7JN7
| Human DPP9-CARD8 complex | 分子名称: | Caspase recruitment domain-containing protein 8, Dipeptidyl peptidase 9, [(2~{R})-1-[(2~{R})-2-azanyl-3-methyl-butanoyl]pyrrolidin-2-yl]boronic acid | 著者 | Sharif, H, Hollingsworth, L.R. | 登録日 | 2020-08-04 | 公開日 | 2021-05-19 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment. Immunity, 54, 2021
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7JKQ
| Human DPP9-CARD8 complex | 分子名称: | Caspase recruitment domain-containing protein 8, Dipeptidyl peptidase 9 | 著者 | Sharif, H, Hollingsworth, L.R. | 登録日 | 2020-07-28 | 公開日 | 2021-05-26 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment. Immunity, 54, 2021
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5WVE
| Apaf-1-Caspase-9 holoenzyme | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Apoptotic protease-activating factor 1, Caspase, ... | 著者 | Li, Y, Zhou, M, Hu, Q, Shi, Y. | 登録日 | 2016-12-24 | 公開日 | 2017-02-08 | 最終更新日 | 2017-03-01 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2A5Y
| Structure of a CED-4/CED-9 complex | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Apoptosis regulator ced-9, MAGNESIUM ION, ... | 著者 | Yan, N, Liu, Q, Hao, Q, Gu, L, Shi, Y. | 登録日 | 2005-07-01 | 公開日 | 2005-10-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Nature, 437, 2005
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3SFZ
| Crystal structure of full-length murine Apaf-1 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Apoptotic peptidase activating factor 1, GAMMA-BUTYROLACTONE | 著者 | Eschenburg, S, Reubold, T.F. | 登録日 | 2011-06-14 | 公開日 | 2011-08-24 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis. Structure, 19, 2011
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3SHF
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7CRW
| Cryo-EM structure of rNLRP1-rDPP9 complex | 分子名称: | Dipeptidyl peptidase 9, NLR family protein 1 | 著者 | Huang, M.H, Zhang, X.X, Wang, J, Chai, J.J. | 登録日 | 2020-08-14 | 公開日 | 2021-03-24 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | 主引用文献 | Structural and biochemical mechanisms of NLRP1 inhibition by DPP9. Nature, 592, 2021
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6X6A
| Cryo-EM structure of NLRP1-DPP9 complex | 分子名称: | Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1 | 著者 | Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H. | 登録日 | 2020-05-27 | 公開日 | 2021-03-10 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Nature, 592, 2021
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6X6C
| Cryo-EM structure of NLRP1-DPP9-VbP complex | 分子名称: | Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1, ... | 著者 | Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H. | 登録日 | 2020-05-27 | 公開日 | 2021-03-10 | 最終更新日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Nature, 592, 2021
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7DNJ
| K63-polyUb MDA5CARDs complex | 分子名称: | Interferon-induced helicase C domain-containing protein 1, Ubiquitin | 著者 | Song, B, Chen, Y, Luo, D.H, Zheng, J. | 登録日 | 2020-12-09 | 公開日 | 2021-10-13 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains. Immunity, 54, 2021
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7DNI
| MDA5 CARDs-MAVS CARD polyUb complex | 分子名称: | Interferon-induced helicase C domain-containing protein 1, Mitochondrial antiviral-signaling protein, Ubiquitin | 著者 | Song, B, Chen, Y, Luo, D.H, Zheng, J. | 登録日 | 2020-12-09 | 公開日 | 2021-10-13 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains. Immunity, 54, 2021
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7NIC
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7NGA
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7NIQ
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7BKP
| CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ... | 著者 | Singh, R, Herrero del Valle, A, Yu, Q, Modis, Y. | 登録日 | 2021-01-16 | 公開日 | 2021-11-17 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA. Nat Commun, 12, 2021
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2N83
| p75NTR DD:RIP2 CARD | 分子名称: | Receptor-interacting serine/threonine-protein kinase 2, Tumor necrosis factor receptor superfamily member 16 | 著者 | Lin, Z, Ibanez, C.F. | 登録日 | 2015-10-02 | 公開日 | 2015-12-23 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural basis of death domain signaling in the p75 neurotrophin receptor Elife, 4, 2015
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3JBT
| Atomic structure of the Apaf-1 apoptosome | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Apoptotic protease-activating factor 1, Cytochrome c, ... | 著者 | Zhou, M, Li, Y, Hu, Q, Bai, X, Huang, W, Yan, C, Scheres, S.H.W, Shi, Y. | 登録日 | 2015-10-15 | 公開日 | 2015-11-18 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1 Genes Dev., 29, 2015
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3J2T
| An improved model of the human apoptosome | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Apoptotic protease-activating factor 1, Cytochrome c, ... | 著者 | Yuan, S, Topf, M, Akey, C.W. | 登録日 | 2012-12-23 | 公開日 | 2013-04-10 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (9.5 Å) | 主引用文献 | Changes in apaf-1 conformation that drive apoptosome assembly. Biochemistry, 52, 2013
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4JQW
| Crystal Structure of a Complex of NOD1 CARD and Ubiquitin | 分子名称: | Nucleotide-binding oligomerization domain-containing protein 1, PHOSPHATE ION, Polyubiquitin-C | 著者 | Ver Heul, A.M, Gakhar, L, Piper, R.C, Ramaswamy, S. | 登録日 | 2013-03-20 | 公開日 | 2014-03-26 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structure of a complex of NOD1 CARD and ubiquitin Plos One, 9, 2014
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6H66
| CryoEM structure of the MDA5-dsRNA filament with 93 degree twist and without nucleotide | 分子名称: | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), ... | 著者 | Yu, Q, Qu, K, Modis, Y. | 登録日 | 2018-07-26 | 公開日 | 2018-11-21 | 最終更新日 | 2020-11-18 | 実験手法 | ELECTRON MICROSCOPY (4.16 Å) | 主引用文献 | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6H61
| CryoEM structure of the MDA5-dsRNA filament with 89 degree twist and without nucleotide | 分子名称: | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), ... | 著者 | Yu, Q, Qu, K, Modis, Y. | 登録日 | 2018-07-25 | 公開日 | 2018-11-21 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.02 Å) | 主引用文献 | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6GKM
| CryoEM structure of the MDA5-dsRNA filament in complex with ATP (10 mM) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3'), ... | 著者 | Yu, Q, Qu, K, Modis, Y. | 登録日 | 2018-05-21 | 公開日 | 2018-11-21 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6GJZ
| CryoEM structure of the MDA5-dsRNA filament in complex with AMPPNP | 分子名称: | Interferon-induced helicase C domain-containing protein 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3'), ... | 著者 | Yu, Q, Qu, K, Modis, Y. | 登録日 | 2018-05-17 | 公開日 | 2018-11-21 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.06 Å) | 主引用文献 | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6GKH
| CryoEM structure of the MDA5-dsRNA filament in complex with ADP-AlF4 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ... | 著者 | Yu, Q, Qu, K, Modis, Y. | 登録日 | 2018-05-21 | 公開日 | 2018-11-21 | 最終更新日 | 2020-11-18 | 実験手法 | ELECTRON MICROSCOPY (4.06 Å) | 主引用文献 | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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