8C79

Crystal structure of Leishmania donovani 6-Phosphogluconate Dehydrogenase complexed with NADPH

Summary for 8C79

• Entry DOI: 10.2210/pdb8c79/pdb
• Descriptor: 6-phosphogluconate dehydrogenase, decarboxylating, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: leishmania donovani, trypanosoma, pentose phosphate pathway, 6-phosphogluconate dehydrogenase, oxidoreductase, antioxidant defense, drug target
• Biological source: Leishmania donovani
• Total number of polymer chains: 2
• Total formula weight: 105416.71

Authors

Fritz-Wolf, K.,Berneburg, I.,Rahlfs, S.,Becker, K. (deposition date: 2023-01-13, release date: 2023-05-24, Last modification date: 2024-02-07)

• Primary citation: Berneburg, I.,Stumpf, M.,Velten, A.S.,Rahlfs, S.,Przyborski, J.,Becker, K.,Fritz-Wolf, K.; Structure of Leishmania donovani 6-Phosphogluconate Dehydrogenase and Inhibition by Phosphine Gold(I) Complexes: A Potential Approach to Leishmaniasis Treatment.; Int J Mol Sci, 24:-, 2023; PubMed: 37239962; DOI: 10.3390/ijms24108615

Experimental method

X-RAY DIFFRACTION (3.1 Å)