5WZX

Structural basis for a pentacyclic oleanane-type triterpenoid as a ligand of FXR

Summary for 5WZX

• Entry DOI: 10.2210/pdb5wzx/pdb
• Descriptor: Bile acid receptor, SRC2-3 peptide from Nuclear receptor coactivator 2, (4aR,6aR,6aS,6bS,8aS,9R,12aR,14bR)-2,2,6a,6b,9,12a-hexamethyl-10-oxidanylidene-1,3,4,5,6,6a,7,8,8a,9,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid, ... (5 entities in total)
• Functional Keywords: fxr ligand, transcription
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1; Nucleus: Q15596
• Total number of polymer chains: 4
• Total formula weight: 57430.32

Authors

Lu, Y.,Li, Y. (deposition date: 2017-01-19, release date: 2018-01-03, Last modification date: 2023-11-22)

• Primary citation: Lu, Y.,Zheng, W.,Lin, S.,Guo, F.,Zhu, Y.,Wei, Y.,Liu, X.,Jin, S.,Jin, L.,Li, Y.; Identification of an Oleanane-Type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity; Mol. Pharmacol., 93:63-72, 2018; PubMed: 29162643; DOI: 10.1124/mol.117.109900

Experimental method

X-RAY DIFFRACTION (2.95 Å)