4U43

MAP4K4 in complex with inhibitor (compound 6)

Summary for 4U43

• Entry DOI: 10.2210/pdb4u43/pdb
• Related: 4U3Y 4U3Z 4U40 4U41 4U42 4U44 4U45
• Descriptor: Mitogen-activated protein kinase kinase kinase kinase 4, N-(pyridin-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (3 entities in total)
• Functional Keywords: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : O95819
• Total number of polymer chains: 2
• Total formula weight: 75951.38

Authors

Harris, S.F.,Wu, P.,Coons, M. (deposition date: 2014-07-23, release date: 2014-09-03, Last modification date: 2023-12-27)

• Primary citation: Wang, L.,Stanley, M.,Boggs, J.W.,Crawford, T.D.,Bravo, B.J.,Giannetti, A.M.,Harris, S.F.,Magnuson, S.R.,Nonomiya, J.,Schmidt, S.,Wu, P.,Ye, W.,Gould, S.E.,Murray, L.J.,Ndubaku, C.O.,Chen, H.; Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.; Bioorg.Med.Chem.Lett., 24:4546-4552, 2014; PubMed: 25139565; DOI: 10.1016/j.bmcl.2014.07.071

Experimental method

X-RAY DIFFRACTION (2.18 Å)