PDB: 2461 件ウェブページステータス検索Chemie searchBIRD

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6C2Y	Human GRK2 in complex with Gbetagamma subunits and CCG257142 分子名称: (4R,5R,6S)-4-[4-fluoro-3-({[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]methyl}carbamoyl)phenyl]-N-(2H-indazol-5-yl)-6-methyl-2-oxohexahydropyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Bouley, R, Tesmer, J.J.G. 登録日 2018-01-09 公開日 2018-04-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors. Bioorg. Med. Chem. Lett., 28, 2018
6C0F	Yeast nucleolar pre-60S ribosomal subunit (state 2) 分子名称: 5.8S rRNA, 60S ribosomal protein L13-A, 60S ribosomal protein L14-A, ... 著者 Sanghai, Z.A, Miller, L, Barandun, J, Hunziker, M, Chaker-Margot, M, Klinge, S. 登録日 2017-12-29 公開日 2018-03-14 最終更新日 2020-01-08 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Modular assembly of the nucleolar pre-60S ribosomal subunit. Nature, 556, 2018
6CMO	Rhodopsin-Gi complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab Heavy chain, Fab light chain, ... 著者 Kang, Y, Kuybeda, O, de Waal, P.W, Mukherjee, S, Van Eps, N, Dutka, P, Zhou, X.E, Bartesaghi, A, Erramilli, S, Morizumi, T, Gu, X, Yin, Y, Liu, P, Jiang, Y, Meng, X, Zhao, G, Melcher, K, Earnst, O.P, Kossiakoff, A.A, Subramaniam, S, Xu, H.E. 登録日 2018-03-05 公開日 2018-06-20 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. Nature, 558, 2018
6CB1	Yeast nucleolar pre-60S ribosomal subunit (state 3) 分子名称: 35S pre-ribosomal RNA miscRNA, 5.8S rRNA, 60S ribosomal protein L13-A, ... 著者 Sanghai, Z.A, Miller, L, Barandun, J, Hunziker, M, Chaker-Margot, M, Klinge, S. 登録日 2018-02-01 公開日 2018-03-14 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Modular assembly of the nucleolar pre-60S ribosomal subunit. Nature, 556, 2018
6ID0	Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... 著者 Zhang, X, Zhan, X, Yan, C, Shi, Y. 登録日 2018-09-07 公開日 2019-03-13 最終更新日 2020-10-14 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
6ICZ	Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... 著者 Zhang, X, Zhan, X, Yan, C, Shi, Y. 登録日 2018-09-07 公開日 2019-03-13 最終更新日 2020-10-14 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
6IP6	Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii) 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... 著者 Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T. 登録日 2018-11-02 公開日 2019-05-29 最終更新日 2019-11-06 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 HCV IRES Captures an Actively Translating 80S Ribosome. Mol.Cell, 74, 2019
6IP8	Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv) 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... 著者 Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T. 登録日 2018-11-02 公開日 2019-05-29 最終更新日 2019-11-06 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 HCV IRES Captures an Actively Translating 80S Ribosome. Mol.Cell, 74, 2019
6IP5	Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii) 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... 著者 Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T. 登録日 2018-11-02 公開日 2019-05-29 最終更新日 2019-11-06 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 HCV IRES Captures an Actively Translating 80S Ribosome. Mol.Cell, 74, 2019
6J6G	Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom 分子名称: ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... 著者 Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. 登録日 2019-01-15 公開日 2019-04-24 最終更新日 2020-10-14 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
6GQV	Cryo-EM recosntruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP) 分子名称: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... 著者 Pellegrino, S, Yusupov, M, Yusupova, G, Hashem, Y. 登録日 2018-06-08 公開日 2018-07-11 最終更新日 2018-08-08 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance. J. Mol. Biol., 430, 2018
6GZ3	tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-1 (TI-POST-1) 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... 著者 Flis, J, Holm, M, Rundlet, E.J, Loerke, J, Hilal, T, Dabrowski, M, Buerger, J, Mielke, T, Blanchard, S.C, Spahn, C.M.T, Budkevich, T.V. 登録日 2018-07-03 公開日 2018-12-05 最終更新日 2022-03-30 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis. Cell Rep, 25, 2018
5TZS	Architecture of the yeast small subunit processome 分子名称: 13 kDa ribonucleoprotein-associated protein, 18S ribosomal RNA, 3' domain-associated, ... 著者 Chaker-Margot, M, Barandun, J, Hunziker, M, Klinge, S. 登録日 2016-11-22 公開日 2016-12-21 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (5.1 Å) 主引用文献 Architecture of the yeast small subunit processome. Science, 355, 2017
6GSM	Structure of a partial yeast 48S preinitiation complex in open conformation. 分子名称: 18S ribosomal RNA, 40S ribosomal protein S0, 40S ribosomal protein S1, ... 著者 Llacer, J.L, Hussain, T, Gordiyenko, Y, Ramakrishnan, V. 登録日 2018-06-14 公開日 2019-07-31 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (5.15 Å) 主引用文献 Large-scale movement of eIF3 domains during translation initiation modulate start codon selection. Nucleic Acids Res., 2021
5T2C	CryoEM structure of the human ribosome at 3.6 Angstrom resolution 分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... 著者 Zhang, X, Lai, M, Zhou, Z.H. 登録日 2016-08-23 公開日 2017-01-25 最終更新日 2023-08-16 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes. Nat Commun, 7, 2016
6HHQ	Crystal structure of compound C45 bound to the yeast 80S ribosome 分子名称: (3~{R})-3-[(1~{S})-2-[(1~{S},4~{a}~{R},6~{S},7~{S},8~{a}~{R})-6,7-bis(chloranyl)-5,5,8~{a}-trimethyl-2-methylidene-3,4,4~{a},6,7,8-hexahydro-1~{H}-naphthalen-1-yl]-1-oxidanyl-ethyl]pyrrolidine-2,5-dione, 18S ribosomal RNA, 25S ribosomal RNA, ... 著者 Pellegrino, S, Vanderwal, C.D, Yusupov, M. 登録日 2018-08-28 公開日 2019-02-20 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (3.10000038 Å) 主引用文献 Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome. Nucleic Acids Res., 47, 2019
6HCQ	Structure of the rabbit collided di-ribosome (collided monosome) 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... 著者 Juszkiewicz, S, Chandrasekaran, V, Lin, Z, Kraatz, S, Ramakrishnan, V, Hegde, R.S. 登録日 2018-08-16 公開日 2018-10-17 最終更新日 2018-11-14 実験手法 ELECTRON MICROSCOPY (6.5 Å) 主引用文献 ZNF598 Is a Quality Control Sensor of Collided Ribosomes. Mol. Cell, 72, 2018
6HCJ	Structure of the rabbit 80S ribosome on globin mRNA in the rotated state with A/P and P/E tRNAs 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... 著者 Juszkiewicz, S, Chandrasekaran, V, Lin, Z, Kraatz, S, Ramakrishnan, V, Hegde, R.S. 登録日 2018-08-15 公開日 2018-10-17 最終更新日 2018-11-14 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 ZNF598 Is a Quality Control Sensor of Collided Ribosomes. Mol. Cell, 72, 2018
6J6H	Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom 分子名称: ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... 著者 Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. 登録日 2019-01-15 公開日 2019-04-24 最終更新日 2020-10-14 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
6J6N	Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom 分子名称: GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... 著者 Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. 登録日 2019-01-15 公開日 2019-04-24 最終更新日 2020-10-14 実験手法 ELECTRON MICROSCOPY (3.86 Å) 主引用文献 Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
6J6Q	Cryo-EM structure of the yeast B*-b2 complex at an average resolution of 3.7 angstrom 分子名称: GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... 著者 Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. 登録日 2019-01-15 公開日 2019-04-24 最終更新日 2020-10-14 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
6HCM	Structure of the rabbit collided di-ribosome (stalled monosome) 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... 著者 Juszkiewicz, S, Chandrasekaran, V, Lin, Z, Kraatz, S, Ramakrishnan, V, Hegde, R.S. 登録日 2018-08-15 公開日 2018-10-17 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (6.8 Å) 主引用文献 ZNF598 Is a Quality Control Sensor of Collided Ribosomes. Mol. Cell, 72, 2018
5TGM	Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro 分子名称: 18S ribosomal RNA, 25S ribosomal RNA, 3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate), ... 著者 Melnikov, S, Mailliot, J, Yusupov, M. 登録日 2016-09-28 公開日 2017-01-18 最終更新日 2022-12-07 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Molecular insights into protein synthesis with proline residues. EMBO Rep., 17, 2016
5TBW	Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome 分子名称: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... 著者 Konst, Z.A, Szklarski, A.R, Pellegrino, S, Michalak, S.E, Meyer, M, Zanette, C, Cencic, R, Nam, S, Horne, D.A, Pelletier, J, Mobley, D.L, Yusupova, G, Yusupov, M, Vanderwal, C.D. 登録日 2016-09-13 公開日 2017-07-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides. Nat Chem, 9, 2017
5TGA	Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro 分子名称: 18S ribosomal RNA, 25S ribosomal RNA, 3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate), ... 著者 Melnikov, S, Mailliot, J. 登録日 2016-09-27 公開日 2016-11-23 最終更新日 2016-12-14 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Molecular insights into protein synthesis with proline residues. EMBO Rep., 17, 2016

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