PDB: 35463 件ウェブページステータス検索Chemie searchBIRD

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4TUM	Crystal structure of Ankyrin Repeat Domain of AKR2 分子名称: Ankyrin repeat domain-containing protein 2 著者 Gwon, G.H, Cho, Y. 登録日 2014-06-24 公開日 2014-09-24 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 An Ankyrin Repeat Domain of AKR2 Drives Chloroplast Targeting through Coincident Binding of Two Chloroplast Lipids. Dev.Cell, 30, 2014
4U8Y	Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB 分子名称: (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, DARPin, DODECYL-BETA-D-MALTOSIDE, ... 著者 Pos, K.M. 登録日 2014-08-05 公開日 2014-10-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.099 Å) 主引用文献 Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB. Elife, 3, 2014
7S0F	Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric Gi protein 分子名称: Beta1-Adrenergic Receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Paknejad, N, Alegre, K.O, Su, M, Lou, J.S, Huang, J, Jordan, K.D, Eng, E.T, Meyerson, J.R, Hite, R.K, Huang, X.Y. 登録日 2021-08-30 公開日 2021-11-17 最終更新日 2021-12-01 実験手法 ELECTRON MICROSCOPY (2.96 Å) 主引用文献 Structural basis and mechanism of activation of two different families of G proteins by the same GPCR. Nat.Struct.Mol.Biol., 28, 2021
7S0G	Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric Gi/s chimera protein 分子名称: Beta1-Adrenergic Receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Paknejad, N, Alegre, K.O, Su, M, Lou, J.S, Huang, J, Jordan, K.D, Eng, E.T, Meyerson, J.R, Hite, R.K, Huang, X.Y. 登録日 2021-08-30 公開日 2021-11-17 最終更新日 2021-12-01 実験手法 ELECTRON MICROSCOPY (3.86 Å) 主引用文献 Structural basis and mechanism of activation of two different families of G proteins by the same GPCR. Nat.Struct.Mol.Biol., 28, 2021
4UI6	Crystal structure of human tankyrase 2 in complex with TA-47 分子名称: 8-METHOXY-2-[4-(TRIFLUOROMETHYL)PHENYL]-3,4-DIHYDROQUINAZOLIN-4-ONE, GLYCEROL, SULFATE ION, ... 著者 Haikarainen, T, Lehtio, L. 登録日 2015-03-27 公開日 2016-04-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases. Eur.J.Med.Chem., 118, 2016
4UI3	Crystal structure of human tankyrase 2 in complex with TA-26 分子名称: 2-[4-(trifluoromethyl)phenyl]-3H-quinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Haikarainen, T, Lehtio, L. 登録日 2015-03-27 公開日 2016-04-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases. Eur.J.Med.Chem., 118, 2016
4UHG	Crystal structure of human tankyrase 2 in complex with TA-21 分子名称: 2-(4-METHYLPHENYL)-3,4-DIHYDROQUINAZOLIN-4-ONE, GLYCEROL, SULFATE ION, ... 著者 Haikarainen, T, Lehtio, L. 登録日 2015-03-24 公開日 2016-04-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases. Eur.J.Med.Chem., 118, 2016
4UI5	Crystal structure of human tankyrase 2 in complex with TA-41 分子名称: 8-methoxy-2-(4-methylphenyl)-3,4-dihydroquinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Haikarainen, T, Lehtio, L. 登録日 2015-03-27 公開日 2016-04-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases. Eur.J.Med.Chem., 118, 2016
4U2N	Crystal structure of a complex of the Miz1- and Nac1 POZ domains. 分子名称: Zinc finger and BTB domain-containing protein 17,Nucleus accumbens-associated protein 1 著者 Stead, M.A, Wright, S.C. 登録日 2014-07-17 公開日 2014-12-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structures of heterodimeric POZ domains of Miz1/BCL6 and Miz1/NAC1. Acta Crystallogr.,Sect.F, 70, 2014
4U3J	TOG2:alpha/beta-tubulin complex 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Protein STU2, ... 著者 Ayaz, P, Rice, L.M. 登録日 2014-07-22 公開日 2014-08-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 A tethered delivery mechanism explains the catalytic action of a microtubule polymerase. Elife, 3, 2014
4U3Z	APO MAP4K4 T181E Phosphomimetic Mutant 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mitogen-activated protein kinase kinase kinase kinase 4, SODIUM ION 著者 Harris, S.F, Wu, P, Coons, M. 登録日 2014-07-23 公開日 2016-01-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Structural Plasticity and Kinase Activation in a Cohort of MAP4K4 Structures to be published
4U43	MAP4K4 in complex with inhibitor (compound 6) 分子名称: Mitogen-activated protein kinase kinase kinase kinase 4, N-(pyridin-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine 著者 Harris, S.F, Wu, P, Coons, M. 登録日 2014-07-23 公開日 2014-09-03 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors. Bioorg.Med.Chem.Lett., 24, 2014
4U40	Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) Bound to AMPPNP 分子名称: MAGNESIUM ION, Mitogen-activated protein kinase kinase kinase kinase 4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Harris, S.F, Wu, P, Coons, M. 登録日 2014-07-23 公開日 2016-01-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Plasticity and Kinase Activation in a Cohort of MAP4K4 Structures to be published
4U42	MAP4K4 T181E Mutant Bound to inhibitor compound 1 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-[(3S)-3-(4-methyl-1H-pyrazol-3-yl)piperidin-1-yl]pyrido[3,2-d]pyrimidin-4-amine, MAGNESIUM ION, ... 著者 Harris, S.F, Wu, P, Coons, M. 登録日 2014-07-23 公開日 2016-01-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.504 Å) 主引用文献 Structural Plasticity and Kinase Activation in a Cohort of MAP4K4 Structures to be published
4U4C	The molecular architecture of the TRAMP complex reveals the organization and interplay of its two catalytic activities 分子名称: 1,2-ETHANEDIOL, ATP-dependent RNA helicase DOB1, CHLORIDE ION, ... 著者 Falk, S, Weir, J.R, Hentschel, J, Reichelt, P, Bonneau, F, Conti, E. 登録日 2014-07-23 公開日 2014-09-24 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The Molecular Architecture of the TRAMP Complex Reveals the Organization and Interplay of Its Two Catalytic Activities. Mol.Cell, 55, 2014
4U2M	Crystal structure of a complex of the Miz1- and BCL6 POZ domains. 分子名称: Zinc finger and BTB domain-containing protein 17,B-cell lymphoma 6 protein 著者 Stead, M.A, Wright, S.C. 登録日 2014-07-17 公開日 2014-12-10 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Structures of heterodimeric POZ domains of Miz1/BCL6 and Miz1/NAC1. Acta Crystallogr.,Sect.F, 70, 2014
4U6A	X-ray crystal structure of human TNKS in complex with a small molecule inhibitor 分子名称: 1,2-ETHANEDIOL, 3-(4-{[4-(dimethylamino)piperidin-1-yl]methyl}phenyl)-5-methylisoquinolin-1(2H)-one, GLYCEROL, ... 著者 Oliver, A.W. 登録日 2014-07-28 公開日 2015-07-08 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Design and discovery of 3-aryl-5-substituted-isoquinolin-1- ones as potent and selective tankyrase inhibitors To be published
6S6D	Crystal structure of RagA-Q66L-GTP/RagC-S75N-GDP GTPase heterodimer complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Anandapadamanaban, M, Masson, G.R, Perisic, O, Kaufman, J, Williams, R.L. 登録日 2019-07-02 公開日 2019-10-16 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
4UVN	Crystal structure of human tankyrase 2 in complex with 5-amino-3-(4- chlorophenyl)-1,2-dihydroisoquinolin-1-one 分子名称: 5-amino-3-(4-chlorophenyl)isoquinolin-1(2H)-one, GLYCEROL, SULFATE ION, ... 著者 Narwal, M, Haikarainen, T, Lehtio, L. 登録日 2014-08-07 公開日 2015-07-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Exploration of the Nicotinamide-Binding Site of the Tankyrases, Identifying 3-Arylisoquinolin-1-Ones as Potent and Selective Inhibitors in Vitro. Bioorg.Med.Chem., 23, 2015
4UUH	X-ray crystal structure of human TNKS in complex with a small molecule inhibitor 分子名称: 1,2-ETHANEDIOL, 5-methyl-3-[4-(piperazin-1-ylmethyl)phenyl]isoquinolin-1(2H)-one, GLYCEROL, ... 著者 Oliver, A.W, Rajasekaran, M.B, Pearl, L.H. 登録日 2014-07-28 公開日 2015-07-08 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1- Ones as Potent and Selective Tankyrase Inhibitors Medchemcommm, 6, 2015
6S6A	Crystal structure of RagA-Q66L/RagC-T90N GTPase heterodimer complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Anandapadamanaban, M, Masson, G.R, Perisic, O, Kaufman, J, Williams, R.L. 登録日 2019-07-02 公開日 2019-10-16 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
6QYX	p38(alpha) MAP kinase with the activation loop of ERK2 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Mitogen-activated protein kinase 14,Mitogen-activated protein kinase 1,Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Livnah, O, Eitan-Wexler, M, Vinograd, N. 登録日 2019-03-10 公開日 2020-04-01 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 The bacterial metalloprotease NleD selectively cleaves mitogen-activated protein kinases that have high flexibility in their activation loop. J.Biol.Chem., 295, 2020
3BMY	Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90 分子名称: 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol, Heat shock protein HSP 90-alpha 著者 Gopalsamy, A, Shi, M, Vogan, E.M, Golas, J, Jacob, J, Johnson, J, Lee, F, Nilakantan, R, Peterson, R, Svenson, K, Tam, M.S, Wen, Y, Chopra, R, Ellingboe, J, Arndt, K, Boschelli, F. 登録日 2007-12-13 公開日 2008-07-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90. J.Med.Chem., 51, 2008
3BND	Lipoxygenase-1 (Soybean), I553V Mutant 分子名称: FE (III) ION, Seed lipoxygenase-1 著者 Tomchick, D.R. 登録日 2007-12-14 公開日 2008-04-01 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Enzyme structure and dynamics affect hydrogen tunneling: the impact of a remote side chain (I553) in soybean lipoxygenase-1. Proc.Natl.Acad.Sci.Usa, 105, 2008
3K2R	Crystal Structure of Spin Labeled T4 Lysozyme Mutant K65V1/R76V1 分子名称: CHLORIDE ION, HEXANE-1,6-DIOL, Lysozyme, ... 著者 Toledo Warshaviak, D, Cascio, D, Khramtsov, V.V, Hubbell, W.L. 登録日 2009-09-30 公開日 2010-10-13 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal Structure of Spin Labeled T4 Lysozyme Mutant K65V1/R76V1 To be Published

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