7F9B
Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L95
Summary for 7F9B
Entry DOI | 10.2210/pdb7f9b/pdb |
Descriptor | Bifunctional glutamate/proline--tRNA ligase, ~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide, ZINC ION, ... (7 entities in total) |
Functional Keywords | protein translation, inhibitor, prs, atp pocket, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 116478.38 |
Authors | Manickam, Y.,Malhotra, N.,Sharma, A. (deposition date: 2021-07-04, release date: 2022-10-05, Last modification date: 2023-11-29) |
Primary citation | Yogavel, M.,Bougdour, A.,Mishra, S.,Malhotra, N.,Chhibber-Goel, J.,Bellini, V.,Harlos, K.,Laleu, B.,Hakimi, M.A.,Sharma, A. Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19:e1011124-e1011124, 2023 Cited by PubMed: 36854028DOI: 10.1371/journal.ppat.1011124 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.995 Å) |
Structure validation
Download full validation report