8C79
 
 | | Crystal structure of Leishmania donovani 6-Phosphogluconate Dehydrogenase complexed with NADPH | | Descriptor: | 6-phosphogluconate dehydrogenase, decarboxylating, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Fritz-Wolf, K, Berneburg, I, Rahlfs, S, Becker, K. | | Deposit date: | 2023-01-13 | | Release date: | 2023-05-24 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure of Leishmania donovani 6-Phosphogluconate Dehydrogenase and Inhibition by Phosphine Gold(I) Complexes: A Potential Approach to Leishmaniasis Treatment.
Int J Mol Sci, 24, 2023
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1OKT
 | | X-ray Structure of Glutathione S-Transferase from the Malarial Parasite Plasmodium falciparum | | Descriptor: | FORMIC ACID, GLUTATHIONE S-TRANSFERASE | | Authors: | Fritz-Wolf, K, Becker, A, Rahlfs, s, Harwaldt, P, Schirmer, R.H, Kabsch, W, Becker, K. | | Deposit date: | 2003-07-29 | | Release date: | 2003-11-20 | | Last modified: | 2019-07-24 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | X-Ray Structure of Glutathione S-Transferase from the Malarial Parasite Plasmodium Falciparum
Proc.Natl.Acad.Sci.USA, 100, 2003
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7AOO
 | | Plasmoredoxin, a redox-active protein unique for malaria parasites | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, HEXAETHYLENE GLYCOL, ... | | Authors: | Fritz-Wolf, K, Bathke, J, Rahlfs, S, Becker, K. | | Deposit date: | 2020-10-14 | | Release date: | 2022-04-13 | | Last modified: | 2022-04-27 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of plasmoredoxin, a redox-active protein unique for malaria parasites.
Curr Res Struct Biol, 4, 2022
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5LM3
 | | Plasmodium falciparum nicotinic acid mononucleotide adenylyltransferase complexed with APC | | Descriptor: | 1,2-ETHANEDIOL, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, Nicotinate-nucleotide adenylyltransferase | | Authors: | Bathke, J, Fritz-Wolf, K, Rahlfs, S, Brandstaether, C, Burkhardt, A, Becker, K. | | Deposit date: | 2016-07-29 | | Release date: | 2016-11-30 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural and Functional Characterization of Plasmodium falciparum Nicotinic Acid Mononucleotide Adenylyltransferase.
J. Mol. Biol., 428, 2016
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5LLT
 | | Plasmodium falciparum nicotinic acid mononucleotide adenylyltransferase complexed with NaAD | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, NICOTINIC ACID ADENINE DINUCLEOTIDE, ... | | Authors: | Bathke, J, Fritz-Wolf, K, Brandstaedter, C, Rahlfs, S, Becker, K. | | Deposit date: | 2016-07-28 | | Release date: | 2016-11-30 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural and Functional Characterization of Plasmodium falciparum Nicotinic Acid Mononucleotide Adenylyltransferase.
J. Mol. Biol., 428, 2016
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7AOJ
 | | Plasmoredoxin, a redox-active protein unique for malaria parasites | | Descriptor: | GLYCEROL, Plasmoredoxin | | Authors: | Fritz-Wolf, K, Bathke, J, Rahlfs, S, Becker, K. | | Deposit date: | 2020-10-14 | | Release date: | 2022-04-13 | | Last modified: | 2022-04-27 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | Crystal structure of plasmoredoxin, a redox-active protein unique for malaria parasites.
Curr Res Struct Biol, 4, 2022
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6FQX
 | | Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate | | Descriptor: | 2-(2-ETHOXYETHOXY)ETHANOL, 6-phosphogluconate dehydrogenase, decarboxylating, ... | | Authors: | Fritz-Wolf, K, Haeussler, K, Reichmann, M, Rahlfs, S, Becker, K. | | Deposit date: | 2018-02-15 | | Release date: | 2018-08-22 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target.
J. Mol. Biol., 430, 2018
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6FQZ
 | | Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate | | Descriptor: | 6-PHOSPHOGLUCONIC ACID, 6-phosphogluconate dehydrogenase, decarboxylating, ... | | Authors: | Fritz-Wolf, K, Haeussler, K, Reichmann, M, Rahlfs, S, Becker, K. | | Deposit date: | 2018-02-15 | | Release date: | 2018-08-22 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target.
J. Mol. Biol., 430, 2018
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6FQY
 | | Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate | | Descriptor: | 1,2-ETHANEDIOL, 6-phosphogluconate dehydrogenase, decarboxylating, ... | | Authors: | Fritz-Wolf, K, Haeussler, K, Reichmann, M, Rahlfs, S, Becker, K. | | Deposit date: | 2018-02-15 | | Release date: | 2018-08-22 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target.
J. Mol. Biol., 430, 2018
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4J56
 | | Structure of Plasmodium falciparum thioredoxin reductase-thioredoxin complex | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Thioredoxin, Thioredoxin reductase 2 | | Authors: | Fritz-Wolf, K, Jortzik, E, Stumpf, M, Preuss, J, Iozef, R, Rahlfs, S, Becker, K. | | Deposit date: | 2013-02-08 | | Release date: | 2013-07-10 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.371 Å) | | Cite: | Crystal Structure of the Plasmodium falciparum Thioredoxin Reductase-Thioredoxin Complex.
J.Mol.Biol., 425, 2013
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3QFA
 | | Crystal structure of the human thioredoxin reductase-thioredoxin complex | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Thioredoxin, ... | | Authors: | Fritz-Wolf, K, Kehr, S, Stumpf, M, Rahlfs, S, Becker, K. | | Deposit date: | 2011-01-21 | | Release date: | 2011-07-27 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of the human thioredoxin reductase-thioredoxin complex
Nat Commun, 2, 2011
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3QFB
 | | Crystal structure of the human thioredoxin reductase-thioredoxin complex | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Thioredoxin, ... | | Authors: | Fritz-Wolf, K, Kehr, S, Stumpf, M, Rahlfs, S, Becker, K. | | Deposit date: | 2011-01-21 | | Release date: | 2011-07-27 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of the human thioredoxin reductase-thioredoxin complex
Nat Commun, 2, 2011
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4J57
 | | Structure of Plasmodium falciparum thioredoxin reductase-thioredoxin complex | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Thioredoxin, ... | | Authors: | Fritz-Wolf, K, Jortzik, E, Stumpf, M, Preuss, J, Iozef, R, Rahlfs, S, Becker, K. | | Deposit date: | 2013-02-08 | | Release date: | 2013-07-10 | | Last modified: | 2017-11-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of the Plasmodium falciparum Thioredoxin Reductase-Thioredoxin Complex.
J.Mol.Biol., 425, 2013
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3R3J
 | | Kinetic and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2 | | Descriptor: | Glutamate dehydrogenase | | Authors: | Zocher, K, Fritz-Wolf, K, Kehr, S, Rahlfs, S, Becker, K. | | Deposit date: | 2011-03-16 | | Release date: | 2012-03-07 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2.
Mol.Biochem.Parasitol., 183, 2012
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7ZZI
 | | Plasmodium falciparum hexokinase complexed with glucose and citrate | | Descriptor: | 1,2-ETHANEDIOL, CITRIC ACID, Phosphotransferase, ... | | Authors: | Fritz-Wolf, K, Dillenberger, M, Rahlfs, S, Becker, K. | | Deposit date: | 2022-05-25 | | Release date: | 2023-08-30 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Analysis of Plasmodium falciparum Hexokinase Provides Novel Information about Catalysis Due to a Plasmodium -Specific Insertion.
Int J Mol Sci, 24, 2023
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7Z4N
 | | Plasmodium falciparum pyruvate kinase complexed with pyruvate | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | Authors: | Dillenberger, M, Rahlfs, S, Becker, K, Fritz-Wolf, K. | | Deposit date: | 2022-03-04 | | Release date: | 2022-08-24 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity.
Structure, 30, 2022
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7Z4M
 | | Plasmodium falciparum pyruvate kinase complexed with Mg2+ and K+ | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Dillenberger, M, Rahlfs, S, Becker, K, Fritz-Wolf, K. | | Deposit date: | 2022-03-04 | | Release date: | 2022-08-24 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity.
Structure, 30, 2022
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7Z4Q
 | | Plasmodium falciparum pyruvate kinase mutant - C49A | | Descriptor: | MAGNESIUM ION, Pyruvate kinase | | Authors: | Dillenberger, M, Rahlfs, S, Becker, K, Fritz-Wolf, K. | | Deposit date: | 2022-03-04 | | Release date: | 2022-08-24 | | Last modified: | 2022-10-19 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity.
Structure, 30, 2022
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7Z4R
 | | Plasmodium falciparum pyruvate kinase mutant - C343A | | Descriptor: | MAGNESIUM ION, POTASSIUM ION, Pyruvate kinase | | Authors: | Dillenberger, M, Rahlfs, S, Becker, K, Fritz-Wolf, K. | | Deposit date: | 2022-03-04 | | Release date: | 2022-08-24 | | Last modified: | 2022-10-19 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity.
Structure, 30, 2022
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