Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii)

This is a large structure.

Summary for 6IP6

EMDB information9701 9699 9702 9703 9704
Descriptor28S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ... (83 entities in total)
Functional Keywordsribosome, translation
Biological sourceHomo sapiens (Human)
Total number of polymer chains83
Total molecular weight3901521.39
Yokoyama, T.,Shigematsu, H.,Shirouzu, M.,Imataka, H.,Ito, T. (deposition date: 2018-11-02, release date: 2019-05-29, Last modification date: 2019-07-03)
Primary citation
Yokoyama, T.,Machida, K.,Iwasaki, W.,Shigeta, T.,Nishimoto, M.,Takahashi, M.,Sakamoto, A.,Yonemochi, M.,Harada, Y.,Shigematsu, H.,Shirouzu, M.,Tadakuma, H.,Imataka, H.,Ito, T.
HCV IRES Captures an Actively Translating 80S Ribosome.
Mol.Cell, 74:1205-1214.e8, 2019
PubMed: 31080011 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2019.04.022
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone8 0.3% 0.2% 0.39MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures