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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6HHQ

Crystal structure of compound C45 bound to the yeast 80S ribosome

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
11, AR25S ribosomal RNApolymer33961097493.92GenBank (834774822)Saccharomyces cerevisiae
23, AS5S ribosomal RNApolymer12138951.12GenBank (1329886537)Saccharomyces cerevisiae
34, AT5.8S ribosomal RNApolymer15850682.92GenBank (1398978137)Saccharomyces cerevisiae
4j, CD60S ribosomal protein L2-Apolymer25427463.62UniProt (P0CX45)
Pfam (PF03947)
Pfam (PF00181)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L5,Large ribosomal subunit protein uL2-A,RP8,YL6
5k, CE60S ribosomal protein L3polymer38743850.82UniProt (P14126)
Pfam (PF00297)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Large ribosomal subunit protein uL3,Maintenance of killer protein 8,RP1,Trichodermin resistance protein,YL1
6l, CF60S ribosomal protein L4-Apolymer36239159.12UniProt (P10664)
Pfam (PF00573)
Pfam (PF14374)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L2,Large ribosomal subunit protein uL4-A,RP2,YL2
7m, CG60S ribosomal protein L5polymer29733764.82UniProt (P26321)
Pfam (PF14204)
Pfam (PF17144)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L1,L1a,Large ribosomal subunit protein uL18,Ribosomal 5S RNA-binding protein,YL3
8n, CH60S ribosomal protein L6-Apolymer17620000.62UniProt (Q02326)
Pfam (PF01159)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L17,Large ribosomal subunit protein eL6-A,RP18,YL16
9o, CI60S ribosomal protein L7-Apolymer24427686.32UniProt (P05737)
Pfam (PF00327)
Pfam (PF08079)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L6,Large ribosomal subunit protein uL30-A,RP11,YL8
10p, CJ60S ribosomal protein L8-Apolymer25628175.82UniProt (P17076)
Pfam (PF01248)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L4,L4-2,L7a-1,Large ribosomal subunit protein eL8-A,Maintenance of killer protein 7,RP6,YL5
11q, CK60S ribosomal protein L9-Apolymer19121605.12UniProt (P05738)
Pfam (PF00347)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L8,Large ribosomal subunit protein uL6-A,RP24,YL11
12r, CL60S ribosomal protein L10polymer22125410.52UniProt (P41805)
Pfam (PF00252)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L9,Large ribosomal subunit protein uL16,Ubiquinol-cytochrome C reductase complex subunit VI-requiring protein
13s, CM60S ribosomal protein L11-Bpolymer17419785.72UniProt (Q3E757)
Pfam (PF00281)
Pfam (PF00673)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L16,Large ribosomal subunit protein uL5-B,RP39,YL22
14t, CN60S ribosomal protein L13-Apolymer19922604.22UniProt (Q12690)
Pfam (PF01294)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Large ribosomal subunit protein eL13-A
15u, CO60S ribosomal protein L14-Apolymer13815195.12UniProt (P36105)
Pfam (PF00467)
Pfam (PF01929)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Large ribosomal subunit protein eL14-A
16v, CP60S ribosomal protein L15-Apolymer20424482.42UniProt (P05748)
Pfam (PF00827)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L13,Large ribosomal subunit protein eL15-A,RP15R,YL10,YP18
17w, CQ60S ribosomal protein L16-Apolymer19922247.22UniProt (P26784)
Pfam (PF00572)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L13a,L21,Large ribosomal subunit protein uL13-A,RP22,YL15
18x, CR60S ribosomal protein L17-Apolymer18420589.52UniProt (P05740)
Pfam (PF00237)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L20A,Large ribosomal subunit protein uL22-A,YL17
19y, CS60S ribosomal protein L18-Apolymer18620609.32UniProt (P0CX49)
Pfam (PF17135)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Large ribosomal subunit protein eL18-A,RP28
20z, CT60S ribosomal protein L19-Apolymer18921762.32UniProt (P0CX82)
Pfam (PF01280)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L23,Large ribosomal subunit protein eL19-A,RP15L,RP33,YL14
210, CU60S ribosomal protein L20-Apolymer17220478.92UniProt (P0CX23)
Pfam (PF01775)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L18a,Large ribosomal subunit protein eL20-A
222, CV60S ribosomal protein L21-Apolymer16018279.32UniProt (Q02753)
Pfam (PF01157)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Large ribosomal subunit protein eL21-A
235, CW60S ribosomal protein L22-Apolymer12113711.42UniProt (P05749)
Pfam (PF01776)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L1c,Large ribosomal subunit protein eL22-A,RP4,YL31
246, CX60S ribosomal protein L23-Apolymer13714494.02UniProt (P0CX41)
Pfam (PF00238)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L17a,Large ribosomal subunit protein uL14-A,YL32
257, CY60S ribosomal protein L24-Apolymer15517661.72UniProt (P04449)
Pfam (PF01246)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L30,Large ribosomal subunit protein eL24-A,RP29,YL21
268, CZ60S ribosomal protein L25polymer14215787.62UniProt (P04456)
Pfam (PF03939)
Pfam (PF00276)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Large ribosomal subunit protein uL23,RP16L,YL25,YP42'
279, DA60S ribosomal protein L26-Apolymer12714265.82UniProt (P05743)
Pfam (PF16906)
Pfam (PF00467)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L33,Large ribosomal subunit protein uL24-A,YL33
28AA, DB60S ribosomal protein L27-Apolymer13615568.42UniProt (P0C2H6)
Pfam (PF01777)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Large ribosomal subunit protein eL27-A
29AB, DC60S ribosomal protein L28polymer14916761.72UniProt (P02406)
Pfam (PF00828)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L27a,L29,Large ribosomal subunit protein uL15,RP44,RP62,YL24
30AC, DD60S ribosomal protein L29polymer596691.92UniProt (P05747)
Pfam (PF01779)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Large ribosomal subunit protein eL29,YL43
31AD, DE60S ribosomal protein L30polymer10511430.42UniProt (P14120)
Pfam (PF01248)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L32,Large ribosomal subunit protein eL30,RP73,YL38
32AE, DF60S ribosomal protein L31-Apolymer11312980.22UniProt (P0C2H8)
Pfam (PF01198)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L34,Large ribosomal subunit protein eL31-A,YL28
33AF, DG60S ribosomal protein L32polymer13014809.42UniProt (P38061)
Pfam (PF01655)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Large ribosomal subunit protein eL32
34AG, DH60S ribosomal protein L33-Apolymer10712177.12UniProt (P05744)
Pfam (PF01247)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L37,Large ribosomal subunit protein eL33-A,RP47,YL37
35AH, DI60S ribosomal protein L34-Apolymer12113673.22UniProt (P87262)
Pfam (PF01199)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Large ribosomal subunit protein eL34-A
36AI, DJ60S ribosomal protein L35-Apolymer12013942.62UniProt (P0CX84)
Pfam (PF00831)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Large ribosomal subunit protein uL29-A
37AJ, DK60S ribosomal protein L36-Apolymer10011151.32UniProt (P05745)
Pfam (PF01158)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L39,Large ribosomal subunit protein eL36-A,YL39
38AK, DL60S ribosomal protein L37-Apolymer889877.42UniProt (P49166)
Pfam (PF01907)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L43,Large ribosomal subunit protein eL37-A,YL35,YP55
39AL, DM60S ribosomal protein L38polymer788845.62UniProt (P49167)
Pfam (PF01781)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Large ribosomal subunit protein eL38
40AM, DN60S ribosomal protein L39polymer516358.62UniProt (P04650)
Pfam (PF00832)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L46,Large ribosomal subunit protein eL39,YL40
41AN, DOUbiquitin-60S ribosomal protein L40polymer12814583.12UniProt (P0CH08)
Pfam (PF00240)
Pfam (PF01020)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
42AO, DP60S ribosomal protein L41-Bpolymer253354.22UniProt (P0CX87)
Pfam (PF05162)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L47,Large ribosomal subunit protein eL41-B,YL41
43AP, DQ60S ribosomal protein L42-Apolymer10612246.72UniProt (P0CX27)
Pfam (PF00935)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L41,Large ribosomal subunit protein eL42-A,YL27,YP44
44AQ, DR60S ribosomal protein L43-Apolymer9210113.02UniProt (P0CX25)
Pfam (PF01780)
In PDB		Saccharomyces cerevisiae (Baker's yeast)L37a,Large ribosomal subunit protein eL43-A,YL35
45i, sMSuppressor protein STM1polymer27330048.02UniProt (P39015)
Pfam (PF09598)
In PDB		Saccharomyces cerevisiae (Baker's yeast)3BP1,GU4 nucleic-binding protein 2,G4p2 protein,POP2 multicopy suppressor protein 4,Ribosomal subunits association factor,AF,TOM1 suppressor protein 1,Triplex-binding protein 1
46p060S acidic ribosomal protein P0polymer31233749.11UniProt (P05317)
Pfam (PF00428)
Pfam (PF00466)
Pfam (PF17777)
In PDB		Saccharomyces cerevisiae (Baker's yeast)A0,L10e,Large ribosomal subunit protein uL10
47A18S ribosomal RNApolymer1797578820.41GenBank (1329886537)Saccharomyces cerevisiae
48B, s040S ribosomal protein S0-Apolymer25228051.32UniProt (P32905)
Pfam (PF00318)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Nucleic acid-binding protein NAB1A,Small ribosomal subunit protein uS2-A
49C, s140S ribosomal protein S1-Apolymer25528798.52UniProt (P33442)
Pfam (PF01015)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP10A,Small ribosomal subunit protein eS1-A
50D, s240S ribosomal protein S2polymer25427490.82UniProt (P25443)
Pfam (PF00333)
Pfam (PF03719)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Omnipotent suppressor protein SUP44,RP12,S4,Small ribosomal subunit protein uS5,YS5
51E, s340S ribosomal protein S3polymer24026542.82UniProt (P05750)
Pfam (PF07650)
Pfam (PF00189)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP13,Small ribosomal subunit protein uS3,YS3
52F, s440S ribosomal protein S4-Apolymer26129469.32UniProt (P0CX35)
Pfam (PF08071)
Pfam (PF01479)
Pfam (PF00900)
Pfam (PF00467)
Pfam (PF16121)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP5,S7,Small ribosomal subunit protein eS4-A,YS6
53G, s540S ribosomal protein S5polymer22525072.62UniProt (P26783)
Pfam (PF00177)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP14,S2,Small ribosomal subunit protein uS7,YS8
54H, s640S ribosomal protein S6-Apolymer23627054.52UniProt (P0CX37)
Pfam (PF01092)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP9,S10,Small ribosomal subunit protein eS6-A,YS4
55I, s740S ribosomal protein S7-Apolymer19021658.22UniProt (P26786)
Pfam (PF01251)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP30,RP40,Small ribosomal subunit protein eS7-A
56J, s840S ribosomal protein S8-Apolymer20022537.82UniProt (P0CX39)
Pfam (PF01201)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP19,S14,Small ribosomal subunit protein eS8-A,YS9
57K, s940S ribosomal protein S9-Apolymer19722487.92UniProt (O13516)
Pfam (PF00163)
Pfam (PF01479)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP21,S13,Small ribosomal subunit protein uS4-A,YP28,YS11
58L, c040S ribosomal protein S10-Apolymer10512757.42UniProt (Q08745)
Pfam (PF03501)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Small ribosomal subunit protein eS10-A
59M, c140S ribosomal protein S11-Apolymer15617785.92UniProt (P0CX47)
Pfam (PF16205)
Pfam (PF00366)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP41,S18,Small ribosomal subunit protein uS17-A,YS12
60N, c240S ribosomal protein S12polymer14315488.62UniProt (P48589)
Pfam (PF01248)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Small ribosomal subunit protein eS12
61O, c340S ribosomal protein S13polymer15117059.92UniProt (P05756)
Pfam (PF08069)
Pfam (PF00312)
In PDB		Saccharomyces cerevisiae (Baker's yeast)S27a,Small ribosomal subunit protein uS15,YS15
62P, c440S ribosomal protein S14-Bpolymer13814675.82UniProt (P39516)
Pfam (PF00411)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP59B,Small ribosomal subunit protein uS11-B
63Q, c540S ribosomal protein S15polymer14216031.92UniProt (Q01855)
Pfam (PF00203)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RIG protein,RP52,S21,Small ribosomal subunit protein uS19,YS21
64R, c640S ribosomal protein S16-Apolymer14315877.52UniProt (P0CX51)
Pfam (PF00380)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP61R,Small ribosomal subunit protein uS9-A
65S, c740S ribosomal protein S17-Apolymer13615820.42UniProt (P02407)
Pfam (PF00833)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP51A,Small ribosomal subunit protein eS17-A
66T, c840S ribosomal protein S18-Apolymer14617071.62UniProt (P0CX55)
Pfam (PF00416)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Small ribosomal subunit protein uS13-A
67U, c940S ribosomal protein S19-Apolymer14415942.12UniProt (P07280)
Pfam (PF01090)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP55A,S16a,Small ribosomal subunit protein eS19-A,YP45,YS16A
68V, d040S ribosomal protein S20polymer12113929.02UniProt (P38701)
Pfam (PF00338)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Small ribosomal subunit protein uS10
69W, d140S ribosomal protein S21-Apolymer879758.82UniProt (P0C0V8)
Pfam (PF01249)
In PDB		Saccharomyces cerevisiae (Baker's yeast)S26,Small ribosomal subunit protein eS21-A,YS25
70X, d240S ribosomal protein S22-Apolymer13014650.12UniProt (P0C0W1)
Pfam (PF00410)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP50,S24,Small ribosomal subunit protein uS8-A,YP58,YS22
71Y, d340S ribosomal protein S23-Apolymer14516073.92UniProt (P0CX29)
Pfam (PF00164)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP37,S28,Small ribosomal subunit protein uS12-A,YS14
72Z, d440S ribosomal protein S24-Apolymer13515362.82UniProt (P0CX31)
Pfam (PF01282)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP50,Small ribosomal subunit protein eS24-A
73a, d540S ribosomal protein S25-Apolymer10812067.32UniProt (Q3E792)
Pfam (PF03297)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP45,S31,Small ribosomal subunit protein eS25-A,YS23
74b, d640S ribosomal protein S26-Bpolymer11913480.92UniProt (P39939)
Pfam (PF01283)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Small ribosomal subunit protein eS26-B
75c, d740S ribosomal protein S27-Apolymer828893.42UniProt (P35997)
Pfam (PF01667)
In PDB		Saccharomyces cerevisiae (Baker's yeast)RP61,Small ribosomal subunit protein eS27-A,YS20
76d, d840S ribosomal protein S28-Apolymer677605.82UniProt (Q3E7X9)
Pfam (PF01200)
In PDB		Saccharomyces cerevisiae (Baker's yeast)S33,Small ribosomal subunit protein eS28-A,YS27
77e, d940S ribosomal protein S29-Apolymer566675.72UniProt (P41057)
Pfam (PF00253)
In PDB		Saccharomyces cerevisiae (Baker's yeast)S36,Small ribosomal subunit protein uS14-A,YS29
78f, e040S ribosomal protein S30-Apolymer637137.52UniProt (P0CX33)
Pfam (PF04758)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Small ribosomal subunit protein eS30-A
79g, e1Ubiquitin-40S ribosomal protein S31polymer15217254.22UniProt (P05759)
Pfam (PF00240)
Pfam (PF01599)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
80h, RbGuanine nucleotide-binding protein subunit beta-like proteinpolymer31934841.22UniProt (P38011)
Pfam (PF00400)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Receptor for activated C kinase,Receptor of activated protein kinase C 1,RACK1,Small ribosomal subunit protein RACK1
81sR18S ribosomal RNApolymer1800579761.91GenBank (874346701)Saccharomyces cerevisiae
82AR, CS, A, 1, 3...osmium (III) hexamminenon-polymer286.41057Chemie (OHX)
831, CK, d3, DO, AR...MAGNESIUM IONnon-polymer24.31509Chemie (MG)
841, AR(3~{R})-3-[(1~{S})-2-[(1~{S},4~{a}~{R},6~{S},7~{S},8~{a}~{R})-6,7-bis(chloranyl)-5,5,8~{a}-trimethyl-2-methylidene-3,4,4~{a},6,7,8-hexahydro-1~{H}-naphthalen-1-yl]-1-oxidanyl-ethyl]pyrrolidine-2,5-dionenon-polymer402.42Chemie (G5B)
85DQ, AK, DR, d6, b...ZINC IONnon-polymer65.416Chemie (ZN)
86ARGLYCEROLnon-polymer92.12Chemie (GOL)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains159
Total formula weight6304765.5
Non-Polymers*Number of molecules2586
Total formula weight341399.5
All*Total formula weight6646165.0
*Water molecules are not included.

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PDB entries from 2024-04-24

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