7KXT
Crystal structure of human EED
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0001222 | molecular_function | transcription corepressor binding |
| A | 0001739 | cellular_component | sex chromatin |
| A | 0003682 | molecular_function | chromatin binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005677 | cellular_component | chromatin silencing complex |
| A | 0005694 | cellular_component | chromosome |
| A | 0006325 | biological_process | chromatin organization |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0008047 | molecular_function | enzyme activator activity |
| A | 0021510 | biological_process | spinal cord development |
| A | 0031491 | molecular_function | nucleosome binding |
| A | 0031507 | biological_process | heterochromatin formation |
| A | 0035098 | cellular_component | ESC/E(Z) complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045120 | cellular_component | pronucleus |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0140718 | biological_process | facultative heterochromatin formation |
| A | 1990841 | molecular_function | promoter-specific chromatin binding |
| B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| B | 0001222 | molecular_function | transcription corepressor binding |
| B | 0001739 | cellular_component | sex chromatin |
| B | 0003682 | molecular_function | chromatin binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005677 | cellular_component | chromatin silencing complex |
| B | 0005694 | cellular_component | chromosome |
| B | 0006325 | biological_process | chromatin organization |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0008047 | molecular_function | enzyme activator activity |
| B | 0021510 | biological_process | spinal cord development |
| B | 0031491 | molecular_function | nucleosome binding |
| B | 0031507 | biological_process | heterochromatin formation |
| B | 0035098 | cellular_component | ESC/E(Z) complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045120 | cellular_component | pronucleus |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0140718 | biological_process | facultative heterochromatin formation |
| B | 1990841 | molecular_function | promoter-specific chromatin binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue XB7 A 501 |
| Chain | Residue |
| A | LEU246 |
| A | VAL393 |
| A | GLU394 |
| A | PRO396 |
| A | HIS397 |
| B | GLU394 |
| B | ASP395 |
| A | LEU315 |
| A | GLY316 |
| A | LEU318 |
| A | MET336 |
| A | PHE356 |
| A | PHE372 |
| A | TRP373 |
| A | LEU391 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue XB7 B 501 |
| Chain | Residue |
| B | LEU246 |
| B | LEU315 |
| B | GLY316 |
| B | MET336 |
| B | PHE356 |
| B | PHE372 |
| B | TRP373 |
| B | GLN374 |
| B | LEU391 |
| B | VAL393 |
| B | GLU394 |
| B | PRO396 |
| B | HIS397 |
| B | HOH631 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI |
| Chain | Residue | Details |
| A | LEU206-ILE220 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"WD 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 86 |
| Details | Repeat: {"description":"WD 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"WD 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"WD 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 74 |
| Details | Repeat: {"description":"WD 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"WD 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"WD 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 360 |
| Details | Region: {"description":"Interaction with EZH2","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 448 |
| Details | Region: {"description":"Required for interaction with the matrix protein MA of HIV-1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"20974918","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
