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5WLW

Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine Loop within ISCU1 active site, coordinating Zn ion. Complexed with human ISD11 and E. coli ACP1 at 3.3A.

Summary for 5WLW
Entry DOI10.2210/pdb5wlw/pdb
Related5WGB 5WKP
DescriptorCysteine desulfurase, mitochondrial, LYR motif-containing protein 4, Acyl carrier protein, ... (7 entities in total)
Functional Keywordshuman mitochondrial cysteine desulfurse lyr motif containing protein 4 iron-sulfur cluster scaffold protein iscu1 with zn in the active site acyl carrier protein 1 (e.coli), transferase
Biological sourceHomo sapiens (Human)
More
Cellular locationIsoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm: Q9Y697
Mitochondrion: Q9HD34
Cytoplasm : B7MJ81
Isoform 1: Mitochondrion . Isoform 2: Cytoplasm: Q9H1K1
Total number of polymer chains8
Total formula weight163100.69
Authors
Boniecki, M.T.,Cygler, M. (deposition date: 2017-07-27, release date: 2017-11-15, Last modification date: 2023-10-04)
Primary citationBoniecki, M.T.,Freibert, S.A.,Muhlenhoff, U.,Lill, R.,Cygler, M.
Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.
Nat Commun, 8:1287-1287, 2017
Cited by
PubMed: 29097656
DOI: 10.1038/s41467-017-01497-1
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.317 Å)
Structure validation

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