PDB: 1227 件ウェブページステータス検索Chemie searchBIRD

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8WC8	Cryo-EM structure of the ZH8651-bound hTAAR1-Gs complex 分子名称: 2-(4-bromophenyl)ethanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. 登録日 2023-09-11 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023
8WC6	Cryo-EM structure of the PEA-bound mTAAR1-Gs complex 分子名称: 2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. 登録日 2023-09-11 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023
8WC5	Cryo-EM structure of the TMA-bound mTAAR1-Gs complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. 登録日 2023-09-11 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023
8WCC	Cryo-EM structure of the CHA-bound mTAAR1 complex 分子名称: CYCLOHEXYLAMMONIUM ION, Trace amine-associated receptor 1 著者 Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. 登録日 2023-09-11 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023
8QOT	Structure of the mu opioid receptor bound to the antagonist nanobody NbE 分子名称: Anti-Fab Nanobody, Mu-type opioid receptor, NabFab HC, ... 著者 Yu, J, Kumar, A, Zhang, X, Martin, C, Raia, P, Manglik, A, Ballet, S, Boland, A, Stoeber, M. 登録日 2023-09-29 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural Basis of mu-Opioid Receptor-Targeting by a Nanobody Antagonist. Biorxiv, 2023
8XBI	Human GPR34 -Gi complex bound to M1, receptor focused 分子名称: (2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[3-[2-[(3-phenoxyphenyl)methoxy]phenyl]propanoyloxy]propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid, Probable G-protein coupled receptor 34 著者 Kawahara, R, Shihoya, W, Nureki, O. 登録日 2023-12-06 公開日 2023-12-27 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.06 Å) 主引用文献 Structural basis for lysophosphatidylserine recognition by GPR34. Nat Commun, 15, 2024
8XBH	Human GPR34 -Gi complex bound to M1 分子名称: (2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[3-[2-[(3-phenoxyphenyl)methoxy]phenyl]propanoyloxy]propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Kawahara, R, Shihoya, W, Nureki, O. 登録日 2023-12-06 公開日 2023-12-27 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (2.83 Å) 主引用文献 Structural basis for lysophosphatidylserine recognition by GPR34. Nat Commun, 15, 2024
8HJ1	GPR21(wt) and Gs complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Chen, B, Lin, X, Xu, F. 登録日 2022-11-22 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
8W8Q	Cryo-EM structure of the GPR101-Gs complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Sun, J.P, Gao, N, Yu, X, Wang, G.P, Yang, F, Wang, J.Y, Yang, Z, Guan, Y. 登録日 2023-09-04 公開日 2024-01-03 最終更新日 2024-04-10 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nat.Chem.Biol., 20, 2024
8W8S	Cryo-EM structure of the AA14-bound GPR101 complex 分子名称: 1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea, Probable G-protein coupled receptor 101 著者 Sun, J.P, Yu, X, Gao, N, Yang, F, Wang, J.Y, Yang, Z, Guan, Y, Wang, G.P. 登録日 2023-09-04 公開日 2024-01-03 最終更新日 2024-04-10 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nat.Chem.Biol., 20, 2024
8W8R	Cryo-EM structure of the AA-14-bound GPR101-Gs complex 分子名称: 1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Sun, J.P, Yu, X, Gao, N, Yang, F, Wang, J.Y, Yang, Z, Guan, Y, Wang, G.P. 登録日 2023-09-04 公開日 2024-01-03 最終更新日 2024-04-10 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nat.Chem.Biol., 20, 2024
8IJA	Cryo-EM structure of human HCAR2-Gi complex with niacin 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Pan, X, Fang, Y. 登録日 2023-02-26 公開日 2024-01-03 実験手法 ELECTRON MICROSCOPY (2.69 Å) 主引用文献 Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Discov, 9, 2023
8IJD	Cryo-EM structure of human HCAR2-Gi complex with MK-6892 分子名称: 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Pan, X, Fang, Y. 登録日 2023-02-27 公開日 2024-01-03 実験手法 ELECTRON MICROSCOPY (3.25 Å) 主引用文献 Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Discov, 9, 2023
8IJ3	Cryo-EM structure of human HCAR2-Gi complex without ligand (apo state) 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Pan, X, Fang, Y. 登録日 2023-02-24 公開日 2024-01-03 実験手法 ELECTRON MICROSCOPY (3.28 Å) 主引用文献 Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Discov, 9, 2023
8IJB	Cryo-EM structure of human HCAR2-Gi complex with acipimox 分子名称: 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Pan, X, Fang, Y. 登録日 2023-02-27 公開日 2024-01-03 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Discov, 9, 2023
8GCM	Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein 分子名称: (5S)-5-[(3R)-4,4-difluoro-3-hydroxy-4-phenylbutyl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-one, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Huang, S.M, Xiong, M.Y, Liu, L, Mu, J, Sheng, C, Sun, J. 登録日 2023-03-02 公開日 2024-01-03 最終更新日 2024-01-10 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
8GCP	Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein 分子名称: (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Huang, S.M, Xiong, M.Y, Liu, L, Mu, J, Sheng, C, Sun, J. 登録日 2023-03-02 公開日 2024-01-03 最終更新日 2024-01-10 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
8J6J	Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound with GSK256073 分子名称: 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X. 登録日 2023-04-26 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep, 42, 2023
8JGF	CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22 分子名称: BAM8-22, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Sun, J.P, Xu, H.E, Yang, F, Liu, Z.M, Guo, L.L, Zhang, Y.M, Fang, G.X, Tie, L, Zhuang, Y.M, Xue, C.Y. 登録日 2023-05-20 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commun, 14, 2023
8JGG	CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist BAM8-22 分子名称: BAM8-22, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Sun, J.P, Xu, H.E, Ynag, F, Liu, Z.M, Guo, L.L, Zhang, Y.M, Fang, G.X, Tie, L, Zhuang, Y.M, Xue, C.Y. 登録日 2023-05-20 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commun, 14, 2023
8JGB	CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist CNF-Tx2 分子名称: Conorfamide-Tx2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Sun, J.P, Xu, H.E, Yang, F, Liu, Z.M, Guo, L.L, Zhang, Y.M, Fang, G.X, Tie, L, Zhuang, Y.M, Xue, C.Y. 登録日 2023-05-20 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (2.84 Å) 主引用文献 Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commun, 14, 2023
8GDA	Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein 分子名称: (2S,5R)-5-[(1E,3S)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Shenming, H, Mengyao, X, Lei, L, Jiangqian, M, Sheng, C, Jinpeng, S. 登録日 2023-03-03 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
8GDB	Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein 分子名称: (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Shenming, H, Mengyao, X, Lei, L, Jianqiang, M, Jinpeng, S. 登録日 2023-03-03 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
8GDC	Cryo-EM Structure of the Prostaglandin E2 Receptor 3 Coupled to G Protein 分子名称: (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Shenming, H, Mengyao, X, Lei, L, Yang, D, Shiyi, G, Jinpeng, S. 登録日 2023-03-03 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
8GD9	Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein 分子名称: 4-({2-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]butyl}cyclopentyl]ethyl}sulfanyl)butanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Shenming, H, Mengyao, X, Lei, L, Yang, D, Sheng, C, Jinpeng, S. 登録日 2023-03-03 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023

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