4ZPK
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![BU of 4zpk by Molmil](/molmil-images/mine/4zpk) | Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with HRE DNA | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(*CP*AP*CP*GP*AP*CP*CP*CP*GP*CP*AP*CP*GP*TP*AP*CP*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ... | 著者 | Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. | 登録日 | 2015-05-08 | 公開日 | 2015-08-12 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structural integration in hypoxia-inducible factors. Nature, 524, 2015
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4ZP4
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![BU of 4zp4 by Molmil](/molmil-images/mine/4zp4) | Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | 著者 | Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. | 登録日 | 2015-05-07 | 公開日 | 2015-08-12 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.355 Å) | 主引用文献 | Structural integration in hypoxia-inducible factors. Nature, 524, 2015
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4ZPH
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![BU of 4zph by Molmil](/molmil-images/mine/4zph) | Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with Proflavine | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, PROFLAVIN | 著者 | Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. | 登録日 | 2015-05-07 | 公開日 | 2015-08-12 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural integration in hypoxia-inducible factors. Nature, 524, 2015
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6MGM
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![BU of 6mgm by Molmil](/molmil-images/mine/6mgm) | |
7SSA
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![BU of 7ssa by Molmil](/molmil-images/mine/7ssa) | |
3PXP
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![BU of 3pxp by Molmil](/molmil-images/mine/3pxp) | |
2UYZ
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![BU of 2uyz by Molmil](/molmil-images/mine/2uyz) | Non-covalent complex between Ubc9 and SUMO1 | 分子名称: | SMALL UBIQUITIN-RELATED MODIFIER 1, SODIUM ION, SUMO-CONJUGATING ENZYME UBC9 | 著者 | Knipscheer, P, van Dijk, W.J, Olsen, J.V, Mann, M, Sixma, T.K. | 登録日 | 2007-04-21 | 公開日 | 2007-06-12 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation. EMBO J., 26, 2007
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2VRR
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![BU of 2vrr by Molmil](/molmil-images/mine/2vrr) | Structure of SUMO modified Ubc9 | 分子名称: | FORMIC ACID, SMALL UBIQUITIN-RELATED MODIFIER 1, SODIUM ION, ... | 著者 | Knipscheer, P, Flotho, A, Klug, H, Olsen, J.V, van Dijk, W.J, Fish, A, Johnson, E.S, Mann, M, Sixma, T.K, Pichler, A. | 登録日 | 2008-04-13 | 公開日 | 2008-08-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Ubc9 sumoylation regulates SUMO target discrimination. Mol. Cell, 31, 2008
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7V7L
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![BU of 7v7l by Molmil](/molmil-images/mine/7v7l) | Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 3-alpha | 著者 | Diao, X, Ren, X, Li, F.W, Sun, X, Wu, D. | 登録日 | 2021-08-21 | 公開日 | 2022-05-18 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha. Nat Commun, 13, 2022
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4KFZ
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![BU of 4kfz by Molmil](/molmil-images/mine/4kfz) | Crystal structure of LMO2 and anti-LMO2 VH complex | 分子名称: | Anti-LMO2 VH, LMO-2, ZINC ION | 著者 | Sewell, H, Tanaka, T, El Omari, K, Cruz-Migoni, A, Mancini, E.J, Fuentes-Fernandez, N, Chambers, J, Rabbitts, T.H. | 登録日 | 2013-04-28 | 公開日 | 2014-01-22 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex. Sci Rep, 4, 2014
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5ZD4
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![BU of 5zd4 by Molmil](/molmil-images/mine/5zd4) | Crystal structure of MBP-fused BIL1/BZR1 in complex with double-stranded DNA | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*TP*TP*CP*AP*CP*AP*CP*GP*TP*GP*TP*GP*AP*AP*A)-3'), Maltose-binding periplasmic protein,Protein BRASSINAZOLE-RESISTANT 1, ... | 著者 | Nosaki, S, Miyakawa, T, Xu, Y, Nakamura, A, Hirabayashi, K, Tanokura, M. | 登録日 | 2018-02-22 | 公開日 | 2018-08-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Structural basis for brassinosteroid response by BIL1/BZR1. Nat Plants, 4, 2018
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6A5Q
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![BU of 6a5q by Molmil](/molmil-images/mine/6a5q) | |
7F2F
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![BU of 7f2f by Molmil](/molmil-images/mine/7f2f) | The complex of DNA with the C-terminal domain of TYE7 from Saccharomyces cerevisiae. | 分子名称: | DNA (5'-D(*CP*AP*GP*AP*TP*CP*AP*TP*GP*TP*GP*TP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*CP*AP*CP*AP*CP*AP*TP*GP*AP*TP*CP*T)-3'), Serine-rich protein TYE7 | 著者 | Gui, W. | 登録日 | 2021-06-10 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Crystal structure of the complex of DNA with the C-terminal domain of TYE7 from Saccharomyces cerevisiae. Acta Crystallogr.,Sect.F, 77, 2021
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8QMO
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![BU of 8qmo by Molmil](/molmil-images/mine/8qmo) | Cryo-EM structure of the benzo[a]pyrene-bound Hsp90-XAP2-AHR complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, Aryl hydrocarbon receptor, ... | 著者 | Kwong, H.S, Grandvuillemin, L, Sirounian, S, Ancelin, A, Lai-Kee-Him, J, Carivenc, C, Lancey, C, Ragan, T.J, Hesketh, E.L, Bourguet, W, Gruszczyk, J. | 登録日 | 2023-09-24 | 公開日 | 2024-01-10 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds. J.Mol.Biol., 436, 2024
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7VNI
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![BU of 7vni by Molmil](/molmil-images/mine/7vni) | AHR-ARNT PAS-B heterodimer | 分子名称: | Ahr homolog spineless, Aryl hydrocarbon receptor nuclear translocator, SULFATE ION | 著者 | Dai, S.Y. | 登録日 | 2021-10-11 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor. Nat Commun, 13, 2022
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7VNA
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![BU of 7vna by Molmil](/molmil-images/mine/7vna) | drosophlia AHR PAS-B domain | 分子名称: | Ahr homolog spineless | 著者 | Dai, S.Y. | 登録日 | 2021-10-10 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.597 Å) | 主引用文献 | Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor. Nat Commun, 13, 2022
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7VNH
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5I4V
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![BU of 5i4v by Molmil](/molmil-images/mine/5i4v) | Discovery of novel, orally efficacious Liver X Receptor (LXR) beta agonists | 分子名称: | Oxysterols receptor LXR-beta,Nuclear receptor coactivator 2, Retinoic acid receptor RXR-beta,Nuclear receptor coactivator 2, {2-[(2R)-4-[4-(hydroxymethyl)-3-(methylsulfonyl)phenyl]-2-(propan-2-yl)piperazin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanol | 著者 | Chen, G, McKeever, B.M. | 登録日 | 2016-02-12 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) beta Agonist. J.Med.Chem., 59, 2016
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6CZW
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![BU of 6czw by Molmil](/molmil-images/mine/6czw) | Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, {2-bromo-3-(3-chloro-5-fluorophenoxy)-6-[(difluoromethyl)sulfonyl]phenyl}methanol | 著者 | Du, X. | 登録日 | 2018-04-09 | 公開日 | 2018-10-31 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex To Be Published
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6D09
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![BU of 6d09 by Molmil](/molmil-images/mine/6d09) | Crystal structure of PT2440 bound to HIF2a-B*:ARNT-B* complex | 分子名称: | 3-{[(3R)-4-(difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-dioxo-2,3-dihydro-1H-1-benzothiophen-5-yl]oxy}-5-fluorobenzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | 著者 | Du, X. | 登録日 | 2018-04-10 | 公開日 | 2018-10-31 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex To Be Published
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6D0C
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![BU of 6d0c by Molmil](/molmil-images/mine/6d0c) | Crystal structure of HIF2a-B*:ARNT-B* complex | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | 著者 | Du, X. | 登録日 | 2018-04-10 | 公開日 | 2018-10-31 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex To Be Published
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6D0B
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![BU of 6d0b by Molmil](/molmil-images/mine/6d0b) | Crystal structure of PT1614 bound to HIF2a-B*:ARNT-B* complex | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, N-(3-chloro-5-fluorophenyl)-2-nitro-4-[(trifluoromethyl)sulfonyl]aniline | 著者 | Du, X. | 登録日 | 2018-04-10 | 公開日 | 2018-10-31 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structure of PT1614 bound to HIF2a-B*:ARNT-B* complex To Be Published
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4XT2
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![BU of 4xt2 by Molmil](/molmil-images/mine/4xt2) | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a tetrazole-containing antagonist | 分子名称: | (5S,7R)-5,7-bis(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | 著者 | Scheuermann, T.H, Gardner, K.H. | 登録日 | 2015-01-22 | 公開日 | 2015-12-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.698 Å) | 主引用文献 | Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2. J.Med.Chem., 58, 2015
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6X28
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![BU of 6x28 by Molmil](/molmil-images/mine/6x28) | Crystal structure of PT2243 bound to HIF2a-B*:ARNT-B* complex | 分子名称: | (1R)-4-(3,5-difluorophenoxy)-7-(trifluoromethyl)-2,3-dihydro-1H-inden-1-ol, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | 著者 | Du, X. | 登録日 | 2020-05-20 | 公開日 | 2021-05-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Crystal structure of PT2243 bound to HIF2-PasB*:ARNT-PasB* complex To Be Published
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6X37
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![BU of 6x37 by Molmil](/molmil-images/mine/6x37) | Crystal structure of PT3245 bound to HIF2a-B*:ARNT-B* complex | 分子名称: | 3-fluoro-5-{[(7R)-7-hydroxy-1-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-4-yl]oxy}benzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | 著者 | Du, X. | 登録日 | 2020-05-21 | 公開日 | 2021-05-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Crystal structure of PT3245 bound to HIF2a-B*:ARNT-B* complex To Be Published
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