8UQC

Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization condition 2)

Summary for 8UQC

Entry DOI	10.2210/pdb8uqc/pdb
Descriptor	E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, ZINC ION (3 entities in total)
Functional Keywords	rnf168, ubch5c, histone h2a, histone h2b, chromatin, ubiquitin ligase, ubiquitin-conjugating enzyme, dna damage response, dna double-strand break repair, protein binding, protein binding-transferase complex, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	50171.14
Authors	Hu, Q.,Botuyan, M.V.,Mer, G. (deposition date: 2023-10-23, release date: 2024-01-17, Last modification date: 2024-03-20)
Primary citation	Hu, Q.,Zhao, D.,Cui, G.,Bhandari, J.,Thompson, J.R.,Botuyan, M.V.,Mer, G. Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84:839-853.e12, 2024 Cited by PubMed: 38242129 DOI: 10.1016/j.molcel.2023.12.036 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.61 Å)

Structure validation