PDB: 13258 件ウェブページステータス検索Chemie searchBIRD

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5FUC	Biophysical and cellular characterisation of a junctional epitope antibody that locks IL-6 and gp80 together in a stable complex: implications for new therapeutic strategies 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, INTERLEUKIN-6, INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, ... 著者 Adams, R, Griffin, R, Doyle, C, Ettorre, A. 登録日 2016-01-25 公開日 2017-01-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling. Sci Rep, 7, 2017
3FJK	Crystal structure of A66C mutant of Human acidic fibroblast growth factor 分子名称: FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION 著者 Blaber, M, Lee, J. 登録日 2008-12-14 公開日 2009-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine. J.Mol.Biol., 393, 2009
3KD0	Human thioredoxin C35S,C62S,C69S,C73S mutant showing cadmium chloride bound to the active site 分子名称: CADMIUM ION, CHLORIDE ION, Thioredoxin 著者 Hall, G, Emsley, J. 登録日 2009-10-22 公開日 2010-12-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The 1.7 A resolution crystal structure of a cadmium chloride complex with the active site of a mutant human thioredoxin To be Published
3BA7	Crystal structure of L26N/D28A mutant of Human acidic fibroblast growth factor 分子名称: FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION 著者 Blaber, M, Lee, J. 登録日 2007-11-07 公開日 2008-04-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif. J.Mol.Biol., 377, 2008
3FJI	Crystal structure of K12V/C83I/C117V mutant of Human acidic fibroblast growth factor 分子名称: Heparin-binding growth factor 1, SULFATE ION 著者 Blaber, M, Lee, J. 登録日 2008-12-14 公開日 2009-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine. J.Mol.Biol., 393, 2009
2OZA	Structure of p38alpha complex 分子名称: MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14 著者 White, A, Pargellis, C.A, Studts, J.M, Werneburg, B.G, Farmer II, B.T. 登録日 2007-02-25 公開日 2007-04-03 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular basis of MAPK-activated protein kinase 2:p38 assembly Proc.Natl.Acad.Sci.Usa, 104, 2007
1QYM	X-ray structure of human gankyrin 分子名称: 26S proteasome non-ATPase regulatory subunit 10 著者 Manjasetty, B.A, Quedenau, C, Sievert, V, Buessow, K, Niesen, F, Delbrueck, H, Heinemann, U. 登録日 2003-09-11 公開日 2003-11-18 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 X-ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma. Proteins, 55, 2004
5EML	Crystal structure of PRMT5:MEP50 with Compound 10 and SAM 分子名称: GLYCEROL, Methylosome protein 50, Protein arginine N-methyltransferase 5, ... 著者 Boriack-Sjodin, P.A, Jin, L. 登録日 2015-11-06 公開日 2016-02-24 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med Chem Lett, 7, 2016
2QLV	Crystal structure of the heterotrimer core of the S. cerevisiae AMPK homolog SNF1 分子名称: Carbon catabolite derepressing protein kinase, Nuclear protein SNF4, Protein SIP2 著者 Amodeo, G.A, Rudolph, M.J, Tong, L. 登録日 2007-07-13 公開日 2007-09-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1. Nature, 449, 2007
4KTC	NS3/NS4A protease with inhibitor 分子名称: (2R,6S,13aR,14aR,16aS)-6-{[(cyclopentyloxy)carbonyl]amino}-14a-[(cyclopropylsulfonyl)carbamoyl]-5,16-dioxooctadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 3,4-dihydroisoquinoline-2(1H)-carboxylate, NS4A peptide, Serine protease NS3, ... 著者 Zhang, H, Ballard, J, Vigers, G.P.A, Brandhuber, B.J. 登録日 2013-05-20 公開日 2013-08-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease. J.Med.Chem., 57, 2014
5EMK	Crystal structure of PRMT5:MEP50 with Compound 9 and sinefungin 分子名称: GLYCEROL, Methylosome protein 50, Protein arginine N-methyltransferase 5, ... 著者 Boriack-Sjodin, P.A, Jin, L. 登録日 2015-11-06 公開日 2016-02-24 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med Chem Lett, 7, 2016
5EMJ	Crystal structure of PRMT5:MEP50 with Compound 8 and sinefungin 分子名称: (2~{S})-1-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-3-[[4-(3-methylbenzimidazol-5-yl)pyridin-2-yl]amino]propan-2-ol, GLYCEROL, Methylosome protein 50, ... 著者 Boriack-Sjodin, P.A, Jin, L. 登録日 2015-11-06 公開日 2016-02-24 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (2.273 Å) 主引用文献 Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med Chem Lett, 7, 2016
5EXA	Small-molecule stabilization of the 14-3-3/Gab2 PPI interface 分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, Fusicoccin A-THF derivative, ... 著者 Bier, D, Ottmann, C. 登録日 2015-11-23 公開日 2016-05-04 最終更新日 2018-12-19 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11, 2016
5EWZ	Small-molecule stabilization of the 14-3-3/Gab2 PPI interface 分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, GRB2-associated-binding protein 2 著者 Bier, D, Ottmann, C. 登録日 2015-11-23 公開日 2016-05-04 最終更新日 2018-12-19 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11, 2016
6BC0	A Complex between PH Domain of p190RhoGEF and Activated RhoA Bound to a GTP Analog 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Rho guanine nucleotide exchange factor 28, ... 著者 Chen, Z, Sternweis, P.C. 登録日 2017-10-20 公開日 2017-12-13 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.198 Å) 主引用文献 Direct regulation of p190RhoGEF by activated Rho and Rac GTPases. J. Struct. Biol., 202, 2018
3QFA	Crystal structure of the human thioredoxin reductase-thioredoxin complex 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Thioredoxin, ... 著者 Fritz-Wolf, K, Kehr, S, Stumpf, M, Rahlfs, S, Becker, K. 登録日 2011-01-21 公開日 2011-07-27 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of the human thioredoxin reductase-thioredoxin complex Nat Commun, 2, 2011
6EYC	Re-refinement of the MCM2-7 double hexamer using ISOLDE 分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, ... 著者 Croll, T.I. 登録日 2017-11-11 公開日 2018-06-20 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps. Acta Crystallogr D Struct Biol, 74, 2018
3QFB	Crystal structure of the human thioredoxin reductase-thioredoxin complex 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Thioredoxin, ... 著者 Fritz-Wolf, K, Kehr, S, Stumpf, M, Rahlfs, S, Becker, K. 登録日 2011-01-21 公開日 2011-07-27 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of the human thioredoxin reductase-thioredoxin complex Nat Commun, 2, 2011
8HK5	C5aR1-Gi-C5a protein complex 分子名称: C5a anaphylatoxin chemotactic receptor 1, Complement C5, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. 登録日 2022-11-24 公開日 2023-05-10 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat.Chem.Biol., 19, 2023
7KXT	Crystal structure of human EED 分子名称: 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, Polycomb protein EED, UNKNOWN ATOM OR ION 著者 Zhu, L, Dong, A, Du, D, Liu, Y, Luo, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2020-12-04 公開日 2021-02-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction. J.Med.Chem., 64, 2021
1X86	Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF in complex with RhoA 分子名称: PHOSPHATE ION, Rho guanine nucleotide exchange factor 12, Transforming protein RhoA 著者 Kristelly, R, Gao, G, Tesmer, J.J. 登録日 2004-08-17 公開日 2004-09-21 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.22 Å) 主引用文献 Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. J.Biol.Chem., 279, 2004
8HQC	Structure of a GPCR-G protein in complex with a natural peptide agonist 分子名称: Antibody fragment, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ... 著者 Saha, S, Maharana, J, Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. 登録日 2022-12-13 公開日 2023-10-18 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.89 Å) 主引用文献 Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186, 2023
8HPT	Structure of C5a-pep bound mouse C5aR1 in complex with Go 分子名称: Antibody fragment ScFv16, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Saha, S, Maharana, J, Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. 登録日 2022-12-13 公開日 2023-10-18 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186, 2023
5EMM	Crystal structure of PRMT5:MEP50 with Compound 15 and sinefungin 分子名称: GLYCEROL, Methylosome protein 50, Protein arginine N-methyltransferase 5, ... 著者 Boriack-Sjodin, P.A, Jin, L. 登録日 2015-11-06 公開日 2016-02-24 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med Chem Lett, 7, 2016
8IA2	Structure of C5a bound human C5aR1 in complex with Go (Composite map) 分子名称: Antibody fragment - ScFv16, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ... 著者 Yadav, M.K, Yadav, R, Maharana, J, Banerjee, R, Shukla, A.K, Gati, C. 登録日 2023-02-07 公開日 2023-10-18 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3.21 Å) 主引用文献 Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186, 2023

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