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4CQM

Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP

Functional Information from GO Data
ChainGOidnamespacecontents
A0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)] activity
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005740cellular_componentmitochondrial envelope
A0005759cellular_componentmitochondrial matrix
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006633biological_processfatty acid biosynthetic process
A0006694biological_processsteroid biosynthetic process
A0006703biological_processestrogen biosynthetic process
A0008209biological_processandrogen metabolic process
A0008210biological_processestrogen metabolic process
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
A0051290biological_processprotein heterotetramerization
A0070404molecular_functionNADH binding
A0106386molecular_function(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity
A1990204cellular_componentoxidoreductase complex
B0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
B0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B0005515molecular_functionprotein binding
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0006633biological_processfatty acid biosynthetic process
B0008753molecular_functionNADPH dehydrogenase (quinone) activity
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0044597biological_processdaunorubicin metabolic process
B0044598biological_processdoxorubicin metabolic process
B0048038molecular_functionquinone binding
B0051289biological_processprotein homotetramerization
B0051290biological_processprotein heterotetramerization
B0055114biological_processobsolete oxidation-reduction process
B0070402molecular_functionNADPH binding
B1990204cellular_componentoxidoreductase complex
C0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
C0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
C0005515molecular_functionprotein binding
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0006629biological_processlipid metabolic process
C0006631biological_processfatty acid metabolic process
C0006633biological_processfatty acid biosynthetic process
C0008753molecular_functionNADPH dehydrogenase (quinone) activity
C0016491molecular_functionoxidoreductase activity
C0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C0044597biological_processdaunorubicin metabolic process
C0044598biological_processdoxorubicin metabolic process
C0048038molecular_functionquinone binding
C0051289biological_processprotein homotetramerization
C0051290biological_processprotein heterotetramerization
C0055114biological_processobsolete oxidation-reduction process
C0070402molecular_functionNADPH binding
C1990204cellular_componentoxidoreductase complex
D0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)] activity
D0005515molecular_functionprotein binding
D0005739cellular_componentmitochondrion
D0005740cellular_componentmitochondrial envelope
D0005759cellular_componentmitochondrial matrix
D0005886cellular_componentplasma membrane
D0006629biological_processlipid metabolic process
D0006631biological_processfatty acid metabolic process
D0006633biological_processfatty acid biosynthetic process
D0006694biological_processsteroid biosynthetic process
D0006703biological_processestrogen biosynthetic process
D0008209biological_processandrogen metabolic process
D0008210biological_processestrogen metabolic process
D0016020cellular_componentmembrane
D0016491molecular_functionoxidoreductase activity
D0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
D0051290biological_processprotein heterotetramerization
D0070404molecular_functionNADH binding
D0106386molecular_function(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity
D1990204cellular_componentoxidoreductase complex
E0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)] activity
E0005515molecular_functionprotein binding
E0005739cellular_componentmitochondrion
E0005740cellular_componentmitochondrial envelope
E0005759cellular_componentmitochondrial matrix
E0005886cellular_componentplasma membrane
E0006629biological_processlipid metabolic process
E0006631biological_processfatty acid metabolic process
E0006633biological_processfatty acid biosynthetic process
E0006694biological_processsteroid biosynthetic process
E0006703biological_processestrogen biosynthetic process
E0008209biological_processandrogen metabolic process
E0008210biological_processestrogen metabolic process
E0016020cellular_componentmembrane
E0016491molecular_functionoxidoreductase activity
E0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
E0051290biological_processprotein heterotetramerization
E0070404molecular_functionNADH binding
E0106386molecular_function(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity
E1990204cellular_componentoxidoreductase complex
F0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
F0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
F0005515molecular_functionprotein binding
F0005739cellular_componentmitochondrion
F0005759cellular_componentmitochondrial matrix
F0006629biological_processlipid metabolic process
F0006631biological_processfatty acid metabolic process
F0006633biological_processfatty acid biosynthetic process
F0008753molecular_functionNADPH dehydrogenase (quinone) activity
F0016491molecular_functionoxidoreductase activity
F0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F0044597biological_processdaunorubicin metabolic process
F0044598biological_processdoxorubicin metabolic process
F0048038molecular_functionquinone binding
F0051289biological_processprotein homotetramerization
F0051290biological_processprotein heterotetramerization
F0055114biological_processobsolete oxidation-reduction process
F0070402molecular_functionNADPH binding
F1990204cellular_componentoxidoreductase complex
G0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
G0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
G0005515molecular_functionprotein binding
G0005739cellular_componentmitochondrion
G0005759cellular_componentmitochondrial matrix
G0006629biological_processlipid metabolic process
G0006631biological_processfatty acid metabolic process
G0006633biological_processfatty acid biosynthetic process
G0008753molecular_functionNADPH dehydrogenase (quinone) activity
G0016491molecular_functionoxidoreductase activity
G0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G0044597biological_processdaunorubicin metabolic process
G0044598biological_processdoxorubicin metabolic process
G0048038molecular_functionquinone binding
G0051289biological_processprotein homotetramerization
G0051290biological_processprotein heterotetramerization
G0055114biological_processobsolete oxidation-reduction process
G0070402molecular_functionNADPH binding
G1990204cellular_componentoxidoreductase complex
H0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)] activity
H0005515molecular_functionprotein binding
H0005739cellular_componentmitochondrion
H0005740cellular_componentmitochondrial envelope
H0005759cellular_componentmitochondrial matrix
H0005886cellular_componentplasma membrane
H0006629biological_processlipid metabolic process
H0006631biological_processfatty acid metabolic process
H0006633biological_processfatty acid biosynthetic process
H0006694biological_processsteroid biosynthetic process
H0006703biological_processestrogen biosynthetic process
H0008209biological_processandrogen metabolic process
H0008210biological_processestrogen metabolic process
H0016020cellular_componentmembrane
H0016491molecular_functionoxidoreductase activity
H0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
H0051290biological_processprotein heterotetramerization
H0070404molecular_functionNADH binding
H0106386molecular_function(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity
H1990204cellular_componentoxidoreductase complex
I0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)] activity
I0005515molecular_functionprotein binding
I0005739cellular_componentmitochondrion
I0005740cellular_componentmitochondrial envelope
I0005759cellular_componentmitochondrial matrix
I0005886cellular_componentplasma membrane
I0006629biological_processlipid metabolic process
I0006631biological_processfatty acid metabolic process
I0006633biological_processfatty acid biosynthetic process
I0006694biological_processsteroid biosynthetic process
I0006703biological_processestrogen biosynthetic process
I0008209biological_processandrogen metabolic process
I0008210biological_processestrogen metabolic process
I0016020cellular_componentmembrane
I0016491molecular_functionoxidoreductase activity
I0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
I0051290biological_processprotein heterotetramerization
I0070404molecular_functionNADH binding
I0106386molecular_function(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity
I1990204cellular_componentoxidoreductase complex
J0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
J0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
J0005515molecular_functionprotein binding
J0005739cellular_componentmitochondrion
J0005759cellular_componentmitochondrial matrix
J0006629biological_processlipid metabolic process
J0006631biological_processfatty acid metabolic process
J0006633biological_processfatty acid biosynthetic process
J0008753molecular_functionNADPH dehydrogenase (quinone) activity
J0016491molecular_functionoxidoreductase activity
J0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
J0044597biological_processdaunorubicin metabolic process
J0044598biological_processdoxorubicin metabolic process
J0048038molecular_functionquinone binding
J0051289biological_processprotein homotetramerization
J0051290biological_processprotein heterotetramerization
J0055114biological_processobsolete oxidation-reduction process
J0070402molecular_functionNADPH binding
J1990204cellular_componentoxidoreductase complex
K0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
K0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
K0005515molecular_functionprotein binding
K0005739cellular_componentmitochondrion
K0005759cellular_componentmitochondrial matrix
K0006629biological_processlipid metabolic process
K0006631biological_processfatty acid metabolic process
K0006633biological_processfatty acid biosynthetic process
K0008753molecular_functionNADPH dehydrogenase (quinone) activity
K0016491molecular_functionoxidoreductase activity
K0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
K0044597biological_processdaunorubicin metabolic process
K0044598biological_processdoxorubicin metabolic process
K0048038molecular_functionquinone binding
K0051289biological_processprotein homotetramerization
K0051290biological_processprotein heterotetramerization
K0055114biological_processobsolete oxidation-reduction process
K0070402molecular_functionNADPH binding
K1990204cellular_componentoxidoreductase complex
L0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)] activity
L0005515molecular_functionprotein binding
L0005739cellular_componentmitochondrion
L0005740cellular_componentmitochondrial envelope
L0005759cellular_componentmitochondrial matrix
L0005886cellular_componentplasma membrane
L0006629biological_processlipid metabolic process
L0006631biological_processfatty acid metabolic process
L0006633biological_processfatty acid biosynthetic process
L0006694biological_processsteroid biosynthetic process
L0006703biological_processestrogen biosynthetic process
L0008209biological_processandrogen metabolic process
L0008210biological_processestrogen metabolic process
L0016020cellular_componentmembrane
L0016491molecular_functionoxidoreductase activity
L0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
L0051290biological_processprotein heterotetramerization
L0070404molecular_functionNADH binding
L0106386molecular_function(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity
L1990204cellular_componentoxidoreductase complex
M0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)] activity
M0005515molecular_functionprotein binding
M0005739cellular_componentmitochondrion
M0005740cellular_componentmitochondrial envelope
M0005759cellular_componentmitochondrial matrix
M0005886cellular_componentplasma membrane
M0006629biological_processlipid metabolic process
M0006631biological_processfatty acid metabolic process
M0006633biological_processfatty acid biosynthetic process
M0006694biological_processsteroid biosynthetic process
M0006703biological_processestrogen biosynthetic process
M0008209biological_processandrogen metabolic process
M0008210biological_processestrogen metabolic process
M0016020cellular_componentmembrane
M0016491molecular_functionoxidoreductase activity
M0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
M0051290biological_processprotein heterotetramerization
M0070404molecular_functionNADH binding
M0106386molecular_function(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity
M1990204cellular_componentoxidoreductase complex
N0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
N0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
N0005515molecular_functionprotein binding
N0005739cellular_componentmitochondrion
N0005759cellular_componentmitochondrial matrix
N0006629biological_processlipid metabolic process
N0006631biological_processfatty acid metabolic process
N0006633biological_processfatty acid biosynthetic process
N0008753molecular_functionNADPH dehydrogenase (quinone) activity
N0016491molecular_functionoxidoreductase activity
N0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
N0044597biological_processdaunorubicin metabolic process
N0044598biological_processdoxorubicin metabolic process
N0048038molecular_functionquinone binding
N0051289biological_processprotein homotetramerization
N0051290biological_processprotein heterotetramerization
N0055114biological_processobsolete oxidation-reduction process
N0070402molecular_functionNADPH binding
N1990204cellular_componentoxidoreductase complex
O0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
O0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
O0005515molecular_functionprotein binding
O0005739cellular_componentmitochondrion
O0005759cellular_componentmitochondrial matrix
O0006629biological_processlipid metabolic process
O0006631biological_processfatty acid metabolic process
O0006633biological_processfatty acid biosynthetic process
O0008753molecular_functionNADPH dehydrogenase (quinone) activity
O0016491molecular_functionoxidoreductase activity
O0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
O0044597biological_processdaunorubicin metabolic process
O0044598biological_processdoxorubicin metabolic process
O0048038molecular_functionquinone binding
O0051289biological_processprotein homotetramerization
O0051290biological_processprotein heterotetramerization
O0055114biological_processobsolete oxidation-reduction process
O0070402molecular_functionNADPH binding
O1990204cellular_componentoxidoreductase complex
P0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)] activity
P0005515molecular_functionprotein binding
P0005739cellular_componentmitochondrion
P0005740cellular_componentmitochondrial envelope
P0005759cellular_componentmitochondrial matrix
P0005886cellular_componentplasma membrane
P0006629biological_processlipid metabolic process
P0006631biological_processfatty acid metabolic process
P0006633biological_processfatty acid biosynthetic process
P0006694biological_processsteroid biosynthetic process
P0006703biological_processestrogen biosynthetic process
P0008209biological_processandrogen metabolic process
P0008210biological_processestrogen metabolic process
P0016020cellular_componentmembrane
P0016491molecular_functionoxidoreductase activity
P0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
P0051290biological_processprotein heterotetramerization
P0070404molecular_functionNADH binding
P0106386molecular_function(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity
P1990204cellular_componentoxidoreductase complex
Functional Information from PDB Data
site_idAC1
Number of Residues29
DetailsBINDING SITE FOR RESIDUE NAP A 301
ChainResidue
AGLY18
ACYS103
AALA104
AGLY105
AILE106
AVAL126
AILE154
ASER155
ASER156
ATYR169
ALYS173
ASER21
APRO199
AGLY200
APHE201
AILE202
ATHR204
APRO205
AMET206
ATHR207
AHOH2002
AHOH2015
AGLY22
AILE23
AASP42
ALEU43
AALA74
AASP75
AVAL76

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 401
ChainResidue
AGLY159
AILE177
AGLN181
AHOH2033
DGLY159
DLYS160
DILE177

site_idAC3
Number of Residues25
DetailsBINDING SITE FOR RESIDUE NAP B 301
ChainResidue
BGLY9
BSER11
BARG12
BGLY13
BILE14
BALA33
BARG34
BASN35
BCYS55
BASP56
BVAL57
BALA83
BALA84
BGLY85
BILE86
BTHR106
BVAL133
BGLY134
BTYR148
BLYS152
BPRO178
BHOH2004
BHOH2005
BHOH2016
BHOH2032

site_idAC4
Number of Residues16
DetailsBINDING SITE FOR RESIDUE NAP C 301
ChainResidue
CGLY9
CSER11
CARG12
CGLY13
CILE14
CALA33
CARG34
CASN35
CCYS55
CASP56
CVAL57
CALA83
CALA84
CGLY85
CILE86
CTHR106

site_idAC5
Number of Residues27
DetailsBINDING SITE FOR RESIDUE NAP D 301
ChainResidue
DTHR204
DPRO205
DMET206
DTHR207
DHOH2004
DGLY18
DSER21
DGLY22
DILE23
DASP42
DLEU43
DALA74
DASP75
DVAL76
DCYS103
DALA104
DGLY105
DILE106
DVAL126
DILE154
DSER155
DOAS156
DTYR169
DLYS173
DPRO199
DGLY200
DILE202

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO D 401
ChainResidue
DTHR207
DGLN208
DVAL210
DVAL215

site_idAC7
Number of Residues30
DetailsBINDING SITE FOR RESIDUE NAP E 301
ChainResidue
BARG76
BHOH2013
EGLY18
ESER21
EGLY22
EILE23
EASP42
ELEU43
EALA74
EASP75
EVAL76
ECYS103
EALA104
EGLY105
EILE106
EVAL126
EILE154
ESER155
ESER156
ETYR169
ELYS173
EPRO199
EGLY200
EILE202
ETHR204
EPRO205
EMET206
ETHR207
EHOH2005
EHOH2021

site_idAC8
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL E 401
ChainResidue
EGLY159
ELYS160
EILE177
EHOH2043
HGLY159
HALA174
HILE177
HGLN181

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO E 402
ChainResidue
BARG28
ETHR207
EGLN208
EVAL210
EGLN212

site_idBC1
Number of Residues29
DetailsBINDING SITE FOR RESIDUE NAP F 301
ChainResidue
FGLY9
FSER11
FARG12
FGLY13
FILE14
FALA33
FARG34
FASN35
FCYS55
FASP56
FVAL57
FALA83
FALA84
FGLY85
FVAL133
FGLY134
FSER135
FTYR148
FLYS152
FGLY179
FVAL181
FTHR183
FASP184
FMET185
FTHR186
FHOH2008
FHOH2016
FHOH2018
FHOH2030

site_idBC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO F 401
ChainResidue
EARG8
EPHE239
EHOH2002
FHIS211
FVAL214
FGLU218

site_idBC3
Number of Residues12
DetailsBINDING SITE FOR RESIDUE NAP G 301
ChainResidue
GGLY9
GSER11
GARG12
GALA33
GARG34
GASN35
GCYS55
GASP56
GVAL57
GALA84
GGLY85
GTHR106

site_idBC4
Number of Residues32
DetailsBINDING SITE FOR RESIDUE NAP H 301
ChainResidue
HGLY18
HSER21
HGLY22
HILE23
HASP42
HLEU43
HALA74
HASP75
HVAL76
HCYS103
HALA104
HGLY105
HVAL126
HILE154
HSER155
HSER156
HTYR169
HLYS173
HPRO199
HGLY200
HPHE201
HILE202
HTHR204
HPRO205
HMET206
HTHR207
HACT501
HHOH2003
HHOH2015
HHOH2030
HHOH2035
HHOH2036

site_idBC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT H 501
ChainResidue
HSER156
HVAL158
HTYR169
HPHE201
HNAP301

site_idBC6
Number of Residues32
DetailsBINDING SITE FOR RESIDUE NAP I 301
ChainResidue
IGLY18
ISER21
IGLY22
IILE23
IASP42
ILEU43
IALA74
IASP75
IVAL76
ICYS103
IALA104
IGLY105
IILE106
IVAL126
IILE154
ISER155
ISER156
ITYR169
ILYS173
IPRO199
IGLY200
IILE202
ITHR204
IPRO205
IMET206
ITHR207
IHOH2006
IHOH2057
IHOH2058
NARG76
NHOH2001
NHOH2023

site_idBC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL I 401
ChainResidue
IGLY159
IILE177
IGLN181
IHOH2032
LGLY159
LLYS160

site_idBC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO I 402
ChainResidue
ITHR207
IGLN208
IVAL210
IGLN212
NARG28

site_idBC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO I 403
ChainResidue
ISER77
ILYS129
IHOH2060

site_idCC1
Number of Residues27
DetailsBINDING SITE FOR RESIDUE NAP J 301
ChainResidue
BHOH2008
JGLY9
JSER11
JARG12
JGLY13
JILE14
JALA33
JARG34
JASN35
JCYS55
JASP56
JVAL57
JALA83
JALA84
JGLY85
JILE86
JTHR106
JVAL133
JGLY134
JSER135
JTYR148
JLYS152
JGLY179
JVAL181
JTHR183
JMET185
JTHR186

site_idCC2
Number of Residues20
DetailsBINDING SITE FOR RESIDUE NAP K 301
ChainResidue
KGLY9
KSER11
KARG12
KGLY13
KILE14
KALA33
KARG34
KASN35
KCYS55
KASP56
KVAL57
KALA83
KALA84
KGLY85
KTHR106
KVAL133
KTYR148
KLYS152
KHOH2002
KHOH2007

site_idCC3
Number of Residues28
DetailsBINDING SITE FOR RESIDUE NAP L 301
ChainResidue
LGLY18
LSER21
LGLY22
LILE23
LASP42
LLEU43
LALA74
LASP75
LVAL76
LCYS103
LGLY105
LILE106
LVAL126
LILE154
LSER155
LSER156
LTYR169
LLYS173
LPRO199
LGLY200
LILE202
LTHR204
LPRO205
LMET206
LTHR207
LHOH2007
LHOH2027
LHOH2055

site_idCC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO L 401
ChainResidue
CHIS61
LHIS114
LHOH2056

site_idCC5
Number of Residues32
DetailsBINDING SITE FOR RESIDUE NAP M 301
ChainResidue
JARG76
JHOH2020
JHOH2022
JHOH2032
MGLY18
MSER21
MGLY22
MILE23
MASP42
MLEU43
MALA74
MASP75
MVAL76
MCYS103
MGLY105
MILE106
MVAL126
MILE154
MSER155
MSER156
MTYR169
MLYS173
MPRO199
MGLY200
MILE202
MTHR204
MPRO205
MMET206
MTHR207
MACT501
MHOH2006
MHOH2040

site_idCC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL M 401
ChainResidue
MGLY159
MILE177
MHOH2064
PGLY159
PALA174
PILE177

site_idCC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO M 402
ChainResidue
JARG28
MTHR207
MGLN208
MVAL210
MGLN212
MVAL215
MHOH2093

site_idCC8
Number of Residues8
DetailsBINDING SITE FOR RESIDUE ACT M 501
ChainResidue
JHOH2003
MSER156
MVAL158
MTYR169
MGLY200
MPHE201
MNAP301
MHOH2063

site_idCC9
Number of Residues23
DetailsBINDING SITE FOR RESIDUE NAP N 301
ChainResidue
NGLY9
NSER11
NARG12
NILE14
NALA33
NARG34
NASN35
NCYS55
NASP56
NVAL57
NALA83
NALA84
NGLY85
NVAL133
NGLY134
NSER135
NTYR148
NLYS152
NVAL181
NHOH2007
NHOH2016
NHOH2029
NHOH2051

site_idDC1
Number of Residues22
DetailsBINDING SITE FOR RESIDUE NAP O 301
ChainResidue
OSER11
OARG12
OGLY13
OILE14
OALA33
OARG34
OASN35
OCYS55
OASP56
OVAL57
OALA83
OALA84
OGLY85
OILE86
OTHR106
OGLY134
OSER135
OTYR148
OVAL181
OTHR183
OHOH2001
OHOH2002

site_idDC2
Number of Residues27
DetailsBINDING SITE FOR RESIDUE NAP P 301
ChainResidue
PGLY18
PSER21
PILE23
PASP42
PLEU43
PALA74
PASP75
PVAL76
PCYS103
PGLY105
PILE106
PVAL126
PILE154
PSER155
PSER156
PTYR169
PLYS173
PPRO199
PGLY200
PILE202
PTHR204
PPRO205
PMET206
PTHR207
PACT501
PHOH2003
PHOH2052

site_idDC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO P 401
ChainResidue
PGLN208
PVAL210
PPRO211

site_idDC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT P 501
ChainResidue
PSER156
PVAL158
PTYR169
PPHE201
PNAP301

Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. SivglkgnsgQsvYSASKGGLvGFSrALA
ChainResidueDetails
BSER135-ALA163
ASER156-ALA184
DOAS156-ALA184

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001
ChainResidueDetails
DTYR169
CTYR148
FTYR148
GTYR148
JTYR148
KTYR148
NTYR148
OTYR148

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:25203508, ECO:0000269|Ref.12, ECO:0007744|PDB:2PD6, ECO:0007744|PDB:4CQL
ChainResidueDetails
DLEU15
CASP56
CALA83
CTYR148
CLYS152
CVAL181
FSER11
FARG34
FASP56
FALA83
FTYR148
DASP42
FLYS152
FVAL181
GSER11
GARG34
GASP56
GALA83
GTYR148
GLYS152
GVAL181
JSER11
DALA74
JARG34
JASP56
JALA83
JTYR148
JLYS152
JVAL181
KSER11
KARG34
KASP56
KALA83
DTYR169
KTYR148
KLYS152
KVAL181
NSER11
NARG34
NASP56
NALA83
NTYR148
NLYS152
NVAL181
BTYR148
OSER11
OARG34
OASP56
OALA83
OTYR148
OLYS152
OVAL181
BLYS152
BVAL181
CSER11
CARG34

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
DOAS156
CSER135
FSER135
GSER135
JSER135
KSER135
NSER135
OSER135

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|Ref.12, ECO:0007744|PDB:2PD6, ECO:0007744|PDB:4CQM
ChainResidueDetails
DILE202
CLYS169
FLYS169
GLYS169
JLYS169
KLYS169
NLYS169
OLYS169

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P50171
ChainResidueDetails
DSER60
CMET1
FMET1
GMET1
JMET1
KMET1
NMET1
OMET1

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P50171
ChainResidueDetails
DLYS160
GLYS40
GLYS96
GLYS195
JLYS40
JLYS96
JLYS195
KLYS40
KLYS96
KLYS195
NLYS40
DLYS173
NLYS96
NLYS195
OLYS40
OLYS96
OLYS195
BLYS195
CLYS40
CLYS96
CLYS195
FLYS40
FLYS96
FLYS195

217705

PDB entries from 2024-03-27

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