Crystal structure of compound C45 bound to the yeast 80S ribosome

This is a large structure.

Summary for 6HHQ

Descriptor25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ... (86 entities in total)
Functional Keywords80s ribosome, inhibitor, anti-cancer, ribosome
Biological sourceSaccharomyces cerevisiae
Total number of polymer chains159
Total molecular weight6646164.98
Pellegrino, S.,Vanderwal, C.D.,Yusupov, M. (deposition date: 2018-08-28, release date: 2019-02-20, Last modification date: 2019-04-17)
Primary citation
Pellegrino, S.,Meyer, M.,Konst, Z.A.,Holm, M.,Voora, V.K.,Kashinskaya, D.,Zanette, C.,Mobley, D.L.,Yusupova, G.,Vanderwal, C.D.,Blanchard, S.C.,Yusupov, M.
Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome.
Nucleic Acids Res., 47:3223-3232, 2019
PubMed: 30759226 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkz053
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.10000049683 Å)

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone 0.26514 0.9% 16.5% 4.2% 0.46MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report