, BB, CB, DB, EB... (F, G, H, I, J...) | water | water | 18.0 | 806 | Chemie (HOH) |
Sequence modifications
B, C, F, G, J, K, N, O: 1 - 237 (UniProt: Q8N4T8)
| PDB | External Database | Details |
|---|---|---|
| Met -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 426428.0 | |
| Non-Polymers* | Number of molecules | 31 |
| Total formula weight | 12936.5 | |
| All* | Total formula weight | 439364.5 |
