7KXT

Crystal structure of human EED

Summary for 7KXT

Entry DOI	10.2210/pdb7kxt/pdb
Descriptor	Polycomb protein EED, 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, UNKNOWN ATOM OR ION, ... (4 entities in total)
Functional Keywords	eed, wd40, structural genomics, structural genomics consortium, sgc, gene regulation
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	93233.84
Authors	Zhu, L.,Dong, A.,Du, D.,Liu, Y.,Luo, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2020-12-04, release date: 2021-02-24, Last modification date: 2023-10-18)
Primary citation	Du, D.,Xu, D.,Zhu, L.,Stazi, G.,Zwergel, C.,Liu, Y.,Luo, Z.,Li, Y.,Zhang, Y.,Zhu, K.,Ding, Y.,Liu, J.,Fan, S.,Zhao, K.,Zhang, N.,Kong, X.,Jiang, H.,Chen, K.,Zhao, K.,Valente, S.,Min, J.,Duan, W.,Luo, C. Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction. J.Med.Chem., 64:8194-8207, 2021 Cited by PubMed: 34077206 DOI: 10.1021/acs.jmedchem.0c02261 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation