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7KXT

Crystal structure of human EED

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001222molecular_functiontranscription corepressor binding
A0003682molecular_functionchromatin binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005829cellular_componentcytosol
A0006325biological_processchromatin organization
A0008047molecular_functionenzyme activator activity
A0021510biological_processspinal cord development
A0031491molecular_functionnucleosome binding
A0031507biological_processheterochromatin formation
A0035098cellular_componentESC/E(Z) complex
A0042054molecular_functionhistone methyltransferase activity
A0042802molecular_functionidentical protein binding
A0045892biological_processnegative regulation of DNA-templated transcription
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001222molecular_functiontranscription corepressor binding
B0003682molecular_functionchromatin binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005829cellular_componentcytosol
B0006325biological_processchromatin organization
B0008047molecular_functionenzyme activator activity
B0021510biological_processspinal cord development
B0031491molecular_functionnucleosome binding
B0031507biological_processheterochromatin formation
B0035098cellular_componentESC/E(Z) complex
B0042054molecular_functionhistone methyltransferase activity
B0042802molecular_functionidentical protein binding
B0045892biological_processnegative regulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue XB7 A 501
ChainResidue
ALEU246
AVAL393
AGLU394
APRO396
AHIS397
BGLU394
BASP395
ALEU315
AGLY316
ALEU318
AMET336
APHE356
APHE372
ATRP373
ALEU391

site_idAC2
Number of Residues14
Detailsbinding site for residue XB7 B 501
ChainResidue
BLEU246
BLEU315
BGLY316
BMET336
BPHE356
BPHE372
BTRP373
BGLN374
BLEU391
BVAL393
BGLU394
BPRO396
BHIS397
BHOH631

Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI
ChainResidueDetails
ALEU206-ILE220

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ATHR55
BTHR55

site_idSWS_FT_FI2
Number of Residues8
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:20974918
ChainResidueDetails
ALYS66
ALYS197
ALYS268
ALYS284
BLYS66
BLYS197
BLYS268
BLYS284

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PDB entries from 2024-07-17

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