6BC0

A Complex between PH Domain of p190RhoGEF and Activated RhoA Bound to a GTP Analog

Summary for 6BC0

Entry DOI	10.2210/pdb6bc0/pdb
Descriptor	Rho guanine nucleotide exchange factor 28, Transforming protein RhoA, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	rho gtpase guanine nucleotide exchange factors rhogef pleckstrin homology ph domain, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	38962.63
Authors	Chen, Z.,Sternweis, P.C. (deposition date: 2017-10-20, release date: 2017-12-13, Last modification date: 2024-03-13)
Primary citation	Dada, O.,Gutowski, S.,Brautigam, C.A.,Chen, Z.,Sternweis, P.C. Direct regulation of p190RhoGEF by activated Rho and Rac GTPases. J. Struct. Biol., 202:13-24, 2018 Cited by PubMed: 29196061 DOI: 10.1016/j.jsb.2017.11.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.198 Å)

Structure validation