4H7Y
Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1
Summary for 4H7Y
Entry DOI | 10.2210/pdb4h7y/pdb |
Related | 4H7X |
Descriptor | Dual specificity protein kinase TTK (2 entities in total) |
Functional Keywords | mitotic checkpoint kinase, chromosome instability, cancer, tetratricopeptide repeat (tpr) motif, mitotic checkpoint, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 72748.22 |
Authors | Bolanos-Garcia, V.M.,Chirgadze, D.Y.,Blundell, T.L. (deposition date: 2012-09-21, release date: 2012-12-12, Last modification date: 2024-02-28) |
Primary citation | Thebault, P.,Chirgadze, D.Y.,Dou, Z.,Blundell, T.L.,Elowe, S.,Bolanos-Garcia, V.M. Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint). Biochem.J., 448:321-328, 2012 Cited by PubMed: 23067341DOI: 10.1042/BJ20121448 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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