8UQC
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![BU of 8uqc by Molmil](/molmil-images/mine/8uqc) | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization condition 2) | 分子名称: | E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, ZINC ION | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | 登録日 | 2023-10-23 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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7EJC
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![BU of 7ejc by Molmil](/molmil-images/mine/7ejc) | human RAD51 presynaptic complex | 分子名称: | 4-bromanyl-N-(4-bromophenyl)-3-[(phenylmethyl)sulfamoyl]benzamide, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA repair protein RAD51 homolog 1, ... | 著者 | Zhao, L.Y, Xu, J.F, Wang, H.W. | 登録日 | 2021-04-02 | 公開日 | 2022-04-06 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination. Nucleic Acids Res., 49, 2021
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3L11
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![BU of 3l11 by Molmil](/molmil-images/mine/3l11) | Crystal Structure of the Ring Domain of RNF168 | 分子名称: | E3 ubiquitin-protein ligase RNF168, MALONATE ION, ZINC ION | 著者 | Neculai, D, Yermekbayeva, L, Crombet, L, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2009-12-10 | 公開日 | 2010-01-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation. J.Biol.Chem., 287, 2012
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7F9A
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![BU of 7f9a by Molmil](/molmil-images/mine/7f9a) | Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L97 | 分子名称: | 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, ... | 著者 | Manickam, Y, Malhotra, N, Sharma, A. | 登録日 | 2021-07-04 | 公開日 | 2022-10-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | 主引用文献 | Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19, 2023
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7F9D
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![BU of 7f9d by Molmil](/molmil-images/mine/7f9d) | Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L96 | 分子名称: | 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, ... | 著者 | Manickam, Y, Malhotra, N, Sharma, A. | 登録日 | 2021-07-04 | 公開日 | 2022-10-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.497 Å) | 主引用文献 | Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19, 2023
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7F9B
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![BU of 7f9b by Molmil](/molmil-images/mine/7f9b) | Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L95 | 分子名称: | Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, CHLORIDE ION, ... | 著者 | Manickam, Y, Malhotra, N, Sharma, A. | 登録日 | 2021-07-04 | 公開日 | 2022-10-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.995 Å) | 主引用文献 | Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19, 2023
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7F9C
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![BU of 7f9c by Molmil](/molmil-images/mine/7f9c) | Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L96 | 分子名称: | 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, ... | 著者 | Malhotra, N, Manickam, Y, Sharma, A. | 登録日 | 2021-07-04 | 公開日 | 2022-07-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.196 Å) | 主引用文献 | Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19, 2023
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7F99
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![BU of 7f99 by Molmil](/molmil-images/mine/7f99) | Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L96 | 分子名称: | 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, ... | 著者 | Manickam, Y, Malhotra, N, Sharma, A. | 登録日 | 2021-07-04 | 公開日 | 2022-07-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.979 Å) | 主引用文献 | Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19, 2023
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4N9F
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![BU of 4n9f by Molmil](/molmil-images/mine/4n9f) | Crystal structure of the Vif-CBFbeta-CUL5-ElOB-ElOC pentameric complex | 分子名称: | Core-binding factor subunit beta, Cullin-5, Transcription elongation factor B polypeptide 1, ... | 著者 | Guo, Y.Y, Dong, L.Y, Huang, Z.W. | 登録日 | 2013-10-21 | 公開日 | 2014-01-08 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural basis for hijacking CBF-b and CUL5 E3 ligase complex by HIV-1 Vif Nature, 505, 2014
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8GYK
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![BU of 8gyk by Molmil](/molmil-images/mine/8gyk) | CryoEM structure of the RAD51_ADP filament | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA repair protein RAD51 homolog 1, MAGNESIUM ION | 著者 | Miki, Y, Luo, S.C, Ho, M.C. | 登録日 | 2022-09-22 | 公開日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | A RAD51-ADP double filament structure unveils the mechanism of filament dynamics in homologous recombination. Nat Commun, 14, 2023
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3H1D
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![BU of 3h1d by Molmil](/molmil-images/mine/3h1d) | Structure of the HUWE1 HECT Domain | 分子名称: | E3 ubiquitin-protein ligase HUWE1, SULFATE ION | 著者 | Partridge, J.R, Schwartz, T.U. | 登録日 | 2009-04-11 | 公開日 | 2009-12-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.892 Å) | 主引用文献 | A structural element within the HUWE1 HECT domain modulates self-ubiquitination and substrate ubiquitination activities. J.Biol.Chem., 285, 2010
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7KA0
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![BU of 7ka0 by Molmil](/molmil-images/mine/7ka0) | Crystal structure of the complex of M. tuberculosis PheRS with cognate precursor tRNA and phenylalanine | 分子名称: | ACETATE ION, GLYCEROL, MAGNESIUM ION, ... | 著者 | Chang, C, Michalska, K, Jedrzejczak, R, Wower, J, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2020-09-29 | 公開日 | 2021-05-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation. Nucleic Acids Res., 49, 2021
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7KAB
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![BU of 7kab by Molmil](/molmil-images/mine/7kab) | M. tuberculosis PheRS complex with cognate precursor tRNA and phenylalanine | 分子名称: | GLYCEROL, MAGNESIUM ION, PHENYLALANINE, ... | 著者 | Chang, C, Michalska, K, Jedrzejczak, R, Wower, J, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2020-09-30 | 公開日 | 2021-05-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation. Nucleic Acids Res., 49, 2021
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5V8F
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![BU of 5v8f by Molmil](/molmil-images/mine/5v8f) | Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 | 分子名称: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (39-MER), ... | 著者 | Yuan, Z, Riera, A, Bai, L, Sun, J, Spanos, C, Chen, Z.A, Barbon, M, Rappsilber, J, Stillman, B, Speck, C, Li, H. | 登録日 | 2017-03-21 | 公開日 | 2017-05-10 | 最終更新日 | 2020-04-22 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1. Nat. Struct. Mol. Biol., 24, 2017
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4GB0
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![BU of 4gb0 by Molmil](/molmil-images/mine/4gb0) | |
3VGO
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![BU of 3vgo by Molmil](/molmil-images/mine/3vgo) | |
5VF0
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![BU of 5vf0 by Molmil](/molmil-images/mine/5vf0) | |
8BGU
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![BU of 8bgu by Molmil](/molmil-images/mine/8bgu) | human MDM2-5S RNP | 分子名称: | 5S rRNA, 60S ribosomal protein L11, 60S ribosomal protein L5, ... | 著者 | Castillo, N, Thoms, M, Flemming, D, Hammaren, H.M, Buschauer, R, Ameismeier, M, Bassler, J, Beck, M, Beckmann, R, Hurt, E. | 登録日 | 2022-10-28 | 公開日 | 2023-06-14 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structure of nascent 5S RNPs at the crossroad between ribosome assembly and MDM2-p53 pathways. Nat.Struct.Mol.Biol., 30, 2023
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8P83
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![BU of 8p83 by Molmil](/molmil-images/mine/8p83) | Cryo-EM structure of full-length human UBR5 (homotetramer) | 分子名称: | E3 ubiquitin-protein ligase UBR5 | 著者 | Aguirre, J.D, Kater, L, Kempf, G, Cavadini, S, Thoma, N.H. | 登録日 | 2023-05-31 | 公開日 | 2023-06-14 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability. Mol.Cell, 83, 2023
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8P82
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![BU of 8p82 by Molmil](/molmil-images/mine/8p82) | Cryo-EM structure of dimeric UBR5 | 分子名称: | E3 ubiquitin-protein ligase UBR5, ZINC ION | 著者 | Aguirre, J.D, Kater, L, Kempf, G, Cavadini, S, Thoma, N.H. | 登録日 | 2023-05-31 | 公開日 | 2023-06-14 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability. Mol.Cell, 83, 2023
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6NOW
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![BU of 6now by Molmil](/molmil-images/mine/6now) | |
6NLY
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![BU of 6nly by Molmil](/molmil-images/mine/6nly) | |
6NLQ
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8WJL
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![BU of 8wjl by Molmil](/molmil-images/mine/8wjl) | Cryo-EM structure of 6-subunit Smc5/6 hinge region | 分子名称: | E3 SUMO-protein ligase MMS21, Structural maintenance of chromosomes protein 5, Structural maintenance of chromosomes protein 6 | 著者 | Li, Q, Zhang, J, Zhang, X, Cheng, T, Wang, Z, Jin, D, Chen, Z, Wang, L. | 登録日 | 2023-09-26 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (6.15 Å) | 主引用文献 | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat.Struct.Mol.Biol., 2024
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7C9A
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![BU of 7c9a by Molmil](/molmil-images/mine/7c9a) | Human RAD51 post-synaptic complexes mutant (V273P, D274G) | 分子名称: | CALCIUM ION, DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ... | 著者 | Chi, H.Y, Ho, M.C, Tsai, M.D, Luo, S.C, Yeh, H.Y. | 登録日 | 2020-06-05 | 公開日 | 2020-11-18 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures. Nat Commun, 12, 2021
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